INT81089

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 4.42
Pain Relevance 3.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
intestine 2
sensory neurons 1
plasma 1
central nervous system 1
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 109 100.00 Very High Very High Very High
addiction 3 99.92 Very High Very High Very High
Inflammation 10 99.84 Very High Very High Very High
Central nervous system 7 99.68 Very High Very High Very High
imagery 15 99.22 Very High Very High Very High
tissue acidosis 7 98.84 Very High Very High Very High
Action potential 1 98.32 Very High Very High Very High
Pain 19 98.18 Very High Very High Very High
Glutamate 4 97.84 Very High Very High Very High
Hippocampus 4 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.84 Very High Very High Very High
Acidosis 29 99.12 Very High Very High Very High
Death 40 98.28 Very High Very High Very High
Pain 16 98.18 Very High Very High Very High
Injury 6 97.96 Very High Very High Very High
Hyperalgesia 1 92.04 High High
Status Epilepticus 3 89.44 High High
Epilepsy 1 75.00 Quite High
Ganglion Cysts 1 72.76 Quite High
Toxicity 24 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, although our whole-field imaging data agree with previous studies that activation of ASIC1a receptors can potentially cause elevations in intracellular free Ca(2+), our single cell data strongly challenges the view that Ca(2+) entry through the ASIC1a receptor itself contributes to this response.
Positive_regulation (activation) of ASIC1a associated with imagery
1) Confidence 0.65 Published 2009 Journal Cell Calcium Section Abstract Doc Link 19185346 Disease Relevance 0.07 Pain Relevance 0.18
Instead, it increases the acidotoxicity mediated by ASIC1a by increasing the level of ASIC1a at cell surface.
Positive_regulation (increasing) of ASIC1a
2) Confidence 0.57 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.45 Pain Relevance 0
This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e.
Positive_regulation (activation) of ASIC1a
3) Confidence 0.49 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.18 Pain Relevance 0.27
This paper shows that Zn(2+) potentiates the acid activation of homomeric and heteromeric ASIC2a-containing channels (i.e.
Positive_regulation (activation) of ASIC1a
4) Confidence 0.49 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.18 Pain Relevance 0.27
Zn(2+) shifts the pH dependence of activation of the ASIC1a+2a current from a pH(0.5) of 5.5 to 6.0.
Positive_regulation (activation) of ASIC1a associated with addiction
5) Confidence 0.45 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11457851 Disease Relevance 0.16 Pain Relevance 0.25
RESULTS: In the Western blot, there was a significant three-fold increase in the mean relative optical density of the ASIC-3 55-kDa band (but not ASIC-1 or ASIC-2) in full-thickness inflamed intestine, as well as in separated muscle and mucosal layers.
Positive_regulation (increase) of ASIC in intestine
6) Confidence 0.44 Published 2001 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11507351 Disease Relevance 0.17 Pain Relevance 0
RESULTS: In the Western blot, there was a significant three-fold increase in the mean relative optical density of the ASIC-3 55-kDa band (but not ASIC-1 or ASIC-2) in full-thickness inflamed intestine, as well as in separated muscle and mucosal layers.
Positive_regulation (increase) of ASIC-2 in intestine
7) Confidence 0.44 Published 2001 Journal Eur J Gastroenterol Hepatol Section Body Doc Link 11507351 Disease Relevance 0.17 Pain Relevance 0
Detection of a shorter fragment of ASIC1a (461 bp) with primers HASIC3 and HASIC4, also yielded negative results even after 50 cycles (Figure 1, Lane C).
Positive_regulation (fragment) of ASIC1a
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0 Pain Relevance 0.06
ASIC activation substantially depolarized OLC plasma membrane in current clamp studies, and elicited transient elevations in intracellular Ca2+ in imaging studies.
Positive_regulation (activation) of ASIC in plasma associated with imagery and asic
9) Confidence 0.40 Published 2008 Journal Glia Section Abstract Doc Link 18452213 Disease Relevance 0.05 Pain Relevance 0.37
Unlike the wild-type PICK1, PICK1 2K-E did not increase surface levels of ASIC1a (surface/total ASIC1a ratio: ASIC1a alone: 5.05% ± 0.9%; ASIC1a + PICK1: 7.80% ± 1.4%; ASIC1a + PICK1 2K-E: 5.18% ± 1.6%, n = 5, Figure 1C).
Neg (not) Positive_regulation (increase) of ASIC1a
10) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.05
When the BAR domain of PICK1 was mutated, it can no longer induce ASIC1a clustering or change its surface levels, although the interaction between the two proteins was unaffected.
Positive_regulation (induce) of ASIC1a
11) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.42 Pain Relevance 0.10
Co-expressing with PICK1 increased ASIC1a surface/total ratio to 7.80% ± 1.4% (n = 5, p < 0.01, paired t-test).
Positive_regulation (increased) of ASIC1a
12) Confidence 0.33 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
Sodium nitroprusside, a potent NO donor not only increases the ASIC mediated currents but also increases cell death at low pH.
Positive_regulation (increases) of ASIC associated with death and asic
13) Confidence 0.25 Published 2010 Journal Nitric Oxide Section Abstract Doc Link 20045740 Disease Relevance 1.05 Pain Relevance 0.69
A splice variant of ASIC2, ASIC2b, is not active on its own but modifies the properties of ASIC3.
Neg (not) Positive_regulation (active) of ASIC2b
14) Confidence 0.10 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10187795 Disease Relevance 0.20 Pain Relevance 0.24
Furthermore, we show that GMQ activates sensory neurons and causes pain-related behaviors in an ASIC3-dependent manner, indicating the functional significance of ASIC activation by nonproton ligands.
Positive_regulation (activation) of ASIC in sensory neurons associated with pain and asic
15) Confidence 0.09 Published 2010 Journal Neuron Section Abstract Doc Link 20920791 Disease Relevance 0.17 Pain Relevance 0.31
We had previously shown that ASIC transcript levels were increased in inflammatory conditions in vivo.
Positive_regulation (increased) of ASIC associated with inflammation and asic
16) Confidence 0.05 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12486159 Disease Relevance 0.46 Pain Relevance 0.79
ASIC1a, ASIC2a, and ASIC2b are also distributed in the central nervous system where their function remains unclear.
Positive_regulation (distributed) of ASIC2b in central nervous system associated with central nervous system
17) Confidence 0.00 Published 2001 Journal Neurobiol. Dis. Section Abstract Doc Link 11162239 Disease Relevance 0.67 Pain Relevance 0.24

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