INT8112

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Context Info
Confidence 0.58
First Reported 1982
Last Reported 2010
Negated 5
Speculated 8
Reported most in Body
Documents 38
Total Number 45
Disease Relevance 22.04
Pain Relevance 2.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
liver 1
spinal cord neurons 1
red blood cell 1
kidney 1
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 11 100.00 Very High Very High Very High
anesthesia 22 99.92 Very High Very High Very High
Angina 26 99.80 Very High Very High Very High
cytokine 28 99.16 Very High Very High Very High
Pain 18 94.72 High High
c fibre 1 89.84 High High
tolerance 3 89.80 High High
unmyelinated 1 89.48 High High
medulla 70 86.96 High High
Analgesic 1 86.44 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 60 99.80 Very High Very High Very High
Erythrocytosis 17 99.80 Very High Very High Very High
Chronic Renal Failure 71 99.76 Very High Very High Very High
Renal Failure 46 99.52 Very High Very High Very High
Myelodysplastic Syndromes 89 99.48 Very High Very High Very High
Renal Disease 41 99.40 Very High Very High Very High
Anaemia 600 99.32 Very High Very High Very High
Cancer 224 99.24 Very High Very High Very High
Apoptosis 76 99.24 Very High Very High Very High
Cognitive Disorder 29 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
From a clinical point this probably means that erythropoietin is not the sole factor responsible for erythrocytosis in those patients, as was the case in this patient.
Neg (not) Regulation (responsible) of erythropoietin associated with erythrocytosis
1) Confidence 0.58 Published 2006 Journal BMC Urol Section Body Doc Link PMC1590043 Disease Relevance 1.72 Pain Relevance 0.06
To examine the effects of recombinant human erythropoietin (rHuEPO) on hospital utilization, hospital costs, and Medicare reimbursements for hospital care, a longitudinal, matched cohort study was conducted using Medicare claims data of 23,806 Medicare-eligible, dialysis patients who received rHuEPO, did not have a transplant, and were alive for 18 mo or longer and 22,720 controls matched on age, sex, race, cause of ESRD, and dialysis modality.
Spec (examine) Regulation (effects) of erythropoietin associated with chronic renal failure
2) Confidence 0.45 Published 1994 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 8161727 Disease Relevance 0.09 Pain Relevance 0
Effect of recombinant erythropoietin on hospital admissions, readmissions, length of stay, and costs of dialysis patients.
Regulation (Effect) of erythropoietin
3) Confidence 0.45 Published 1994 Journal J. Am. Soc. Nephrol. Section Title Doc Link 8161727 Disease Relevance 0.30 Pain Relevance 0.05
To examine the effects of recombinant human erythropoietin (rHuEPO) on hospital utilization, hospital costs, and Medicare reimbursements for hospital care, a longitudinal, matched cohort study was conducted using Medicare claims data of 23,806 Medicare-eligible, dialysis patients who received rHuEPO, did not have a transplant, and were alive for 18 mo or longer and 22,720 controls matched on age, sex, race, cause of ESRD, and dialysis modality.
Spec (examine) Regulation (effects) of rHuEPO associated with chronic renal failure
4) Confidence 0.45 Published 1994 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 8161727 Disease Relevance 0.09 Pain Relevance 0
[Effect of recombinant human erythropoietin (rEPO) on angina pectoris in patients with chronic maintenance hemodialysis].
Regulation ([Effect) of rEPO associated with angina
5) Confidence 0.45 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Title Doc Link 1875559 Disease Relevance 0.32 Pain Relevance 0.27
[Effect of recombinant human erythropoietin (rEPO) on angina pectoris in patients with chronic maintenance hemodialysis].
Regulation ([Effect) of erythropoietin associated with angina
6) Confidence 0.45 Published 1991 Journal Nippon Jinzo Gakkai Shi Section Title Doc Link 1875559 Disease Relevance 0.32 Pain Relevance 0.27
fMRI is performed before and after treatment to investigate the neurophysiological underpinnings for effects of repeated Epo administration on cognitive function and mood.
Spec (investigate) Regulation (effects) of Epo associated with cognitive disorder
7) Confidence 0.45 Published 2010 Journal Trials Section Body Doc Link PMC2967509 Disease Relevance 0.29 Pain Relevance 0
A preliminary evaluation of the effects of recombinant human erythropoietin (rHuEPO) was carried out in 14 patients with SSc with nonhealing, severe cutaneous ulcers.
Regulation (effects) of erythropoietin associated with ulcers and systemic sclerosis
8) Confidence 0.45 Published 2007 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 17397351 Disease Relevance 0.81 Pain Relevance 0.05
A preliminary evaluation of the effects of recombinant human erythropoietin (rHuEPO) was carried out in 14 patients with SSc with nonhealing, severe cutaneous ulcers.
Regulation (effects) of rHuEPO associated with ulcers and systemic sclerosis
9) Confidence 0.45 Published 2007 Journal Clin. Exp. Dermatol. Section Abstract Doc Link 17397351 Disease Relevance 0.82 Pain Relevance 0.05
Erythropoietin is a glycoprotein which controls red blood cell production.
Regulation (controls) of Erythropoietin in red blood cell
10) Confidence 0.45 Published 1991 Journal Leukemia Section Abstract Doc Link 1961041 Disease Relevance 0.52 Pain Relevance 0
However, in this case investigators preferred to do it in the target patients since their renal failure condition would have considerable influence on EPO pharmacokinetics and pharmacodynamics.
Regulation (influence) of EPO associated with renal failure
11) Confidence 0.45 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1164417 Disease Relevance 0.31 Pain Relevance 0
However, younger age (<50 years) in women tended to influence Hb towards lower levels and, as a possible physician's response, towards higher EPO doses.
Spec (possible) Regulation (influence) of EPO
12) Confidence 0.45 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 0.60 Pain Relevance 0
We also assessed the influence of EPO dose on mortality and found a trend for a lower mortality in patients with Hb>11 g/dL and EPO dose <200 IU/kg/week, compared to the same Hb level but EPO dose ?
Regulation (influence) of EPO
13) Confidence 0.45 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2621153 Disease Relevance 0.75 Pain Relevance 0
The effects of erythropoietin on pain and spinal cord neurons have not been examined.
Regulation (effects) of erythropoietin in spinal cord neurons
14) Confidence 0.45 Published 2003 Journal Spine Section Body Doc Link 14652474 Disease Relevance 0.20 Pain Relevance 0
The aim of this study was to investigate the effects of recombinant human erythropoietin (rh-EPO) in patients with cancer-related anaemia.
Spec (investigate) Regulation (effects) of erythropoietin associated with anaemia and cancer
15) Confidence 0.45 Published 1994 Journal Oncology Section Abstract Doc Link 7970493 Disease Relevance 0.94 Pain Relevance 0.05
The effect of chronic treatment with recombinant human erythropoietin (rHuEPO) on GH secretion in uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD) is not known.
Regulation (effect) of erythropoietin associated with renal failure and uremia
16) Confidence 0.44 Published 1992 Journal Adv Perit Dial Section Abstract Doc Link 1361819 Disease Relevance 0.61 Pain Relevance 0.06
The effect of chronic treatment with recombinant human erythropoietin (rHuEPO) on GH secretion in uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD) is not known.
Regulation (effect) of rHuEPO associated with renal failure and uremia
17) Confidence 0.44 Published 1992 Journal Adv Perit Dial Section Abstract Doc Link 1361819 Disease Relevance 0.61 Pain Relevance 0.06
Small studies have shown that monthly administration of darbepoetin was effective in the treatment of anemia in dialysis and non-dialysis patients with CKD (Jadoul et al 2004; Ling et al 2005; Theodoridis et al 2005).
Regulation (effective) of epoetin associated with chronic renal failure and anaemia
18) Confidence 0.44 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673829 Disease Relevance 0.50 Pain Relevance 0
In the majority of patients, regular intravenous erythropoietin treatment was underway.
Regulation (regular) of erythropoietin
19) Confidence 0.44 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC2903573 Disease Relevance 0.05 Pain Relevance 0.08
Whether the regulation of HSP70 and caspase 3 is a consequence of Epo signalling or secondary to other preconditioning responses is unknown.
Spec (Whether) Regulation (consequence) of Epo
20) Confidence 0.41 Published 2009 Journal Malar J Section Body Doc Link PMC2785829 Disease Relevance 0.68 Pain Relevance 0.07

General Comments

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