INT81153

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 33
Disease Relevance 6.04
Pain Relevance 8.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 4
lateral 3
MnPO 2
spinal 2
hypothalamus 2
Hcrt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 3 100.00 Very High Very High Very High
Neuropeptide 50 99.92 Very High Very High Very High
Analgesic 4 99.84 Very High Very High Very High
Spinal cord 20 99.82 Very High Very High Very High
Intracerebroventricular 5 99.72 Very High Very High Very High
dorsal root ganglion 4 99.68 Very High Very High Very High
GABAergic 14 99.24 Very High Very High Very High
intrathecal 15 99.16 Very High Very High Very High
spinal dorsal horn 6 98.60 Very High Very High Very High
antagonist 40 98.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.32 Very High Very High Very High
Ganglion Cysts 4 99.20 Very High Very High Very High
Stress 42 98.80 Very High Very High Very High
African Trypanosomiasis 26 98.68 Very High Very High Very High
Inflammatory Pain 2 97.84 Very High Very High Very High
Depression 11 97.16 Very High Very High Very High
Neuropathic Pain 16 97.00 Very High Very High Very High
Anxiety Disorder 13 96.52 Very High Very High Very High
Nociception 4 95.20 Very High Very High Very High
Pain 11 92.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypocretin (orexin) is synthesized by neurons in the lateral hypothalamus and has been reported to increase food intake and regulate the neuroendocrine system.
Gene_expression (synthesized) of Hypocretin in lateral
1) Confidence 0.77 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10191330 Disease Relevance 0.12 Pain Relevance 0.21
Digital-imaging physiological studies with fura-2 detected a rise in intracellular calcium in response to hypocretin in cultured rat spinal cord neurons, indicating that spinal cord neurons express hypocretin-responsive receptors.
Gene_expression (express) of hypocretin in spinal cord neurons associated with imagery and spinal cord
2) Confidence 0.77 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10191330 Disease Relevance 0.14 Pain Relevance 0.51
overlaps with the region of cells expressing melanin-concentrating hormone (MCH) and hypocretin/orexin [28].
Gene_expression (expressing) of hypocretin
3) Confidence 0.75 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.13 Pain Relevance 0.06
The lateral hypothalamic region containing cells expressing MCH and hypocretin/orexin appears
Gene_expression (expressing) of hypocretin in lateral
4) Confidence 0.75 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0.04
Glucose-sensitive neurons in the lateral hypothalamic area produce orexin-A (OxA) as well as orexin-B (OxB) and send their axons to the spinal dorsal horn, which predominantly expresses orexin receptor-1 (OX-1), showing a higher sensitivity to OxA.
Gene_expression (produce) of orexin-A in spinal associated with spinal dorsal horn
5) Confidence 0.75 Published 2008 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 18477704 Disease Relevance 0.07 Pain Relevance 0.05
The binding of [(125)I] orexin-A (Ox-A) to particulates from Chinese hamster ovary (CHO) cells expressing the cloned orexin-A receptor, or from rat forebrain areas, was sensitive to blockers of phosphatidylinositol-specific phospholipase C (PtdIns-PLC) U-73122 and ET-18-OCH(3), little affected by phospholipase A(2) inhibitor quinacrine, and not sensitive to D609, a xanthate inhibitor of phosphatidylcholine-selective PLC.
Gene_expression (expressing) of orexin-A in ovary
6) Confidence 0.75 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10860858 Disease Relevance 0 Pain Relevance 0.07
Hypocretin-1 is expressed by hypothalamic neurons, which project to many regions of the central nervous system, including the nucleus ambiguus.
Gene_expression (expressed) of Hypocretin-1 in neurons associated with central nervous system
7) Confidence 0.70 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947034 Disease Relevance 0 Pain Relevance 0.13
The lateral hypothalamic region containing cells expressing MCH and hypocretin/orexin appears
Gene_expression (expressing) of hypocretin in lateral
8) Confidence 0.65 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0 Pain Relevance 0.04
It is also hypothesized that orexin/hypocretin neurons and CRF-expressing neurons constitute a feedback system which regulates arousal in response to stressful stimuli (Paneda et al. 2005; Winsky-Sommerer et al. 2003; 2005; Winsky-Sommerer et al. 2004).
Gene_expression (neurons) of hypocretin in neurons
9) Confidence 0.65 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0.18 Pain Relevance 0.25
Orexin-A and orexin-1 receptors are found in the dorsal root ganglion cells and the spinal dorsal horn and this suggests that orexin-A is involved in the spinal nociceptive transmission.
Gene_expression (found) of Orexin-A in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion and spinal dorsal horn
10) Confidence 0.65 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642783 Disease Relevance 0.55 Pain Relevance 0.49
Orexin-A and orexin-1 receptors are found in the dorsal root ganglion cells and the spinal dorsal horn and this suggests that orexin-A is involved in the spinal nociceptive transmission.
Gene_expression (found) of orexin in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion and spinal dorsal horn
11) Confidence 0.65 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642783 Disease Relevance 0.55 Pain Relevance 0.49
Orexin A and B (hypocretin 1 and 2) are the endogenous ligands of orexin receptors, a G-protein-coupled orphan receptor family containing orexin 1 (OX1) and orexin 2 (OX2) types.
Gene_expression (containing) of orexin
12) Confidence 0.65 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14551290 Disease Relevance 0.40 Pain Relevance 0.73
Orexin-A has been reported to produce an analgesic effect in the hot plate test and in the inflammatory pain models.
Gene_expression (produce) of Orexin-A associated with ipn and analgesic
13) Confidence 0.65 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12875916 Disease Relevance 0.46 Pain Relevance 0.80
Hypocretin-1 (1 microM) produced a significant increase in the frequency and amplitude of both GABAergic and glycinergic inhibitory postsynaptic currents and a significant decrease in the frequency of glutamatergic excitatory postsynaptic currents.
Gene_expression (produced) of Hypocretin-1 associated with gabaergic
14) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947034 Disease Relevance 0 Pain Relevance 0.32
Several brain regions involved in the central regulation of autonomic and endocrine processes or attention are targets of extensive hypocretin projections.
Gene_expression (projections) of hypocretin in autonomic
15) Confidence 0.59 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10545156 Disease Relevance 0 Pain Relevance 0.28
For example, the orexin/hypocretin peptides have been shown to induce dose-dependent activation of the HPA system; an effect that can be completely prevented using a CRF-1 receptor antagonist (Jaszberenyi et al. 2000), and recent data suggest that the CRF system directly innervates orexin/hypocretin expressing neurons (Winsky-Sommerer et al. 2005).
Gene_expression (expressing) of hypocretin in neurons associated with antagonist
16) Confidence 0.58 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0.43 Pain Relevance 0.27
MnPO is innervated by lateral hypothalamic neurons that synthesize and secrete the arousal-promoting and excitatory orexin (hypocretin) neuropeptides.
Gene_expression (synthesize) of hypocretin in MnPO associated with neuropeptide
17) Confidence 0.58 Published 2008 Journal Neuroscience Section Abstract Doc Link 18674591 Disease Relevance 0 Pain Relevance 0.14
MnPO is innervated by lateral hypothalamic neurons that synthesize and secrete the arousal-promoting and excitatory orexin (hypocretin) neuropeptides.
Gene_expression (synthesize) of orexin in MnPO associated with neuropeptide
18) Confidence 0.58 Published 2008 Journal Neuroscience Section Abstract Doc Link 18674591 Disease Relevance 0 Pain Relevance 0.14
Melanin-concentrating hormone (MCH) and orexin-A are orexigenic peptidergic neurotransmitters produced primarily in the lateral hypothalamus.
Gene_expression (produced) of orexin-A in hypothalamus associated with neurotransmitter
19) Confidence 0.58 Published 2002 Journal Endocrinology Section Abstract Doc Link 12130565 Disease Relevance 0.06 Pain Relevance 0.38
Intravenous injection of orexin-A produces an anti-thermal hyperalgesic effect in the carrageenan test and this effect of orexin-A was mediated by the activation of orexin-1 receptor at the peripheral primary afferent terminal.
Gene_expression (produces) of orexin-A associated with hyperalgesia
20) Confidence 0.58 Published 2007 Journal Masui Section Abstract Doc Link 17243644 Disease Relevance 0.40 Pain Relevance 0.46

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