INT81154

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.32
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HCRT) cytoplasm (HCRT)
Anatomy Link Frequency
neuronal 1
lateral 1
pituitary 1
head 1
HCRT (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 21 100.00 Very High Very High Very High
Migraine 6 100.00 Very High Very High Very High
Neuropeptide 13 99.10 Very High Very High Very High
Lasting pain 1 98.28 Very High Very High Very High
addiction 6 96.52 Very High Very High Very High
antagonist 11 92.64 High High
GABAergic 3 92.56 High High
agonist 4 86.84 High High
Neurotransmitter 19 85.84 High High
Spinal cord 7 79.92 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 300 100.00 Very High Very High Very High
Headache 27 100.00 Very High Very High Very High
Stress 15 98.84 Very High Very High Very High
Pain 3 98.28 Very High Very High Very High
Targeted Disruption 6 95.72 Very High Very High Very High
Autoimmune Disease 3 78.16 Quite High
Sleep Paralysis 12 75.60 Quite High
Hallucination 12 74.80 Quite High
Disease 32 73.68 Quite High
Lumbar Puncture Related Headaches 1 69.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypocretin (orexin) is synthesized by neurons in the lateral hypothalamus and has been reported to increase food intake and regulate the neuroendocrine system.
Gene_expression (synthesized) of orexin in lateral
1) Confidence 0.75 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10191330 Disease Relevance 0.12 Pain Relevance 0.21
Orexins, orexigenic neuropeptides, are secreted from lateral hypothalamus and orexin receptors are expressed in the pituitary.
Gene_expression (expressed) of orexin in pituitary associated with neuropeptide
2) Confidence 0.75 Published 2003 Journal Neuroendocrinology Section Abstract Doc Link 12673048 Disease Relevance 0 Pain Relevance 0.16
In this case the HTP analysis detected a region of phylogenetic inconsistency in the first cytosolic region between transmembranes 1 and 2 of the orexin receptors and the alpha-1B adrenergic receptor.
Gene_expression (receptors) of orexin
3) Confidence 0.65 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684142 Disease Relevance 0 Pain Relevance 0
Role of OX-1/Hcrt-1 receptors in operant self-administration of ethanol and sucrose
Gene_expression (/) of Hcrt
4) Confidence 0.65 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2668563 Disease Relevance 0 Pain Relevance 0.09
However, it is clear that mutations in the hypocretin (orexin) receptor 2 gene cause genetic narcolepsy in several animal species (Chemelli et al 1999; Lin et al 1999) and there is no doubt that hypocretin/orexin deficiency is the most frequent cause of narcolepsy with cataplexy in humans (Peyron et al 2000; Thannickal et al 2000).
Gene_expression (deficiency) of orexin associated with sleep disorders
5) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526380 Disease Relevance 1.23 Pain Relevance 0
There is no doubt that hypocretin/orexin deficiency is the cause of most narcolepsy in humans (Peyron et al 2000; Thannickal et al 2000).
Gene_expression (deficiency) of orexin associated with sleep disorders
6) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526380 Disease Relevance 0.60 Pain Relevance 0.13
However, it is clear that mutations in the hypocretin (orexin) receptor 2 gene cause genetic narcolepsy in several animal species (Chemelli et al 1999; Lin et al 1999) and there is no doubt that hypocretin/orexin deficiency is the most frequent cause of narcolepsy with cataplexy in humans (Peyron et al 2000; Thannickal et al 2000).
Gene_expression (deficiency) of orexin associated with sleep disorders
7) Confidence 0.65 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526380 Disease Relevance 1.17 Pain Relevance 0
The significantly higher orexin-A levels found in CM and MOH can be interpreted as a compensatory response to chronic head pain or, alternatively, as an expression of hypothalamic response to stress due to chronic pain.
Gene_expression (expression) of orexin in head associated with stress, lasting pain, migraine and headache
8) Confidence 0.65 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18479471 Disease Relevance 1.42 Pain Relevance 1.40
Both Orx/Hcrt and possibly glutamatergic non-Orx/Hcrt neurons in the PH in mice display W-specific neuronal activity (Takahashi et al., 2008).
Gene_expression (neurons) of Hcrt in neuronal
9) Confidence 0.65 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.06 Pain Relevance 0.20
Hcrt and its receptors encoded by Hcrtr-1 and Hcrtr-2 were sequenced in human patients with narcolepsy and a substitution mutation in Hcrt of a single patient was identified (Peyron et al. 2000).
Gene_expression (sequenced) of Hcrt associated with sleep disorders
10) Confidence 0.34 Published 2007 Journal Mamm Genome Section Body Doc Link PMC1998873 Disease Relevance 0.72 Pain Relevance 0.04

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