INT81155

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Context Info
Confidence 0.08
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.49
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CDCP1) plasma membrane (CDCP1)
Anatomy Link Frequency
neuronal 1
dorsal horn 1
CDCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
Dorsal horn neuron 1 100.00 Very High Very High Very High
Pain 13 98.52 Very High Very High Very High
central sensitization 2 96.40 Very High Very High Very High
Analgesic 1 87.48 High High
pain pelvic 1 69.40 Quite High
Inflammation 2 68.24 Quite High
Dorsal horn 1 67.52 Quite High
Central nervous system 2 66.76 Quite High
Peripheral sensitization 1 65.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Nociception 2 100.00 Very High Very High Very High
Pain 9 98.52 Very High Very High Very High
Injury 5 98.28 Very High Very High Very High
Neurodegenerative Disease 2 97.64 Very High Very High Very High
Breast Cancer 62 97.36 Very High Very High Very High
Ceroid Lipofuscinosis 1 95.36 Very High Very High Very High
Disease 15 87.20 High High
Infection 16 81.64 Quite High
Congenital Anomalies 22 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
which is capable of targeting both the EGFR and HER-2/neu tyrosine kinases that
Localization (targeting) of kinases
1) Confidence 0.08 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2668926 Disease Relevance 0.41 Pain Relevance 0
Prominent comparative findings include expansion of a novel family of 21 sequence-variant outer-membrane proteins, conservation of a type-III secretion virulence system, three serine/threonine protein kinases and a pair of parologous phospholipase-D-like proteins, additional purine and biotin biosynthetic capability, a homologue for aromatic amino acid (tryptophan) hydroxylase and the loss of tryptophan biosynthesis genes.
Localization (secretion) of kinases
2) Confidence 0.07 Published 1999 Journal Nat. Genet. Section Abstract Doc Link 10192388 Disease Relevance 1.41 Pain Relevance 0.10
In particular, mitogen-activated protein kinases (MAPKs), consisting of extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK), are downstream to many kinases and are activated in primary sensory and dorsal horn neurons by nociceptive activity, growth factors and inflammatory mediators, contributing to the induction and maintenance of pain sensitization via posttranslational, translational, and transcriptional regulation.
Localization (contributing) of kinases in dorsal horn associated with nociception, pain, inflammatory mediators and dorsal horn neuron
3) Confidence 0.02 Published 2007 Journal Handb Exp Pharmacol Section Abstract Doc Link 17087130 Disease Relevance 1.63 Pain Relevance 1.30
The product of DLGAP2 is a membrane-associated guanylate kinases localized at postsynaptic densities in neuronal cells.
Localization (localized) of kinases in neuronal
4) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2892449 Disease Relevance 0.86 Pain Relevance 0
Analysis of the steady state levels and sub-cellular localization of ectopically-expressed, epitope-tagged conserved herpesvirus protein kinases (CHPKs)
Localization (localization) of kinases
5) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.19 Pain Relevance 0

General Comments

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