INT81158

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HOXA10)
HOXA10 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 39 90.56 High High
Migraine 1 86.68 High High
Adalimumab 40 86.16 High High
Infliximab 11 76.84 Quite High
cva 1 25.00 Low Low
methotrexate 16 22.56 Low Low
Etanercept 6 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurological Disease 2 90.84 High High
Rheumatoid Arthritis 39 90.56 High High
Dementia 1 87.60 High High
Epilepsy 1 87.08 High High
Headache 1 86.68 High High
Stroke 1 86.28 High High
Disease 11 61.52 Quite High
Blister 1 61.20 Quite High
Apoptosis 4 60.96 Quite High
Bordatella Infection 1 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IgG from patients with high levels of aPL and neurological involvement was purified by protein-G affinity chromatography as was control IgG pooled from ten sera with low levels of aPL.
Positive_regulation (levels) of aPL
1) Confidence 0.06 Published 1999 Journal Lupus Section Abstract Doc Link 10192507 Disease Relevance 0.52 Pain Relevance 0.09
Induction of ANA, low-titer IgG/IgM anti-dsDNA but not aPL seems to be a drug-class-related effect, because increased antibody levels were found during treatment; however, no related clinical manifestations were recorded and antibody frequency was found to be lower than in studies with other TNF blocking agents.


Positive_regulation (Induction) of aPL
2) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526573 Disease Relevance 0.39 Pain Relevance 0.13

General Comments

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