INT81175

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 7.64
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pthlh) Golgi apparatus (Pthlh) nucleus (Pthlh)
intracellular (Pthlh) cytoplasm (Pthlh)
Anatomy Link Frequency
parathyroid 3
Pthlh (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 6 90.56 High High
melanocortin 1 receptor 1 90.08 High High
antagonist 10 82.32 Quite High
Pain 11 80.16 Quite High
agonist 1 53.76 Quite High
corticosteroid 2 49.68 Quite Low
cytokine 8 18.80 Low Low
chemokine 12 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 416 99.68 Very High Very High Very High
Hypoxia 231 99.66 Very High Very High Very High
Breast Cancer 114 99.48 Very High Very High Very High
Malignant Neoplastic Disease 5 99.30 Very High Very High Very High
Diabetes Mellitus 1 99.16 Very High Very High Very High
Hypercalcemia 91 99.02 Very High Very High Very High
Obesity 6 98.90 Very High Very High Very High
Osteoporosis 48 98.20 Very High Very High Very High
Disease 6 96.92 Very High Very High Very High
Metastasis 330 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in a preliminary characterisation of this model, we show that secretion of parathyroid hormone-related protein, a role for which has been implicated in breast cancer spread to bone, correlates with metastasis to bone.
Localization (secretion) of hormone-related protein in parathyroid associated with breast cancer and metastasis
1) Confidence 0.70 Published 1999 Journal Clin. Exp. Metastasis Section Abstract Doc Link 10411109 Disease Relevance 1.61 Pain Relevance 0
First, in contrast to myeloma patients with hypercalcemia, in which PTHrP is implicated only sporadically, humoral hypercalcemia of malignancy is almost always due to excessive secretion of PTHrP by the tumor, resulting in elevated circulating levels.
Localization (secretion) of PTHrP associated with malignant neoplastic disease, cancer and hypercalcemia
2) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 1.38 Pain Relevance 0
and hypoxia-regulated genes selected from Table 1: VEGF; CXCR4; PTHrP; IL-6, 8, 11; and CTGF.
Localization (selected) of PTHrP associated with hypoxia
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.18 Pain Relevance 0
Breast cancers that metastasize to bone secrete factors, such as parathyroid hormone-related protein (PTHrP) and interleukin-11 (IL-11), that stimulate osteoclastic bone destruction and the release and activation of growth factors immobilized in the bone matrix.
Localization (secrete) of PTHrP in parathyroid associated with breast cancer and osteoporosis
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.38 Pain Relevance 0.17
Breast cancers that metastasize to bone secrete factors, such as parathyroid hormone-related protein (PTHrP) and interleukin-11 (IL-11), that stimulate osteoclastic bone destruction and the release and activation of growth factors immobilized in the bone matrix.
Localization (secrete) of parathyroid hormone-related protein in parathyroid associated with breast cancer and osteoporosis
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.37 Pain Relevance 0.17
The Avy/-agouti mouse, one of the oldest obese mouse models, is characterized by maturity-onset obesity and diabetes as a result of ectopic expression of the secreted protein hormone, agouti protein.
Localization (secreted) of protein hormone associated with diabetes mellitus and obesity
6) Confidence 0.04 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193863 Disease Relevance 0.72 Pain Relevance 0.16

General Comments

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