INT81187

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Vipr2) plasma membrane (Vipr2) signal transducer activity (Vipr2)
Anatomy Link Frequency
neurons 1
dorsal root ganglion 1
Vipr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nerve injury 1 99.26 Very High Very High Very High
spinal dorsal horn 1 98.92 Very High Very High Very High
dorsal root ganglion 1 98.46 Very High Very High Very High
Eae 9 97.68 Very High Very High Very High
Somatostatin 1 93.76 High High
Analgesic 1 90.88 High High
Lasting pain 1 89.20 High High
antagonist 5 88.32 High High
Dorsal horn 2 80.08 Quite High
agonist 3 66.48 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 99.26 Very High Very High Very High
Ganglion Cysts 1 98.46 Very High Very High Very High
Injury 4 96.84 Very High Very High Very High
Pain 1 89.20 High High
Diabetic Nephropathy 1 75.00 Quite High
Targeted Disruption 1 48.56 Quite Low
Neuropathic Pain 2 33.60 Quite Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The SCN target of VIP, the VPAC2 receptor, is heavily expressed in all regions/divisions of the SCN, indicating VIPĀ–VPAC2 signaling to be influential in intercellular signaling between SCN neurons (Kalamatianos et al. 2004; Kallo et al. 2004).
Regulation (target) of VPAC2 receptor in neurons
1) Confidence 0.27 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2658715 Disease Relevance 0 Pain Relevance 0.13
Since vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are up-regulated in dorsal root ganglion cells following peripheral nerve injury, we investigated the expression and influence of VPAC1, VPAC2 and PAC1 receptors in rat spinal dorsal horn following a chronic constriction injury (CCI).
Spec (investigated) Regulation (influence) of VPAC2 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury, eae, spinal dorsal horn, injury and peripheral nerve injury
2) Confidence 0.03 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10193908 Disease Relevance 0.78 Pain Relevance 0.70

General Comments

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