INT81194

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 40
Total Number 41
Disease Relevance 23.70
Pain Relevance 18.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) oxidoreductase activity (CPOX)
cytoplasm (CPOX)
Anatomy Link Frequency
blood 2
leukocytes 2
plasma 1
platelet 1
Caki-1 1
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 463 100.00 Very High Very High Very High
COX-2 inhibitor 53 100.00 Very High Very High Very High
rheumatoid arthritis 52 100.00 Very High Very High Very High
cOX1 26 100.00 Very High Very High Very High
Osteoarthritis 18 100.00 Very High Very High Very High
COX2 43 99.96 Very High Very High Very High
cytokine 109 99.84 Very High Very High Very High
aspirin 48 99.64 Very High Very High Very High
Pain 70 99.60 Very High Very High Very High
Inflammation 578 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 52 100.00 Very High Very High Very High
Osteoarthritis 18 100.00 Very High Very High Very High
Skin Cancer 13 100.00 Very High Very High Very High
Coagulation Disorder 2 99.70 Very High Very High Very High
Cancer 444 99.68 Very High Very High Very High
Neuroma 12 99.66 Very High Very High Very High
Pain 69 99.60 Very High Very High Very High
INFLAMMATION 708 99.52 Very High Very High Very High
Apoptosis 216 99.32 Very High Very High Very High
Disease 125 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of action of NSAIDs generally involves the inhibition of cyclooxygenase (COX) at sites of inflammation.
COX Neg (inhibition) Binding (inhibition) of associated with inflammation and cinod
1) Confidence 0.29 Published 2008 Journal Mod Rheumatol Section Abstract Doc Link 18642053 Disease Relevance 1.31 Pain Relevance 1.00
Although most NSAIDs inhibit the activity of cyclooxygenase (COX), the rate-limiting enzyme in the production of prostanoids from arachidonic acid (AA), the precise mechanism through which NSAIDs act upon AD pathology remains to be elucidated.
COX Neg (inhibit) Binding (activity) of associated with cinod and disease
2) Confidence 0.26 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 0.75 Pain Relevance 0.47
These studies have used 'traditional' NSAIDs and their metabolites which either do not inhibit COX, are non-selective for the COX isoforms or selectively inhibit COX-1 over COX-2, and recently developed NSAIDs that are highly selective for COX-2.
COX Neg (inhibit) Binding (non-selective) of associated with cinod
3) Confidence 0.21 Published 1999 Journal Apoptosis Section Abstract Doc Link 14634339 Disease Relevance 0.92 Pain Relevance 0.96
Moreover, accumulating evidence suggests a role for COX-2 in Alzheimer's disease and colorectal cancer.
COX Binding (role) of associated with colon cancer and disease
4) Confidence 0.17 Published 1998 Journal J Clin Rheumatol Section Abstract Doc Link 19078322 Disease Relevance 0.41 Pain Relevance 0.38
Patients at risk of CV disease or with a history of CV disease were the most significant determinants of CV events after receiving COX inhibitors.
COX Binding (receiving) of associated with disease
5) Confidence 0.15 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18812633 Disease Relevance 1.13 Pain Relevance 0.40
Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging.
COX Binding (target) of associated with cox2 and imagery
6) Confidence 0.15 Published 2003 Journal Mol Imaging Biol Section Title Doc Link 14630509 Disease Relevance 0.18 Pain Relevance 0.42
Topical NSAIDs differ based on their affinity for the COX enzyme and activity in terms of enzyme inhibition.
COX enzyme Binding (affinity) of associated with cinod
7) Confidence 0.13 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693998 Disease Relevance 0.07 Pain Relevance 0.92
Coagulation-induced thromboxane B(2) and lipopolysaccharide-induced prostaglandin E(2) were measured ex vivo and in vitro in human whole blood as indices of COX-1 and COX-2 activity.
COX Binding (indices) of in blood
8) Confidence 0.13 Published 2008 Journal FASEB J. Section Abstract Doc Link 17884974 Disease Relevance 0 Pain Relevance 0.81
Coagulation-induced thromboxane B(2) and lipopolysaccharide-induced prostaglandin E(2) were measured ex vivo and in vitro in human whole blood as indices of COX-1 and COX-2 activity.
COX Binding (indices) of in blood
9) Confidence 0.13 Published 2008 Journal FASEB J. Section Abstract Doc Link 17884974 Disease Relevance 0 Pain Relevance 0.81
After reacting with anti-COX-1 and anti-COX-2 immunoglobulin G, the presence of both immunoreactive COX enzymes was substantiated using an indirect immunoperoxidase method.
COX Binding (reacting) of
10) Confidence 0.13 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977131 Disease Relevance 0.09 Pain Relevance 0.28
After reacting with anti-COX-1 and anti-COX-2 immunoglobulin G, the presence of both immunoreactive COX enzymes was substantiated using an indirect immunoperoxidase method.
COX Binding (reacting) of
11) Confidence 0.13 Published 2000 Journal J Ocul Pharmacol Ther Section Abstract Doc Link 10977131 Disease Relevance 0.09 Pain Relevance 0.28
compounds showing dual inhibition of LOX-5 and COX-2 such as
COX Binding (compounds) of
12) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.75 Pain Relevance 0.34
The parallel measurement of TXB2 production during whole blood clotting is used as an index of platelet COX-1 activity (Patrono et al 1980).
COX Binding (index) of in platelet associated with coagulation disorder
13) Confidence 0.12 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.10 Pain Relevance 0.15
We review the various in vitro test systems available for the measurement of COX-1 and COX-2 inhibition.
COX Binding (measurement) of
14) Confidence 0.12 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973430 Disease Relevance 0.14 Pain Relevance 0.24
We review the various in vitro test systems available for the measurement of COX-1 and COX-2 inhibition.
COX Binding (measurement) of
15) Confidence 0.12 Published 1999 Journal Drugs Today Section Abstract Doc Link 12973430 Disease Relevance 0.14 Pain Relevance 0.24
Keeping this in mind, we have used the X-ray crystal structures of the complexes of the COX-1 and COX-2 with the known inhibitors for a rational, structure based approach to design a small peptide, which is potent inhibitor for COX-2.
COX Binding (complexes) of
16) Confidence 0.11 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17640617 Disease Relevance 0.31 Pain Relevance 0.42
Keeping this in mind, we have used the X-ray crystal structures of the complexes of the COX-1 and COX-2 with the known inhibitors for a rational, structure based approach to design a small peptide, which is potent inhibitor for COX-2.
COX Binding (complexes) of
17) Confidence 0.11 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17640617 Disease Relevance 0.31 Pain Relevance 0.42
studies have shown COX-2 constitutive expression in normal tissues, where it
COX Binding (shown) of
18) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2652614 Disease Relevance 0.58 Pain Relevance 0.33
In addition, an association between COX-2, its main product PGE2 and aromatase activity in human breast cancer suggests that such inhibitors might have an additional, specific prophylactic mechanism for this tumour.
COX Binding (association) of associated with cancer and breast cancer
19) Confidence 0.10 Published 2002 Journal Ann. Oncol. Section Abstract Doc Link 12075734 Disease Relevance 0.73 Pain Relevance 0.38
Animal and human data demonstrate that cyclooxygenase (COX)-2 upregulation in osteoarthritis and rheumatoid arthritis is associated with the pain and inflammation of the disease state.
COX Binding (associated) of associated with pain, inflammation, rheumatoid arthritis, disease and osteoarthritis
20) Confidence 0.10 Published 1999 Journal Am J. Orthop. Section Abstract Doc Link 10193997 Disease Relevance 0.86 Pain Relevance 0.45

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