INT81195

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 1.28
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Bcmo1)
Anatomy Link Frequency
EPI 2
cavity 1
Bcmo1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 100.00 Very High Very High Very High
tramadol 7 99.58 Very High Very High Very High
lidocaine 6 95.96 Very High Very High Very High
Inflammation 24 94.84 High High
Analgesic 3 94.08 High High
Angina 1 89.04 High High
beta blocker 2 86.68 High High
local anesthetic 5 83.92 Quite High
Pain 2 78.64 Quite High
epidural 2 77.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 46 100.00 Very High Very High Very High
Cv General 3 Under Development 1 89.04 High High
Hypertension 1 88.24 High High
Stress 1 81.60 Quite High
Lung Cancer 7 70.36 Quite High
Nicotine Addiction 15 65.04 Quite High
Targeted Disruption 7 50.00 Quite Low
Pain 2 38.08 Quite Low
Communicable Diseases 1 37.96 Quite Low
Infection 7 35.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First of all, BC metabolism in humans is highly variable [16, 17] and most of this variability can be attributed to differences in enzymatic activity of the beta-carotene 15,15?
beta-carotene Binding (activity) of
1) Confidence 0.33 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.51 Pain Relevance 0
In addition, the study of the apparent stability constant by HPLC and solubility isotherm gives thermodynamics information about the interaction between S(--) bvc and HP-beta-CD.
HP-beta-CD Binding (interaction) of
2) Confidence 0.32 Published 2007 Journal Int J Pharm Section Abstract Doc Link 17071028 Disease Relevance 0 Pain Relevance 0.08
Complexation was highest with HP-beta-CD and malt-beta-CD, much higher than with SBE-7-beta-CD, with stability constants at pH 8.0 of 801, 729 and 1309 M(-1), respectively.
HP-beta-CD Binding (highest) of
3) Confidence 0.25 Published 2003 Journal Int J Pharm Section Abstract Doc Link 14522114 Disease Relevance 0 Pain Relevance 0.23
From the enthalpy and entropy changes, it appeared that nimesulide interact more strongly with HP-beta-CD due to a significant hydrophobic effect between the compound and the flexible hydroxypropyl groups.
HP-beta-CD Spec (appeared) Binding (interact) of
4) Confidence 0.20 Published 2002 Journal J Pharm Biomed Anal Section Abstract Doc Link 12062643 Disease Relevance 0.06 Pain Relevance 0.09
The inclusion complex formation between neutral or protonated novocaine and beta-CD of 1:1 stoichiometry was observed; however, the magnitude of the binding constants depends on the nature of both the guest and the host, and the higher-affinity guest-host was found under conditions when both the novocaine and the beta-CD were neutral molecules.
beta-CD Binding (formation) of
5) Confidence 0.14 Published 2006 Journal J. Org. Chem. Section Abstract Doc Link 16749765 Disease Relevance 0 Pain Relevance 0.08
The present study describes the complexation of NM with beta-cyclodextrin (beta-CD) and its derivative hydroxypropyl beta-cyclodextrin (HP beta-CD).
beta-CD Binding (complexation) of
6) Confidence 0.10 Published 1999 Journal Drug Dev Ind Pharm Section Abstract Doc Link 10194611 Disease Relevance 0.10 Pain Relevance 0.19
The in vitro dissolution rate of drug-HP beta-CD complex was faster compared to the drug-beta-CD complex and drug alone.
beta-CD Binding (complex) of
7) Confidence 0.09 Published 1999 Journal Drug Dev Ind Pharm Section Abstract Doc Link 10194611 Disease Relevance 0.08 Pain Relevance 0.16
These effects are mainly attributed to a preferential drug/beta-CD interaction (except for PB), which, at least in the conditions studied here, explains the higher beta-CD concentration needed for micellar breakup to occur.
beta-CD Neg (except) Binding (interaction) of
8) Confidence 0.08 Published 2010 Journal Langmuir Section Abstract Doc Link 20465298 Disease Relevance 0 Pain Relevance 0.27
Spectroscopic and molecular modeling techniques have been employed to study the interaction of the oxicam group of nonsteroidal antiinflammatory drugs (NSAIDs) with a polysaccharide such as beta-cyclodextrin (beta-cd). beta-cd is a good drug delivery system and is known to reduce harmful side effects of these drugs in the gastrointestinal tract and to increase their clinical efficacy.
beta-cd Binding (interaction) of associated with inflammation and cinod
9) Confidence 0.07 Published 2004 Journal Biopolymers Section Abstract Doc Link 15372483 Disease Relevance 0.10 Pain Relevance 0.17
The obtained results confirmed that complexation of BVP HCl with beta-CD and EPI-beta-CD is a suitable tool for properly tailoring the dissolution properties of the drug and it can be favourably exploited for the development of an effective buccal drug delivery system.
beta-CD Binding (complexation) of in EPI
10) Confidence 0.07 Published 2010 Journal J Pharm Biomed Anal Section Abstract Doc Link 20004541 Disease Relevance 0 Pain Relevance 0
The obtained results confirmed that complexation of BVP HCl with beta-CD and EPI-beta-CD is a suitable tool for properly tailoring the dissolution properties of the drug and it can be favourably exploited for the development of an effective buccal drug delivery system.
beta-CD Binding (complexation) of in EPI
11) Confidence 0.07 Published 2010 Journal J Pharm Biomed Anal Section Abstract Doc Link 20004541 Disease Relevance 0 Pain Relevance 0
However, in beta-CD, due to space restriction of the CD cavity, a weak interaction is present between the above groups in tramadol. beta-Cyclodextrin studies show that tramadol forms 1:2 inclusion complex with beta-CD.
beta-CD Binding (complex) of in cavity associated with tramadol
12) Confidence 0.06 Published 2009 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 19665424 Disease Relevance 0 Pain Relevance 0.60
Resolution of three of the four stereoisomers of nadolol was obtained previously by HPLC, with a complete separation of the most active enantiomer (RSR)-nadolol, on a column packed with perphenyl carbamoylated beta-cyclodextrin (beta-CD) immobilized onto silica gel.
beta-CD Binding (packed) of
13) Confidence 0.04 Published 2004 Journal J Chromatogr A Section Abstract Doc Link 15124810 Disease Relevance 0.18 Pain Relevance 0.17
By means of HPLC and UV-vis measurements and quantum mechanics calculations, it was found that MS and ES form a 1:1 inclusion complex with betaCD.
betaCD Binding (complex) of
14) Confidence 0.03 Published 2008 Journal J Pharm Biomed Anal Section Abstract Doc Link 18650048 Disease Relevance 0 Pain Relevance 0
The complexation with betaCD has been investigated using reversed-phase liquid chromatography.
betaCD Binding (complexation) of
15) Confidence 0.02 Published 2008 Journal J Pharm Biomed Anal Section Abstract Doc Link 18650048 Disease Relevance 0.09 Pain Relevance 0.14
The low solubility of MS and ES in aqueous solution has been improved by complexation with betaCD (1-9 mM).
betaCD Binding (complexation) of
16) Confidence 0.02 Published 2008 Journal J Pharm Biomed Anal Section Abstract Doc Link 18650048 Disease Relevance 0.06 Pain Relevance 0.10
The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state.
beta-CD Binding (interactions) of associated with inflammation and cinod
17) Confidence 0.01 Published 2002 Journal J Pharm Biomed Anal Section Abstract Doc Link 12039640 Disease Relevance 0.10 Pain Relevance 0.10
For complex 4, which forms stable inclusion complex with beta-CD, the biosensor sensitivity was the highest and equal to 7.2 micro A mM(-1) cm(-2), detectability was as low as 1 mM, but the linear concentration range was limited only to 4 mM.
beta-CD Binding (complex) of
18) Confidence 0.00 Published 2002 Journal Anal Bioanal Chem Section Abstract Doc Link 12194030 Disease Relevance 0 Pain Relevance 0.07

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