INT812

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2011
Negated 5
Speculated 4
Reported most in Abstract
Documents 1026
Total Number 1032
Disease Relevance 515.60
Pain Relevance 145.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 44
plasma 25
pancreas 25
beta cell 22
pancreatic islets 19
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 748 100.00 Very High Very High Very High
headache 240 100.00 Very High Very High Very High
Neuropeptide 210 100.00 Very High Very High Very High
Clonidine 163 100.00 Very High Very High Very High
Cholecystokinin 162 100.00 Very High Very High Very High
Enkephalin 114 100.00 Very High Very High Very High
Bile 82 100.00 Very High Very High Very High
Chronic pancreatitis 65 100.00 Very High Very High Very High
pregabalin 4 100.00 Very High Very High Very High
tolerance 1801 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 31872 100.00 Very High Very High Very High
Hypoglycemia 5654 100.00 Very High Very High Very High
Insulin Resistance 3368 100.00 Very High Very High Very High
Disease 2931 100.00 Very High Very High Very High
Hyperglycemia 1971 100.00 Very High Very High Very High
Cancer 1511 100.00 Very High Very High Very High
Hyperinsulinism 1073 100.00 Very High Very High Very High
Metabolic Syndrome 955 100.00 Very High Very High Very High
Pancreatitis 658 100.00 Very High Very High Very High
Targeted Disruption 555 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, because oral HIM-2 is delivered to the liver through the portal circulation thereby reproducing the physiological route of insulin secretion, oral HIM-2 may result in avoidance of pheripheral hyperinsulinemia.11 Pulmonary delivery of insulin is feasible given the large surface area and high permeability of the lungs where insulin can be effectively absorbed via the pulmonary alveoli.12 However, the inhalable insulin, Exubera®, approved for use in 2006 as the first available alternative to insulin injections, was taken off the market less than two years later due to limited adoption by patients.
Localization (secretion) of insulin in lungs associated with hyperinsulinism
1) Confidence 0.81 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915552 Disease Relevance 0.26 Pain Relevance 0.04
CONCLUSIONS/INTERPRETATION: Insulin secretion is diminished after pancreatic-head and -tail resection, but post-challenge glucose concentrations can be ameliorated after pancreatic-head resection.
Localization (secretion) of Insulin in tail
2) Confidence 0.81 Published 2009 Journal Diabetologia Section Body Doc Link 19037627 Disease Relevance 0 Pain Relevance 0
We examined the effects of approximately 50% partial pancreatectomy on glucose homeostasis and insulin secretion.
Localization (secretion) of insulin
3) Confidence 0.81 Published 2009 Journal Diabetologia Section Abstract Doc Link 19037627 Disease Relevance 0.18 Pain Relevance 0.09
Although a carbohydrate meal itself lacks tryptophan, the meal causes insulin to be secreted.
Localization (secreted) of insulin
4) Confidence 0.81 Published 1984 Journal Nutr Health Section Abstract Doc Link 6400041 Disease Relevance 0.06 Pain Relevance 0.28
The patients had a mean C-peptide level of 0.19 pmol/ml, indicating that these patients had negligible insulin secretion.
Localization (secretion) of insulin
5) Confidence 0.81 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772019 Disease Relevance 0.26 Pain Relevance 0
Various parameters of the insulin secretion in man may be appreciated and calculated by studying the insulin response to an intravenous pulse of glucose followed 120 minutes later by one of tolbutamide.
Localization (secretion) of insulin
6) Confidence 0.81 Published 1976 Journal Nouv Presse Med Section Abstract Doc Link 794823 Disease Relevance 0.22 Pain Relevance 0.06
[A method of studying insulin secretion in humans: the glucose stimulation test, followed by tolbutamide].
Localization (secretion) of insulin
7) Confidence 0.81 Published 1976 Journal Nouv Presse Med Section Title Doc Link 794823 Disease Relevance 0.25 Pain Relevance 0.07
Prostaglandin E (PGE), epinephrine and metenkephalin are three endogenous substances normally present in the endocrine pancreas which have been reported to inhibit glucose-induced insulin secretion in normal humans.
Localization (secretion) of insulin in endocrine pancreas
8) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0 Pain Relevance 0.16
Similarly, the negative effect of FK 33-824 upon glucose-induced insulin secretion was reversed by sodium salicylate.
Localization (secretion) of insulin
9) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0.18 Pain Relevance 0.13
The infusion of the three agents at doses known to affect insulin secretion (10 micrograms/min, 15 ng/kg/min, 0.5 mg im, respectively) produced the expected inhibitory effects upon insulin responses to an intravenous glucose challenge.
Localization (secretion) of insulin
10) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0.06 Pain Relevance 0.17
The inhibitory effect of epinephrine (15 ng/kg/min) upon glucose-induced insulin secretion was partially reversed by sodium salicylate, an inhibitor of endogenous prostaglandin synthesis, which increased but not normalized, either the acute insulin response and the glucose disappearance rates.
Localization (secretion) of insulin associated with hyperinsulinism
11) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0.19 Pain Relevance 0.14
To evaluate possible synergistic interactions between these inhibitory agents upon the regulation of insulin release in man, we examined the effects of PGE, epinephrine and the long-acting met-enkephalin analogue FK 33-824, given alone or in combination, upon glucose-induced insulin secretion in normal man.
Localization (release) of insulin associated with enkephalin
12) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0 Pain Relevance 0.17
Interaction between epinephrine, prostaglandin E, and met-enkephalin in the regulation of insulin release in man.
Localization (release) of insulin associated with enkephalin
13) Confidence 0.81 Published 1985 Journal Diabete Metab Section Title Doc Link 3908178 Disease Relevance 0.06 Pain Relevance 0.18
To evaluate possible synergistic interactions between these inhibitory agents upon the regulation of insulin release in man, we examined the effects of PGE, epinephrine and the long-acting met-enkephalin analogue FK 33-824, given alone or in combination, upon glucose-induced insulin secretion in normal man.
Localization (secretion) of insulin associated with enkephalin
14) Confidence 0.81 Published 1985 Journal Diabete Metab Section Abstract Doc Link 3908178 Disease Relevance 0.06 Pain Relevance 0.17
Thus, these findings indicate that impaired insulin secretion during surgical stress may have two etiologies--one related to the type of anesthesia used and the other due to adrenomedullary stimulation due to pain.
Localization (secretion) of insulin associated with stress, pain and anesthesia
15) Confidence 0.81 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.63 Pain Relevance 0.60
In the postoperative period, however, suppressed insulin secretion was found to be correlated with elevated plasma epinephrine concentrations and may, therefore, be mediated by adrenergic mechanisms.
Localization (secretion) of insulin in plasma
16) Confidence 0.81 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.56 Pain Relevance 0.59
Thus, these changes in insulin secretion are not attributable to adrenergic mechanisms.
Localization (secretion) of insulin
17) Confidence 0.81 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.57 Pain Relevance 0.59
Effects of anesthesia and surgical stress on insulin secretion in man.
Localization (secretion) of insulin associated with stress and anesthesia
18) Confidence 0.81 Published 1980 Journal Metab. Clin. Exp. Section Title Doc Link 7001179 Disease Relevance 0.63 Pain Relevance 0.63
Surgical stress with inhalation anesthesia is associated with increased circulating catecholamines, hyperglycemia, and impaired insulin secretion.
Localization (secretion) of insulin associated with hyperglycemia, stress, anesthesia and catecholamine
19) Confidence 0.81 Published 1980 Journal Metab. Clin. Exp. Section Abstract Doc Link 7001179 Disease Relevance 0.54 Pain Relevance 0.49
The effects of bromocriptine (CB-154, 2.5 mg po), clonidine (0.05 mg im) and naloxone (0.4 mg im), as well as the interaction between naloxone and CB-154 or clonidine on basal insulin secretion were studied in 6 normal men.
Localization (secretion) of insulin associated with narcan and clonidine
20) Confidence 0.81 Published 1981 Journal J. Endocrinol. Invest. Section Abstract Doc Link 7037921 Disease Relevance 0 Pain Relevance 0.87

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