INT81210

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 71
Total Number 72
Disease Relevance 26.83
Pain Relevance 19.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
spinal cord 4
tail 3
spinal 3
synapses 3
colon 3
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 200 100.00 Very High Very High Very High
Hyperalgesia 47 99.90 Very High Very High Very High
analgesia 8 99.90 Very High Very High Very High
Rostral ventrolateral medulla 440 99.84 Very High Very High Very High
dorsal root ganglion 105 99.64 Very High Very High Very High
Spinal cord 95 99.60 Very High Very High Very High
antinociception 8 99.54 Very High Very High Very High
antagonist 32 99.46 Very High Very High Very High
depression 131 99.42 Very High Very High Very High
hyperexcitability 60 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 563 99.90 Very High Very High Very High
Hyperalgesia 58 99.90 Very High Very High Very High
Apoptosis 303 99.68 Very High Very High Very High
Ganglion Cysts 122 99.64 Very High Very High Very High
Nociception 107 99.56 Very High Very High Very High
Depression 129 99.42 Very High Very High Very High
Injury 81 99.36 Very High Very High Very High
Hypertension 21 99.36 Very High Very High Very High
Neuropathic Pain 96 98.96 Very High Very High Very High
Colon Cancer 55 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather, PKG I induced by exisulind may mediate desensitization of cytostasis induced by cGMP.
Positive_regulation (induced) of PKG I
1) Confidence 0.70 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.71 Pain Relevance 0.09
Further, although exisulind induced expression of PKG Ibeta, it did not elevate intracellular cGMP and its efficacy was not altered by inhibition or activation of PKG I.
Positive_regulation (activation) of PKG I
2) Confidence 0.70 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.71 Pain Relevance 0.10
Chemically induced, activity-independent LTD elicited by simultaneous activation of PKG and inhibition of PKA.
Positive_regulation (activation) of PKG
3) Confidence 0.67 Published 1999 Journal J. Neurophysiol. Section Title Doc Link 10482771 Disease Relevance 0.64 Pain Relevance 0.46
However, coapplication of H-89 plus zaprinast converted this to a robust LTD that depended critically on activation of cyclic GMP-dependent protein kinase (PKG).
Positive_regulation (activation) of PKG associated with depression
4) Confidence 0.67 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10482771 Disease Relevance 0.83 Pain Relevance 0.62
This is associated with phosphorylation of the protein VASP, a marker of PKG activation, activation of JNK1 and a decrease in cellular levels of cyclin D1; effects seen with other agents that cause activation of PKG in these cells.
Positive_regulation (activation) of PKG
5) Confidence 0.63 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.37 Pain Relevance 0.26
Nor did rofecoxib inhibit cGMP-PDE activity or cause other changes related to PKG activation in these cells.
Positive_regulation (activation) of PKG
6) Confidence 0.63 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.33 Pain Relevance 0.25
This is associated with phosphorylation of the protein VASP, a marker of PKG activation, activation of JNK1 and a decrease in cellular levels of cyclin D1; effects seen with other agents that cause activation of PKG in these cells.
Positive_regulation (activation) of PKG
7) Confidence 0.63 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.39 Pain Relevance 0.22
Since activation of the PKG pathways by celecoxib, indomethacin, and meclofenamic acid in this cell culture system required high concentrations of these compounds, it remains to be determined whether activation of this pathway contributes to the in vivo antitumor effects of specific NSAIDs.
Positive_regulation (activation) of PKG associated with cinod
8) Confidence 0.63 Published 2008 Journal Mol. Carcinog. Section Abstract Doc Link 18163459 Disease Relevance 0.33 Pain Relevance 0.26
Sulindac metabolites simultaneously (a) increase cellular cyclic GMP and subsequently activate cyclic GMP-dependent protein kinase (PKG); (b) activate c-jun NH2-terminal kinase (JNK); (c) inhibit extracellular signal-regulated kinase 1/2 (ERK1/2); and (d) decrease beta-catenin protein expression at times and doses consistent with apoptosis.
Positive_regulation (activate) of PKG associated with apoptosis
9) Confidence 0.53 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.88 Pain Relevance 0.18
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Positive_regulation (activation) of PKG in colon associated with colon cancer and apoptosis
10) Confidence 0.53 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.06 Pain Relevance 0.14
Probably the most widespread mechanism employed by cGMP is activation of PKG, which exists in three forms, PKG1?
Positive_regulation (activation) of PKG
11) Confidence 0.49 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.12
Here we report that noxious stimulation of the mollusc Aplysia produces transcription-dependent, long-term hyperexcitability (LTH) of nociceptive sensory neurons that requires a nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway.
Positive_regulation (requires) of PKG in sensory neurons associated with nociception and hyperexcitability
12) Confidence 0.49 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10195175 Disease Relevance 0.17 Pain Relevance 0.44
is concentrated in cerebellum and dorsal root ganglia and PKG1?
Positive_regulation (concentrated) of PKG in dorsal root ganglia
13) Confidence 0.49 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610389 Disease Relevance 0 Pain Relevance 0.13
Inhibition by specific antagonists indicates that continuing activation of cAMP-PKA and cGMP-PKG pathways is required to maintain hyperexcitability after dissociation.
Positive_regulation (activation) of PKG associated with antagonist and hyperexcitability
14) Confidence 0.45 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17021029 Disease Relevance 0.33 Pain Relevance 0.67
While adenosine couples directly to PKC through the phospholipases, bradykinin and opioids do so through a complex pathway that includes in order: phosphatidylinositol 3-kinase (PI3-kinase), Akt, nitric oxide synthase, guanylyl cyclase, PKG, opening of mitochondrial K(ATP) channels, and activation of PKC by redox signaling.
Positive_regulation (activation) of PKG associated with adenocard, opioid and bradykinin
15) Confidence 0.45 Published 2007 Journal Heart Fail Rev Section Abstract Doc Link 17516169 Disease Relevance 0.16 Pain Relevance 0.58
KCNMA1 activation has a great impact on the membrane and plays role in muscle tone/contractility and neuronal activity [32] as well as blood pressure regulation [33]; (b) PRKG1, a serine-threonine kinase located in the cytoplasm with a key role in nitric oxide/cyclic guanosine monophosphate (cGMP) signaling.
Positive_regulation (activation) of PRKG1 in blood
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.41 Pain Relevance 0
is mediated, at least in part, through both PKG and PKC-catalysed mechanisms where Ser331 and Ser145/Thr337 located within IC2 and C-tail domains have been identified as the respective phospho-targets.
Positive_regulation (mediated) of PKG in tail
17) Confidence 0.22 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Hence, in addition to the agonist-mediated PKC-feedback mechanism, engagement of the NO-cGMP signalling pathway through U46619-activation of the NOS/sGC/PKG pathway plays a significant role in inducing homologous desensitization of TP?
Neg (NO) Positive_regulation (activation) of PKG associated with agonist
18) Confidence 0.22 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.16
NO, in turn, activates the soluble form of guanylate cyclase (sGC) leading to a rise in intracellular cGMP and activation of PKG [52–55].
Positive_regulation (activation) of PKG
19) Confidence 0.21 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.04
In a colon cancer cell line Exisulind showed induction of apoptosis as a result of its ability to inhibit cGMP-dependent phosphodiesterase (PDE), followed by elevated cGMP-levels and increased proteinkinase G (PKG) activity [20].
Positive_regulation (elevated) of PKG in colon associated with colon cancer and apoptosis
20) Confidence 0.20 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 1.11 Pain Relevance 0.15

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