INT81211

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.05
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
spine 1
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 6 100.00 Very High Very High Very High
antidepressant 1 99.56 Very High Very High Very High
Pyramidal cell 1 99.16 Very High Very High Very High
Glutamate 4 96.00 Very High Very High Very High
Deafferentation 1 94.08 High High
tetrodotoxin 1 89.76 High High
Prostatitis 2 89.56 High High
Calcium channel 3 85.76 High High
pain pelvic 1 75.00 Quite High
Angina 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Dysphagia 5 99.80 Very High Very High Very High
Esophageal Motility Disorder 6 98.28 Very High Very High Very High
Disease 1 93.20 High High
Reprotox - General 1 2 89.56 High High
Diffuse Esophageal Spasm 3 89.24 High High
Rare Diseases 1 83.08 Quite High
Overactive Bladder 3 75.88 Quite High
Reprotox - General 3 1 75.00 Quite High
Gastroesophageal Reflux Disease 1 37.28 Quite Low
Diverticulum 1 35.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of botulinum toxin for achalasia, medical therapy of primary esophageal motility disorders is rather limited and the clinical results are poor.
Neg (exception) Transcription (exception) of botulinum toxin associated with esophageal motility disorder and dysphagia
1) Confidence 0.54 Published 1999 Journal Dis. Esophagus Section Abstract Doc Link 10770358 Disease Relevance 0.64 Pain Relevance 0.27
With the exception of botulinum toxin, however, few new therapies have emerged showing clinical benefits.
Neg (exception) Transcription (exception) of botulinum toxin
2) Confidence 0.54 Published 2007 Journal Curr Opin Urol Section Body Doc Link 17558263 Disease Relevance 0.08 Pain Relevance 0
In addition, multiple interventional techniques including the injection of botulinum toxin, transurethral needle ablation of the prostate, microwave thermotherapy, neuromodulation, and, most recently, extracorporeal shockwave therapy have been utilized with varying degrees of benefit.
Transcription (injection) of botulinum toxin
3) Confidence 0.54 Published 2010 Journal Curr Urol Rep Section Abstract Doc Link 20449695 Disease Relevance 0.34 Pain Relevance 0.16
CA1 pyramidal cell spine density and length decreased after transection of Schaffer collaterals and after application of AMPA receptor antagonists or botulinum toxin to unlesioned cultures.
Transcription (transection) of botulinum toxin in spine associated with antagonist and pyramidal cell
4) Confidence 0.02 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10195179 Disease Relevance 0 Pain Relevance 0.46

General Comments

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