INT81213

Context Info Confidence 0.35 First Reported 1999 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 8 Disease Relevance 0.72 Pain Relevance 3.87

Anatomy Link Frequency retina 1 chromaffin cells 1 Gpm6a (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 331 100.00 analgesia 6 98.88 Neuropeptide 10 93.28 Pyramidal cell 6 91.88 Hippocampus 23 91.80 antagonist 8 88.04 agonist 3 87.40 Opioid 1 84.68 tolerance 2 83.28 mu opioid receptor 1 79.48

Disease Link Frequency Relevance Heat Neurodegenerative Disease 4 98.44 Ganglion Cysts 26 90.96 Targeted Disruption 4 89.36 Autism 50 64.72 Cognitive Disorder 1 56.20 Neuroblastoma 8 48.00 INFLAMMATION 2 12.48 Retroviridae Infections 6 5.00 Infection 6 5.00 Intellectual Impairment 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

M6a protein is targeted to the neuron processes of the murine retina

M6a Binding (targeted) of in retina

1) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.09 Pain Relevance 0.03

Taken together, these results suggested a minor trend of increased proliferation associated with M6a but demonstrated that M6a does not regulate retinal cell proliferation significantly.

M6a Binding (associated) of

2) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0 Pain Relevance 0

This implies that the translated M6a protein is targeted to processes distal to the somata.

M6a Binding (targeted) of

3) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2529470 Disease Relevance 0.07 Pain Relevance 0.05

Lack of crosstolerance towards M6G after 1 day of morphine pretreatment was observed, whereas crosstolerance to M6G was observed after 7 days of exposure to morphine pretreatment.

M6G Binding (crosstolerance) of associated with morphine

4) Confidence 0.32 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10837862 Disease Relevance 0 Pain Relevance 1.13

The distal breakpoint in our subject interrupts the Glycoprotein M6A gene GPM6A.

GPM6A Binding (interrupts) of

5) Confidence 0.30 Published 2004 Journal BMC Med Genet Section Body Doc Link PMC411038 Disease Relevance 0.42 Pain Relevance 0.30

Heroin, 6-acetylmorphine and M6G still elicited analgesia in the exon-1 MOR-1 mutant, which also showed specific M6G binding, whereas M6G and 6-acetylmorphine were inactive in the exon-2 MOR-1 mutant.

M6G Binding (binding) of associated with analgesia

6) Confidence 0.11 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10195199 Disease Relevance 0.09 Pain Relevance 0.79

We recently reported the presence of M6G in the matrix of bovine adrenal chromaffin secretory granules, as well as in the material secreted from chromaffin cells [15].

M6G Binding (presence) of in chromaffin cells

7) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0.05 Pain Relevance 0.81

Anti-morphine antibodies were also tested by ELISA in order to determine cross reactivity with morphine, M6G, and M3G, showing a specificity for morphine M6G and M3G.

M6G Binding (specificity) of associated with morphine

8) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265639 Disease Relevance 0 Pain Relevance 0.76

General Comments

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