INT8122

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Context Info
Confidence 0.60
First Reported 1986
Last Reported 2010
Negated 8
Speculated 12
Reported most in Abstract
Documents 39
Total Number 52
Disease Relevance 8.96
Pain Relevance 24.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
brain 10
outflow 2
hippocampus 2
nerve 2
synapse 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 152 100.00 Very High Very High Very High
fluoxetine 114 100.00 Very High Very High Very High
antagonist 111 100.00 Very High Very High Very High
sSRI 71 100.00 Very High Very High Very High
Sumatriptan 58 100.00 Very High Very High Very High
Serotonin 42 100.00 Very High Very High Very High
noradrenaline 26 100.00 Very High Very High Very High
Dopamine 16 100.00 Very High Very High Very High
Pain 16 100.00 Very High Very High Very High
Analgesic 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 70 100.00 Very High Very High Very High
Cognitive Disorder 9 100.00 Very High Very High Very High
Stress 9 100.00 Very High Very High Very High
Nociception 7 99.00 Very High Very High Very High
Brain Injury 6 98.96 Very High Very High Very High
Body Weight 3 98.92 Very High Very High Very High
Pain 11 98.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 98.44 Very High Very High Very High
Hypothermia 3 98.28 Very High Very High Very High
Headache 18 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that the regulation of postsynaptic 5-HT1A receptors is dependent on the levels of 5-HT in the synapse.
Regulation (regulation) of 5-HT1A in synapse
1) Confidence 0.60 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14604841 Disease Relevance 0.33 Pain Relevance 0.48
Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats.
Regulation (Role) of 5-HT1A associated with tramadol, eae, narcan, neuropathic pain, opioid receptor, injury, serotonin and antiallodynic
2) Confidence 0.60 Published 2007 Journal Psychopharmacology (Berl.) Section Title Doc Link 17393145 Disease Relevance 0.19 Pain Relevance 1.08
In radioligand binding experiments, urgosedin had significant binding affinities on alpha1/alpha2, 5-HT1A, 5-HT1B and 5-HT2A receptors.
Regulation (affinities) of 5-HT1A
3) Confidence 0.60 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475835 Disease Relevance 0.52 Pain Relevance 0.21
Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.
Regulation (Effects) of 5-HT1A in brain associated with fluoxetine
4) Confidence 0.60 Published 2004 Journal J. Neurosci. Methods Section Title Doc Link 15589343 Disease Relevance 0.14 Pain Relevance 0.61
By contrast, neither 5-HT1A nor 5-HT1B receptors were significantly affected in any brain region studied.
Neg (neither) Regulation (affected) of 5-HT1A in brain
5) Confidence 0.60 Published 1991 Journal Encephale Section Abstract Doc Link 1666997 Disease Relevance 0 Pain Relevance 0.52
The results suggest different participation of 5-HT1A-, 5-HT2- and 5-HT3-receptors in the mechanisms of memory process and its modulation by the serotonin level in the cerebral serotonergic synapses.
Regulation (participation) of 5-HT1A in synapses associated with serotonin
6) Confidence 0.60 Published 1994 Journal Acta Physiol Pharmacol Bulg Section Abstract Doc Link 7645408 Disease Relevance 0 Pain Relevance 0.70
Modulation of 5-HT1A receptor mediated response by fluoxetine in rat brain.
Regulation (Modulation) of 5-HT1A in brain associated with fluoxetine
7) Confidence 0.44 Published 2000 Journal J Neural Transm Section Title Doc Link 10821446 Disease Relevance 0 Pain Relevance 0.45
OBJECTIVE: This study examined the effects of chronic administration of fluoxetine, a selective serotonin reuptake inhibitor, on cognitive performance and 5-HT1A receptor immunoreactivity following traumatic brain injury.
Spec (examined) Regulation (effects) of 5-HT1A in brain associated with cognitive disorder, ssri, brain injury and fluoxetine
8) Confidence 0.44 Published 2002 Journal Am J Phys Med Rehabil Section Abstract Doc Link 11964577 Disease Relevance 0.35 Pain Relevance 0.23
The observed significant decrease in 5-HT1 sites with concomitant increase in 5-HT stimulated AC activity, after fluoxetine treatment, suggests that fluoxetine, which has high affinity for these sites, acts by modulating the 5-HT1A receptor mediated response in brain.
Regulation (modulating) of 5-HT1A in brain associated with fluoxetine
9) Confidence 0.44 Published 2000 Journal J Neural Transm Section Abstract Doc Link 10821446 Disease Relevance 0 Pain Relevance 0.55
Injured groups showed significantly higher 5-HT1A receptor immunoreactivity on postinjury day 15 than sham-injured rats, and fluoxetine treatment did not alter 5-HT1A receptor immunoreactivity.
Neg (not) Regulation (alter) of 5-HT1A
10) Confidence 0.44 Published 2002 Journal Am J Phys Med Rehabil Section Body Doc Link 11964577 Disease Relevance 0.15 Pain Relevance 0
Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats.
Regulation (Effects) of 5-HT1A in brain associated with cognitive disorder, brain injury and fluoxetine
11) Confidence 0.44 Published 2002 Journal Am J Phys Med Rehabil Section Title Doc Link 11964577 Disease Relevance 0.20 Pain Relevance 0.24
Dimerization of sumatriptan increased the binding affinity for h 5-HT1B (pKi: 9.22 vs. 7.79 for sumatriptan), h 5-HT1D (9.07 vs. 8.08) and also h 5-HT1A receptors (7.80 vs. 6.40), while the binding affinity for h 5-ht1E (6.67 vs. 6.19) and h 5-ht1F (7.37 vs. 7.78) receptors was not affected.
Regulation (affinity) of 5-HT1A associated with sumatriptan
12) Confidence 0.44 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10101238 Disease Relevance 0 Pain Relevance 0.68
The effects of the repeated administration of milnacipran, a serotonin (5-HT)-noradrenaline reuptake inhibitor (SNRI), on the functional status of somatodendritic 5-HT1A receptors, and postsynaptic 5-HT1A receptors were explored using electrophysiological approaches in rats.
Regulation (effects) of 5-HT1A associated with noradrenaline, snri and serotonin
13) Confidence 0.44 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12236634 Disease Relevance 0 Pain Relevance 0.27
The effects of the repeated administration of milnacipran, a serotonin (5-HT)-noradrenaline reuptake inhibitor (SNRI), on the functional status of somatodendritic 5-HT1A receptors, and postsynaptic 5-HT1A receptors were explored using electrophysiological approaches in rats.
Regulation (effects) of 5-HT1A associated with noradrenaline, snri and serotonin
14) Confidence 0.44 Published 2002 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 12236634 Disease Relevance 0 Pain Relevance 0.27
The aim of the present study was to investigate effects of a 5-HT1A antagonist (WAY 100635), 5-HT1B antagonists (SB 216641 and GR 127935) or pindolol, given in combination with paroxetine or fluoxetine (SSRIs), in the forced swimming test in rats (Porsolt test).
Spec (investigate) Regulation (effects) of 5-HT1A associated with antagonist, ssri and fluoxetine
15) Confidence 0.44 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866716 Disease Relevance 0.09 Pain Relevance 0.70
The postsynaptic 5-HT receptor(s) responsible for this inhibition of pyramidal neuron firing remains to be characterized, but it is likely that the 5-HT1A type contributes, at least partially, to its expression.
Spec (partially) Regulation (contributes) of 5-HT1A in pyramidal neuron associated with pyramidal cell
16) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.26
Serotonin (5-HT) receptor antagonism did not contribute to propranolol's action since the 5-HT1A receptor antagonist, (S)-WAY 100135 (P = 0.2), and the 5-HT1B/1D receptor antagonist, GR127935 (P = 0.6), did not affect L-glutamate-evoked neuronal firing.
Neg (not) Regulation (affect) of 5-HT1A in neuronal associated with glutamate, antagonist and serotonin
17) Confidence 0.44 Published 2005 Journal Brain Section Abstract Doc Link 15574468 Disease Relevance 0.20 Pain Relevance 1.07
The results suggest that 5-HT1A and the 5-HT2A receptors are involved in the regulation of acetylcholine release in the spinal cord.
Regulation (involved) of 5-HT1A in spinal cord associated with spinal cord
18) Confidence 0.44 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15733547 Disease Relevance 0 Pain Relevance 0.32
The present study examined the effectiveness of a 5-HT1A/1B/1D receptor agonist, sumatriptan, on pain relief in patients with trigeminal neuralgia.
Spec (examined) Regulation (effectiveness) of 5-HT1A associated with pain, sumatriptan, trigeminal neuralgia and agonist
19) Confidence 0.44 Published 2006 Journal Clin J Pain Section Abstract Doc Link 16988562 Disease Relevance 0.81 Pain Relevance 0.99
Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat.
Regulation (Effect) of 5HT1A associated with agonist
20) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15194447 Disease Relevance 0.30 Pain Relevance 0.34

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