INT81220

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.03
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 10
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 99.98 Very High Very High Very High
Angina 10 97.76 Very High Very High Very High
aspirin 30 88.88 High High
agonist 6 86.16 High High
ischemia 3 81.28 Quite High
Inflammation 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 10 97.76 Very High Very High Very High
Acute Coronary Syndrome 9 96.36 Very High Very High Very High
Myocardial Infarction 14 94.80 High High
Stress 6 94.64 High High
Death 5 85.20 High High
Cv Unclassified Under Development 3 81.28 Quite High
Cardiovascular Disease 4 79.68 Quite High
Thrombosis Related Under Development 1 54.72 Quite High
Adhesions 45 53.36 Quite High
Diabetes Mellitus 32 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glycoprotein (GP) IIb/IIIa inhibitors block the final common pathway of platelet aggregation by preventing fibrinogen from binding to the GP IIb/IIIa platelet receptor.
Negative_regulation (preventing) of platelet Binding (binding) of in platelet
1) Confidence 0.42 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947917 Disease Relevance 0.92 Pain Relevance 0.38
Glycoprotein (GP) IIb/IIIa receptor antagonists inhibit the binding of ligands to activated platelet GP IIb/IIIa receptors and, therefore, prevent the formation of platelet thrombi.
Negative_regulation (inhibit) of platelet Binding (binding) of in platelet associated with antagonist
2) Confidence 0.42 Published 2007 Journal Expert Opin Pharmacother Section Abstract Doc Link 17516878 Disease Relevance 0.05 Pain Relevance 0.05
A monoclonal antibody, AJvW-2, directed against the A1 domain of human vWF specifically blocks the interaction between plasma vWF and platelet glycoprotein (GP) Ib.
Negative_regulation (blocks) of platelet Binding (interaction) of in platelet
3) Confidence 0.41 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 0.92 Pain Relevance 0.20
Among these drugs picotamide attracted the attention of researchers for its ability to inhibit both TxA2 platelet synthase and platelet TxA2 receptors and, in turn, platelet aggregation.
Negative_regulation (inhibit) of platelet Binding (receptors) of in platelet
4) Confidence 0.41 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.08 Pain Relevance 0.20
All modified p8 peptides showed reduced platelet binding. p8-A534 (cf III-30c) lost all binding, while p8-A546 (cf III-30b) retained best binding.
Negative_regulation (reduced) of platelet Binding (binding) of in platelet
5) Confidence 0.41 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.05 Pain Relevance 0

General Comments

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