INT81223

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.09
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VWF) cell adhesion (VWF) endoplasmic reticulum (VWF)
proteinaceous extracellular matrix (VWF)
Anatomy Link Frequency
platelets 6
VWF (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.96 Very High Very High Very High
Angina 5 74.80 Quite High
cva 1 55.60 Quite High
Inflammation 2 38.80 Quite Low
aspirin 5 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 25 98.64 Very High Very High Very High
Acute Coronary Syndrome 5 96.36 Very High Very High Very High
Stress 2 94.64 High High
Myelodysplastic Syndromes 19 92.72 High High
Thrombosis 30 88.08 High High
Hypothermia 1 75.04 Quite High
Cv General 3 Under Development 5 74.80 Quite High
Myocardial Infarction 17 71.36 Quite High
Embolism 2 55.36 Quite High
Adhesions 1 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A monoclonal antibody, AJvW-2, directed against the A1 domain of human vWF specifically blocks the interaction between plasma vWF and platelet glycoprotein (GP) Ib.
Negative_regulation (blocks) of vWF Binding (interaction) of in platelet
1) Confidence 0.42 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10195912 Disease Relevance 0.87 Pain Relevance 0.20
Hereby, abciximab inhibits the final common pathway for platelet aggregation by preventing the binding of fibrinogen and von Willebrand factor to activated platelets [22].
Negative_regulation (preventing) of von Willebrand factor Binding (binding) of in platelets
2) Confidence 0.11 Published 2009 Journal Trials Section Body Doc Link PMC2765937 Disease Relevance 0.29 Pain Relevance 0
Heparin increases the sensitivity of platelets to soluble agonists, inhibits binding to von Willebrand factor, and modestly increases template bleeding times.
Negative_regulation (inhibits) of von Willebrand factor Binding (binding) of in platelets associated with agonist and hemorrhage
3) Confidence 0.02 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2246126 Disease Relevance 0.93 Pain Relevance 0.08

General Comments

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