INT81224

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Context Info
Confidence 0.29
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.28
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ado)
Anatomy Link Frequency
aorta 1
Ado (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 29 100.00 Very High Very High Very High
agonist 2 98.52 Very High Very High Very High
Analgesic 4 93.92 High High
Inflammation 9 93.16 High High
Neurotransmitter 3 78.84 Quite High
ischemia 1 66.40 Quite High
Pain 5 65.60 Quite High
Potency 1 41.92 Quite Low
antagonist 2 25.00 Low Low
Opioid 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Patent Ductus Arteriosus 49 99.08 Very High Very High Very High
Nociception 4 98.08 Very High Very High Very High
Injury 5 96.28 Very High Very High Very High
INFLAMMATION 7 93.16 High High
Stress 1 70.00 Quite High
Epilepsy 2 67.20 Quite High
Cv Unclassified Under Development 1 66.40 Quite High
Pain 4 65.60 Quite High
Hemolysis 16 47.04 Quite Low
Disease 1 33.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During the last 10 years, specific inhibitors of AK based on the endogenous purine nucleoside substrate, ADO, have been developed.
Negative_regulation (inhibitors) of ADO associated with adenocard
1) Confidence 0.29 Published 1998 Journal Curr. Pharm. Des. Section Abstract Doc Link 10197052 Disease Relevance 0.50 Pain Relevance 0.78
Although the ADO may feasibly be deployed in infants with large PDA, the retention skirt may, in some cases, induce a narrowing of the aorta.
Negative_regulation (deployed) of ADO in aorta associated with patent ductus arteriosus
2) Confidence 0.16 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693642 Disease Relevance 0.42 Pain Relevance 0
Inhibition of the ADO-metabolizing enzyme, adenosine kinase (AK) increases extracellular ADO concentrations at sites of tissue trauma and AK inhibitors may have therapeutic potential as analgesic and anti-inflammatory agents.
Negative_regulation (Inhibition) of ADO-metabolizing associated with adenocard, inflammation, analgesic and injury
3) Confidence 0.00 Published 2002 Journal Pain Section Abstract Doc Link 11932067 Disease Relevance 0.36 Pain Relevance 0.68

General Comments

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