INT81226

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Context Info
Confidence 0.64
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 9.28
Pain Relevance 4.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adk) nucleus (Adk) kinase activity (Adk)
Anatomy Link Frequency
neurons 1
synaptic vesicles 1
Adk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 380 100.00 Very High Very High Very High
hyperexcitability 2 100.00 Very High Very High Very High
Antinociceptive 6 99.96 Very High Very High Very High
Inflammation 48 98.88 Very High Very High Very High
Pain 15 98.20 Very High Very High Very High
corticosteroid 5 98.08 Very High Very High Very High
anticonvulsant 1 96.92 Very High Very High Very High
Neurotransmitter 3 94.68 High High
agonist 21 85.68 High High
Glutamate receptor 6 83.80 Quite High
Disease Link Frequency Relevance Heat
Acanthamoeba Keratitis 200 100.00 Very High Very High Very High
Meningoencephalitis 145 99.38 Very High Very High Very High
INFLAMMATION 47 98.88 Very High Very High Very High
Pain 14 98.20 Very High Very High Very High
Infection 160 95.36 Very High Very High Very High
Abscess 10 94.64 High High
Injury 25 93.76 High High
Keloid Scars 5 91.68 High High
Ulcers 20 90.76 High High
Cyst 25 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of adenosine kinase (AK) enhance extracellular concentrations of the inhibitory neuromodulator adenosine (ADO) at sites of tissue hyperexcitability and produce antinociceptive effects in animal models of pain and inflammation.
Gene_expression (produce) of AK associated with pain, adenocard, inflammation, antinociceptive and hyperexcitability
1) Confidence 0.64 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151032 Disease Relevance 0.42 Pain Relevance 0.84
Inhibitors of adenosine kinase (AK) enhance extracellular concentrations of the inhibitory neuromodulator adenosine (ADO) at sites of tissue hyperexcitability and produce antinociceptive effects in animal models of pain and inflammation.
Gene_expression (produce) of adenosine kinase associated with pain, adenocard, inflammation, antinociceptive and hyperexcitability
2) Confidence 0.64 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12151032 Disease Relevance 0.42 Pain Relevance 0.84
Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.
Gene_expression (Synthesis) of Adenosine kinase associated with antinociceptive
3) Confidence 0.59 Published 2005 Journal J. Med. Chem. Section Title Doc Link 16302820 Disease Relevance 0.08 Pain Relevance 0.26
In group C, all the animals were infected, which showed that intrastromal injection of Acanthamoeba was the most effective way to produce AK animal models.
Gene_expression (produce) of AK associated with acanthamoeba keratitis and meningoencephalitis
4) Confidence 0.58 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799973 Disease Relevance 1.17 Pain Relevance 0
Clinical evaluation of AK models
Gene_expression (models) of AK associated with acanthamoeba keratitis
5) Confidence 0.50 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799973 Disease Relevance 1.05 Pain Relevance 0.03
Pathology of AK in the animal models
Gene_expression (Pathology) of AK associated with acanthamoeba keratitis
6) Confidence 0.50 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799973 Disease Relevance 1.84 Pain Relevance 0.22
In previous studies, pigs, rabbits, and Chinese hamsters have been used to produce AK.12-15 Rats and mice are the most widely used animals, since they are easy and cheap to keep in large numbers and there are rich resources of molecular reagents such as antibodies for these animals.
Gene_expression (produce) of AK associated with acanthamoeba keratitis
7) Confidence 0.50 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799973 Disease Relevance 1.91 Pain Relevance 0
The methods to produce AK models were evaluated clinically, histologically, and statistically for 10 days after inoculation.
Gene_expression (produce) of AK associated with acanthamoeba keratitis
8) Confidence 0.45 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799973 Disease Relevance 1.54 Pain Relevance 0.17
The synthesis and SAR of a novel series of non-nucleoside pyridopyrimidine inhibitors of the enzyme adenosine kinase (AK) are described.
Gene_expression (synthesis) of AK associated with adenocard
9) Confidence 0.41 Published 2001 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 11140740 Disease Relevance 0 Pain Relevance 0.26
Structurally novel nucleoside and non-nucleoside AK inhibitors that demonstrate high specificity for the AK enzyme compared with other ADO metabolic enzymes, transporters, and receptors have recently been synthesized.
Gene_expression (synthesized) of AK associated with adenocard
10) Confidence 0.09 Published 2001 Journal CNS Drug Rev Section Abstract Doc Link 11830758 Disease Relevance 0.61 Pain Relevance 0.67
Inhibition of AK produces marked increases in extracellular ADO levels that are localized to cells and tissues undergoing accelerated ADO release.
Gene_expression (produces) of AK associated with adenocard
11) Confidence 0.07 Published 1998 Journal Curr. Pharm. Des. Section Abstract Doc Link 10197052 Disease Relevance 0.25 Pain Relevance 0.58
This implies the loading of adenosine into synaptic vesicles –perhaps hard to achieve if cytoplasmic adenosine levels are very low, which can be the case for cells in which adenosine kinase is strongly expressed.
Gene_expression (expressed) of adenosine kinase in synaptic vesicles associated with adenocard
12) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701281 Disease Relevance 0 Pain Relevance 0.47
However a recent report suggests that adenosine kinase is largely absent from hippocampal neurons of adult rat supporting the plausibility of vesicular loading [57].
Neg (absent) Gene_expression (absent) of adenosine kinase in neurons associated with adenocard
13) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701281 Disease Relevance 0 Pain Relevance 0.47

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