INT81229

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.07
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
stellate ganglion 1
synovial fluid 1
tendon 1
urine 1
joint 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 73 100.00 Very High Very High Very High
reflex sympathetic dystrophy 47 100.00 Very High Very High Very High
alcohol 1 99.16 Very High Very High Very High
Spontaneous pain 1 96.76 Very High Very High Very High
Hyperalgesia 2 96.04 Very High Very High Very High
ketamine 6 95.60 Very High Very High Very High
Arthritis 39 90.24 High High
Rsd 10 85.92 High High
Intractable pain 3 75.00 Quite High
anticonvulsant 2 73.68 Quite High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 86 100.00 Very High Very High Very High
Alpha-1-antitrypsin Deficiency 5 100.00 Very High Very High Very High
Pain 68 99.98 Very High Very High Very High
Arthralgia 5 99.98 Very High Very High Very High
Neuropathic Pain 5 99.76 Very High Very High Very High
Osteogenesis Imperfecta 22 99.56 Very High Very High Very High
Dentinogenesis Imperfecta 25 99.44 Very High Very High Very High
Chromosome Aberrations 3 99.08 Very High Very High Very High
Ganglion Cysts 22 98.78 Very High Very High Very High
Rupture 6 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Molecular studies have demonstrated that most cases result from mutations affecting the genes responsible for the formation of type 1 collagen.
type 1 collagen Binding (formation) of
1) Confidence 0.35 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 17223585 Disease Relevance 0.81 Pain Relevance 0.08
In this study, a comparison was made between three sets of diagnostic criteria (the IASP, Bruehl et al. and Veldman et al.) based on patient reports and physicians' assessments of signs and symptoms associated with CRPS I, in 372 outpatients suspected of having CRPS I.
CRPS I Binding (associated) of associated with complex regional pain syndromes
2) Confidence 0.31 Published 2007 Journal Eur J Pain Section Abstract Doc Link 17400490 Disease Relevance 0.96 Pain Relevance 0.14
To date, the molecular mechanisms by which the described COL1A1 Sp1 diallelic polymorphism associates with bone mass are currently unclear.
COL1A1 Binding (associates) of
3) Confidence 0.29 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.20 Pain Relevance 0
As shown in TablesĀ 6 and 7, the 17-peptide biomarkers were found to be degradation products of eight different proteins: alpha1 antitrypsin (A1AT, two peptides having overlapping sequences), collagen type I alpha 1 (COL1A1; five peptides and three of them having overlapping sequences), collagen type I alpha 2 (COL1A2; one peptide), collagen type III alpha 1 (COL3A1; one peptide), collagen type IX alpha 2 (COL9A2; one peptide), fibrinogen alpha (FGA; two peptides having overlapping sequences), fibrinogen beta (FGB; two peptides having overlapping sequences), and uromodulin (UMOD; three peptides having overlapping sequences).
collagen type I alpha 1 Binding (found) of associated with alpha-1-antitrypsin deficiency
4) Confidence 0.27 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.78 Pain Relevance 0.12
This is the first report of joint pain associated with a COL1A1 mutation and DGI.
COL1A1 Binding (associated) of in joint associated with pain, arthralgia and dentinogenesis imperfecta
5) Confidence 0.23 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11286811 Disease Relevance 1.39 Pain Relevance 0.20
Novel COL1A1 mutation (G559C) [correction of G599C] associated with mild osteogenesis imperfecta and dentinogenesis imperfecta.
COL1A1 Binding (associated) of associated with osteogenesis imperfecta and dentinogenesis imperfecta
6) Confidence 0.23 Published 2001 Journal Arch. Oral Biol. Section Title Doc Link 11286811 Disease Relevance 1.10 Pain Relevance 0
Both between-patient and within-patient coefficients of variation varied for markers in different body fluid compartments, with the lowest variability for serum keratan sulfate, followed by urine type I collagen N-telopeptide crosslinks, and the highest for synovial fluid markers.
urine type I collagen Binding (crosslinks) of in synovial fluid
7) Confidence 0.18 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 10197170 Disease Relevance 0.12 Pain Relevance 0
Type I collagen N-telopeptide cross-links in urine were determined by ELISA.
Type I Binding (cross-links) of in urine
8) Confidence 0.16 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 10197170 Disease Relevance 0.16 Pain Relevance 0
Therefore, an ideal scaffold should support the formation of collagen I, the main component of the tendon, which is responsible for tensile strength [37,48,49].
collagen I Binding (formation) of in tendon
9) Confidence 0.16 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0 Pain Relevance 0
However, the interaction between collagen I and biglycan is not yet completely understood [57].
collagen I Binding (interaction) of
10) Confidence 0.15 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2837661 Disease Relevance 0.07 Pain Relevance 0
Together with the specific ring and der(22) chromosomes associated with COL1A1 and PDGFB, additional chromosomal abnormalities have been described in DFSP.
COL1A1 Binding (associated) of associated with chromosome aberrations
11) Confidence 0.14 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.44 Pain Relevance 0
All other tested variants were not associated with CRPS I.
CRPS I Binding (associated) of
12) Confidence 0.13 Published 2010 Journal Clin J Pain Section Body Doc Link 20173430 Disease Relevance 0.14 Pain Relevance 0
The clinical presentation of CRPS I in children is, to some extent, different from adults and therefore sometimes not recognized early.
CRPS I Binding (recognized) of associated with complex regional pain syndromes
13) Confidence 0.10 Published 2008 Journal Acta Paediatr. Section Abstract Doc Link 18410465 Disease Relevance 0.72 Pain Relevance 0.26
Achilles tendinopathy (n=85), Achilles rupture (n=41) and asymptomatic control (n=125) participants were genotyped for the COL1A1 Sp1-binding site polymorphism.
COL1A1 Binding (binding) of associated with rupture and tendinopathy
14) Confidence 0.08 Published 2009 Journal J Sci Med Sport Section Abstract Doc Link 18353721 Disease Relevance 0.68 Pain Relevance 0.08
Moreover, the intensity of staining for collagen type II was greater than collagen type I in sections of pellets grown in the presence of 2.5 ?
collagen type I Binding (greater) of
15) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
The formation of collagen type I and collagen type II was confirmed by immunochemical staining of histological sections.
collagen type I Binding (formation) of
16) Confidence 0.06 Published 2008 Journal The Open Biomedical Engineering Journal Section Body Doc Link PMC2701073 Disease Relevance 0 Pain Relevance 0.05
The most widely used markers are urinary N-terminal crosslinked type 1 collagen telopeptide (ntx) and C-terminal cross-linked type 1 telopeptide.
type 1 collagen telopeptide Binding (crosslinked) of
17) Confidence 0.06 Published 2008 Journal Current Oncology Section Body Doc Link PMC2216426 Disease Relevance 0.52 Pain Relevance 0.17
BSAP proved to be the most predictive and while serum N-terminal propeptide of type 1 collagen (PINP) and serum C-terminal crosslinked telopeptide of type 1 collagen (CTx) were associated with a reduction in spine fractures, they only showed similar, but nonsignificant, associations with hip and non-spine fractures.
type 1 collagen Binding (crosslinked) of in hip
18) Confidence 0.05 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936260 Disease Relevance 0.17 Pain Relevance 0
This intervention is not more effective than placebo in reducing complaints for CRPS I patients and provides no addition to already-established interventions for CRPS I.
CRPS I Neg (no) Binding (interventions) of associated with complex regional pain syndromes
19) Confidence 0.05 Published 2008 Journal J Pain Section Abstract Doc Link 18403271 Disease Relevance 0.66 Pain Relevance 0.16
PURPOSE: The complex regional pain syndrome type I (CRPS I) is a painful neuropathic disorder with an antecedent disproportionate trauma leading to spontaneous pain, hyperalgesia, impaired motor function, swelling, changes in sweating and vascular abnormalities without nerve injury.
CRPS I Binding (complex) of in nerve associated with complex regional pain syndromes, pain, pressure and volume under development, neuropathic pain, hyperalgesia, nervous system injury, reflex sympathetic dystrophy, congenital anomalies, spontaneous pain and injury
20) Confidence 0.05 Published 2010 Journal Handchir Mikrochir Plast Chir Section Abstract Doc Link 20205066 Disease Relevance 1.03 Pain Relevance 0.39

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