INT81231

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Context Info
Confidence 0.74
First Reported 1999
Last Reported 2007
Negated 2
Speculated 1
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 9.38
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (LGALS3) extracellular region (LGALS3) mRNA processing (LGALS3)
proteinaceous extracellular matrix (LGALS3) plasma membrane (LGALS3) nucleus (LGALS3)
Anatomy Link Frequency
osteoblasts 3
joints 2
articular 2
bladder 2
chondrocytes 1
LGALS3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 720 99.84 Very High Very High Very High
Inflammation 352 98.60 Very High Very High Very High
metalloproteinase 386 98.44 Very High Very High Very High
endometriosis 336 93.12 High High
cytokine 102 78.60 Quite High
isoflurane 24 67.52 Quite High
interstitial cystitis 3 63.44 Quite High
Pain 56 23.88 Low Low
Inflammatory response 2 21.04 Low Low
substance P 42 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 792 99.84 Very High Very High Very High
Endometriosis 448 99.84 Very High Very High Very High
Osteoporosis 144 99.84 Very High Very High Very High
INFLAMMATION 304 98.60 Very High Very High Very High
Pressure And Volume Under Development 264 97.36 Very High Very High Very High
Apoptosis 34 93.04 High High
Hyperplasia 24 90.64 High High
Targeted Disruption 24 89.48 High High
Autoimmune Disease 2 86.92 High High
Necrosis 28 80.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our recent work reported the capacity of normal and OA human chondrocytes to synthesize gal-3, with an increased expression level in human OA articular cartilage [29].
Gene_expression (synthesize) of gal-3 in articular cartilage associated with osteoarthritis
1) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.71 Pain Relevance 0.25
Results obtained by Ohshima and colleagues [15] demonstrated that intra-articular production of gal-3 could occur in joints even during OA, and particularly during inflammatory phases.
Gene_expression (production) of gal-3 in joints associated with inflammation and osteoarthritis
2) Confidence 0.74 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.58 Pain Relevance 0.22
Further studies were then performed using human osteoarthritic (OA) chondrocytes and subchondral bone osteoblasts, in which the effect of gal-3 (0 to 10 ?
Gene_expression (effect) of gal-3 in osteoblasts associated with osteoarthritis
3) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.41 Pain Relevance 0
Effects of galectin-3 on osteoblastic markers in human OA subchondral bone osteoblasts
Gene_expression (Effects) of galectin-3 in osteoblasts associated with osteoporosis and osteoarthritis
4) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.42 Pain Relevance 0.28
Recombinant human gal-3 (rh-gal-3) was prepared in our laboratory and sterilized on a 0.2 ?
Gene_expression (prepared) of gal-3
5) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.30 Pain Relevance 0.15
This result was confirmed by the fact that gal-3 alone and gal-3 in the presence of KT5823 did not produce results with a significant difference.
Neg (not) Gene_expression (produce) of gal-3
6) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Intra-articular injection of galectin-3 in mice
Gene_expression (injection) of galectin-3 in articular
7) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.34 Pain Relevance 0.13
Recombinant human gal-3 (rh-gal-3) was prepared in our laboratory and sterilized on a 0.2 ?
Gene_expression (human) of gal-3
8) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.30 Pain Relevance 0.15
Recombinant human gal-3 (rh-gal-3) was prepared in our laboratory and sterilized on a 0.2 ?
Gene_expression (Recombinant) of gal-3
9) Confidence 0.64 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.31 Pain Relevance 0.15
This indicates that gal-3 could be found extracellularly in the joint.
Gene_expression (found) of gal-3 in joint
10) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 1.00 Pain Relevance 0.35
As Ohshima and colleagues [15] showed that gal-3 was markedly present in OA synovial tissues during the inflammatory phase and could be recovered in the synovial fluid, we explored the potential extracellular role of gal-3.
Gene_expression (present) of gal-3 in synovial fluid associated with inflammation and osteoarthritis
11) Confidence 0.57 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.55 Pain Relevance 0.22
The combination of gal-3 with either KT5720 or KT5823 also significantly inhibited osteocalcin production compared to their respective controls (p < 0.008 and p < 0.01, respectively), indicating that neither protein kinase A nor protein kinase G are involved in gal-3-inhibited osteocalcin production.
Gene_expression (production) of gal-3-inhibited
12) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
This result was confirmed by the fact that gal-3 alone and gal-3 in the presence of KT5823 did not produce results with a significant difference.
Neg (not) Gene_expression (produce) of gal-3
13) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
To this end, we first examined its in vivo effect in mice having received an intra-articular injection of gal-3, and further investigated its effect on cells from two OA articular tissues: cartilage and subchondral bone.


Gene_expression (injection) of gal-3 in articular associated with osteoarthritis
14) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.47 Pain Relevance 0.19
This result indicates that Erk1/Erk2 kinases are also involved to some extent in gal-3 signalling transduction.
Gene_expression (transduction) of gal-3
15) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
Recombinant human gal-3 (rh-gal-3) was prepared in our laboratory and sterilized on a 0.2 ?
Gene_expression (prepared) of rh-gal-3
16) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.30 Pain Relevance 0.15
In contrast, PD98059 prevented further inhibition of osteocalcin production by gal-3.
Gene_expression (production) of gal-3
17) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0 Pain Relevance 0
However, not all MMPs were stimulated by gal-3 in chondrocytes, since collagenase-3 (MMP-13) was unaffected (data not shown).
Gene_expression (stimulated) of gal-3 in chondrocytes associated with metalloproteinase
18) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.33 Pain Relevance 0.23
Signalling pathways regulating osteocalcin were analyzed in the presence of gal-3.
Spec (analyzed) Gene_expression (presence) of gal-3
19) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.44 Pain Relevance 0.04
Moreover, gal-3 injection generated lesions that affected both cartilage and subchondral bone tissue.
Gene_expression (injection) of gal-3 in cartilage
20) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.50 Pain Relevance 0.23

General Comments

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