INT81247

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Context Info
Confidence 0.31
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.06
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Tnnt2) protein binding, bridging (Tnnt2) cytoplasm (Tnnt2)
Anatomy Link Frequency
arterioles 3
pyramidal neurons 1
neurons 1
NG108-15 1
LTS 1
Tnnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 15 100.00 Very High Very High Very High
Pyramidal cell 48 99.72 Very High Very High Very High
isoflurane 8 99.60 Very High Very High Very High
Hyperalgesia 9 95.36 Very High Very High Very High
anesthesia 6 95.28 Very High Very High Very High
Spinal cord 1 93.12 High High
Action potential 34 88.60 High High
Inflammation 2 76.64 Quite High
Angina 1 75.44 Quite High
spinal dorsal horn 1 75.40 Quite High
Disease Link Frequency Relevance Heat
Nociception 7 98.40 Very High Very High Very High
Myocardial Infarction 7 96.48 Very High Very High Very High
Decapitation 5 95.96 Very High Very High Very High
Hyperalgesia 10 95.36 Very High Very High Very High
INFLAMMATION 2 64.24 Quite High
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Coronary Heart Disease 1 5.00 Very Low Very Low Very Low
Hypertrophic Cardiomyopathy 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both cases cTnT phosphorylation, expressed as a percentage for 2D-gels or normalized for cMyBP-C protein content in each sample derived from Sypro Ruby stained 1D-gels, did not vary between groups.
Gene_expression (expressed) of cTnT
1) Confidence 0.31 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0
We observed expression of voltage-operated calcium (Ca(V)) channels Ca(V)3.1 (T-type), Ca(V)3.2 (T-type), and Ca(V)1.2 (L-type) in cremaster arterioles (n = 3 rats).
Gene_expression (expression) of T-type in arterioles
2) Confidence 0.27 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12388244 Disease Relevance 0.10 Pain Relevance 0.23
These data suggest that T-type calcium channels are expressed and involved in maintenance of myogenic tone in rat cremaster muscle arterioles.
Gene_expression (expressed) of T-type in arterioles associated with calcium channel
3) Confidence 0.27 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12388244 Disease Relevance 0.05 Pain Relevance 0.17
We observed expression of voltage-operated calcium (Ca(V)) channels Ca(V)3.1 (T-type), Ca(V)3.2 (T-type), and Ca(V)1.2 (L-type) in cremaster arterioles (n = 3 rats).
Spec (observed) Gene_expression (expression) of T-type in arterioles
4) Confidence 0.27 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12388244 Disease Relevance 0.10 Pain Relevance 0.23
Our findings thus establish that spinal and peripheral NaHS/H2S activates or sensitizes Cav3.2 T-type Ca2+ channels expressed in the primary afferents and/or spinal nociceptive neurons, leading to sensitization of nociceptive processing and hyperalgesia.
Gene_expression (expressed) of T-type Ca2 in neurons associated with nociception and hyperalgesia
5) Confidence 0.11 Published 2009 Journal Pain Section Abstract Doc Link 19167819 Disease Relevance 0.79 Pain Relevance 0.51
Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively.
Gene_expression (Specificities) of cTnT
6) Confidence 0.09 Published 2010 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 20551280 Disease Relevance 0.40 Pain Relevance 0.08
In voltage-clamp experiments on the T-type Ca2+ current, which produces the LTS, IFL decreased the spatial distribution of imposed voltages and hence impaired the activation of spatially distant T channels.
Gene_expression (produces) of T-type Ca2 in LTS associated with isoflurane
7) Confidence 0.06 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10200213 Disease Relevance 0 Pain Relevance 0.56
In the patch-clamp study using undifferentiated NG108-15 cells that express T-type, but not other types, of Ca(2+) channels, NaHS enhanced the currents through the T-type channels, an effect being blocked by DTNB.
Neg (not) Gene_expression (express) of T-type in NG108-15
8) Confidence 0.02 Published 2007 Journal Pain Section Abstract Doc Link 17346888 Disease Relevance 0.62 Pain Relevance 0.44
To confirm that T-type channels are not expressed in L5 pyramidal neurons, current-clamp experiments were carried out in the whole-cell configuration.
Neg (not) Gene_expression (expressed) of T-type in pyramidal neurons associated with pyramidal cell
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659773 Disease Relevance 0 Pain Relevance 0.05
This suggests that T-type channels are not expressed by these neurons, at least not in the soma membrane nor the membrane near it.
Neg (not) Gene_expression (expressed) of T-type in soma
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659773 Disease Relevance 0 Pain Relevance 0.11

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