INT81249

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 8.13
Pain Relevance 12.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
dorsal root ganglia 3
nociceptors 2
nerve 1
spinal cord 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 137 100.00 Very High Very High Very High
agonist 54 100.00 Very High Very High Very High
Osm-9-like TRP channel 2 2 100.00 Very High Very High Very High
Nerve growth factor 3 99.98 Very High Very High Very High
Pain 40 99.92 Very High Very High Very High
medulla 4 99.78 Very High Very High Very High
vanilloid receptor subtype 1 5 99.70 Very High Very High Very High
Spinal cord 10 99.50 Very High Very High Very High
Peripheral sensitization 3 99.36 Very High Very High Very High
dorsal root ganglion 30 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 32 99.92 Very High Very High Very High
Ganglion Cysts 112 99.24 Very High Very High Very High
INFLAMMATION 24 99.20 Very High Very High Very High
Hyperalgesia 15 98.48 Very High Very High Very High
Nervous System Injury 5 98.48 Very High Very High Very High
Injury 5 98.04 Very High Very High Very High
Nociception 7 97.72 Very High Very High Very High
Glioma 2 97.36 Very High Very High Very High
Hypersensitivity 4 96.44 Very High Very High Very High
Fever 3 95.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to VR1, VRL-1 is activated at a higher temperature threshold and it does not respond to capsaicin or protons.
Positive_regulation (activated) of VRL-1 associated with qutenza
1) Confidence 0.70 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.33 Pain Relevance 0.22
These results suggest that TRPV2 upregulation contributes to peripheral sensitization during inflammation and is responsible for pain hypersensitivity to noxious high temperature stimuli.
Positive_regulation (upregulation) of TRPV2 associated with inflammation, hypersensitivity, stimulus evoked pain, peripheral sensitization and fever
2) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 1.02 Pain Relevance 0.63
Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors.
Positive_regulation (activated) of VRL-1 in nociceptors associated with vanilloid receptor subtype 1, qutenza, nociceptor and osm-9-like trp channel 2
3) Confidence 0.69 Published 2004 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 15174761 Disease Relevance 0.29 Pain Relevance 0.70
Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors.
Positive_regulation (activated) of vanilloid receptor-like protein 1 in nociceptors associated with vanilloid receptor subtype 1, qutenza, nociceptor and osm-9-like trp channel 2
4) Confidence 0.69 Published 2004 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 15174761 Disease Relevance 0.29 Pain Relevance 0.70
Noxious heat may act as an endogenous activator of the ionotropic capsaicin receptor (VR1) and of its recently found homologue VRL1, expressed in rat dorsal root ganglion cells and present along their nerve fibres.
Positive_regulation (activator) of VRL1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and qutenza
5) Confidence 0.64 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11703449 Disease Relevance 0.10 Pain Relevance 0.47
Upregulation of TRPV2, P2X(3), and ASIC3 may play important roles in the mechanical hyperalgesia induced by cisplatin.
Positive_regulation (Upregulation) of TRPV2 associated with hyperalgesia
6) Confidence 0.62 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.87 Pain Relevance 0.98
Here, we show that probenecid is able to activate TRPV2 using electrophysiological and calcium imaging techniques with TRPV2-expressing HEK293T cells.
Positive_regulation (activate) of TRPV2 associated with imagery
7) Confidence 0.55 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17850966 Disease Relevance 0.08 Pain Relevance 0.32
Our results show that peripheral axotomy did not regulate TRPV2 in the DRG, spinal cord, or brainstem; however, TRPV2 was up-regulated in sympathetic postganglionic neurons following injury, suggesting a potential role for TRPV2 in sympathetically mediated neuropathic pain.
Positive_regulation (up-regulated) of TRPV2 in DRG associated with medulla, dorsal root ganglion, injury, neuropathic pain and spinal cord
8) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.77 Pain Relevance 0.78
Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1.
Neg (not) Positive_regulation (increased) of TRPV2 in nerve associated with nerve growth factor
9) Confidence 0.50 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.75 Pain Relevance 0.61
A similar distribution of TRPV2 was observed after inflammation.
Positive_regulation (distribution) of TRPV2 associated with inflammation
10) Confidence 0.47 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.74 Pain Relevance 0.59
We demonstrate that self-sensitization of heat-evoked currents through TRPV2 does not require extracellular calcium and that TRPV2 can be activated in cell-free membrane patches in the outside-out configuration.
Positive_regulation (activated) of TRPV2
11) Confidence 0.47 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17596195 Disease Relevance 0.15 Pain Relevance 0.27
Five other sensory thermoTRPs-TRPV1, TRPV3, TRPV4, TRPM8 and TRPA1-failed to show a response to this drug in the same heterologous expression system, suggesting that probenecid is a specific activator for TRPV2.
Positive_regulation (activator) of TRPV2
12) Confidence 0.46 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17850966 Disease Relevance 0.21 Pain Relevance 0.37
Pretreatment with citral did not prevent TRPV2 activation by 2-aminoethyldiphenyl borate (Fig. 1E), but inhibited the channels once they entered their active (conducting) state.
Positive_regulation (activation) of TRPV2
13) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.10
These results suggest that TRPV2 is specifically activated by probenecid and that this chemical might be useful for investigation of pain-related TRPV2 function.
Positive_regulation (activated) of TRPV2 associated with pain
14) Confidence 0.42 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17850966 Disease Relevance 0.34 Pain Relevance 0.36
Citral significantly increased TRPV1, TRPV3, TRPM8, and TRPA1 (Fig. 1A and B) currents, but not TRPV2 (Fig. 1E), TRPV4, or background currents in nontransfected cells (data not shown).
Neg (not) Positive_regulation (increased) of TRPV2
15) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0.14 Pain Relevance 0.41
Instead, VRL-1 is activated by high temperatures, with a threshold of approximately 52 degrees C.
Positive_regulation (activated) of VRL-1
16) Confidence 0.23 Published 1999 Journal Nature Section Abstract Doc Link 10201375 Disease Relevance 0.15 Pain Relevance 0.59
Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury.
Positive_regulation (Increased) of TRPV2 in dorsal root ganglia associated with nervous system injury
17) Confidence 0.19 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17517374 Disease Relevance 0.47 Pain Relevance 0.37
Our results show that peripheral axotomy did not regulate TRPV2 in the DRG, spinal cord, or brainstem; however, TRPV2 was up-regulated in sympathetic postganglionic neurons following injury, suggesting a potential role for TRPV2 in sympathetically mediated neuropathic pain.
Positive_regulation (up-regulated) of TRPV2 in spinal cord associated with medulla, dorsal root ganglion, injury, neuropathic pain and spinal cord
18) Confidence 0.17 Published 2004 Journal Brain Res. Section Abstract Doc Link 15261111 Disease Relevance 0.77 Pain Relevance 0.78
Citral initially increased the agonist-evoked responses of TRPV1, TRPV2, and TRPV3 (Fig. 2A, B).
Positive_regulation (increased) of TRPV2 associated with agonist
19) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.55
The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines.
Positive_regulation (activated) of vanilloid receptor 1-like receptor associated with glioma
20) Confidence 0.11 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15098930 Disease Relevance 0.10 Pain Relevance 0.50

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