INT81250

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.54
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
DRG 1
nociceptors 1
nervous system 1
PBMC 1
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nociceptor 11 99.66 Very High Very High Very High
dorsal root ganglion 3 99.64 Very High Very High Very High
Adelta 1 99.42 Very High Very High Very High
qutenza 46 99.36 Very High Very High Very High
Inflammation 4 92.48 High High
agonist 4 87.76 High High
antagonist 5 78.16 Quite High
vanilloid receptor subtype 1 3 77.72 Quite High
Dopamine 11 75.00 Quite High
Endocannabinoid 1 67.44 Quite High
Disease Link Frequency Relevance Heat
Glioma 3 99.84 Very High Very High Very High
Ganglion Cysts 3 99.64 Very High Very High Very High
Renal Disease 9 97.04 Very High Very High Very High
INFLAMMATION 4 92.48 High High
Death 4 75.00 Quite High
Nociception 1 65.56 Quite High
Pain 1 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.
Transcription (levels) of TRPV2 in DRG associated with dorsal root ganglion and qutenza
1) Confidence 0.64 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.28 Pain Relevance 0.69
We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.
Transcription (distribution) of TRPV2 in nociceptors associated with qutenza, nociceptor and adelta
2) Confidence 0.43 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17287441 Disease Relevance 0 Pain Relevance 0.77
VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat.
Transcription (transcripts) of VRL-1 in nervous system
3) Confidence 0.18 Published 1999 Journal Nature Section Abstract Doc Link 10201375 Disease Relevance 0.13 Pain Relevance 0.51
The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines.
Transcription (expressed) of VRL1 associated with glioma
4) Confidence 0.16 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15098930 Disease Relevance 0.10 Pain Relevance 0.51
The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines.
Transcription (expressed) of vanilloid receptor 1-like receptor associated with glioma
5) Confidence 0.16 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15098930 Disease Relevance 0.10 Pain Relevance 0.51
The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines.
Transcription (detected) of VRL1 associated with glioma
6) Confidence 0.16 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15098930 Disease Relevance 0.10 Pain Relevance 0.58
TRPV1 and TRPV2 mRNA expression in peripheral blood mononuclear cells (PBMC) was similar in controls and ESKD patients by quantitative real-time RT-PCR.
Transcription (expression) of TRPV2 in PBMC associated with renal disease
7) Confidence 0.12 Published 2009 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19619644 Disease Relevance 0.83 Pain Relevance 0.70

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox