INT81251

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2010
Negated 2
Speculated 7
Reported most in Abstract
Documents 78
Total Number 85
Disease Relevance 28.27
Pain Relevance 41.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv2) intracellular (Trpv2) transmembrane transport (Trpv2)
cytoplasm (Trpv2)
Anatomy Link Frequency
neurons 14
dorsal root ganglion 11
spinal cord 4
neuronal 4
nerve 4
Trpv2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 432 100.00 Very High Very High Very High
dorsal root ganglion 157 100.00 Very High Very High Very High
Snapping jaw 18 100.00 Very High Very High Very High
vanilloid receptor subtype 1 17 100.00 Very High Very High Very High
Calcitonin gene-related peptide 13 100.00 Very High Very High Very High
Root ganglion neuron 287 99.98 Very High Very High Very High
nociceptor 105 99.98 Very High Very High Very High
Pain 85 99.94 Very High Very High Very High
Inflammation 103 99.92 Very High Very High Very High
Hyperalgesia 28 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 463 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 18 100.00 Very High Very High Very High
INFLAMMATION 74 99.92 Very High Very High Very High
Hyperalgesia 43 99.88 Very High Very High Very High
Nervous System Injury 7 98.92 Very High Very High Very High
Nociception 38 98.76 Very High Very High Very High
Pain 74 98.64 Very High Very High Very High
Glioma 2 98.00 Very High Very High Very High
Neuropathic Pain 41 97.24 Very High Very High Very High
Renal Disease 9 96.94 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the expression of VRL1 by A- or C-fiber sensory neurons in rats was investigated by using a VRL1 and 200 kDa neurofilament (NF200, an A-fiber marker) double immunohistochemical staining method.
Spec (investigated) Gene_expression (expression) of VRL1 in sensory neurons associated with c fibre
1) Confidence 0.78 Published 2001 Journal Neuroreport Section Abstract Doc Link 11726776 Disease Relevance 0.07 Pain Relevance 0.53
Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons.
Gene_expression (expressed) of VRL1 in sensory neurons associated with c fibre and qutenza
2) Confidence 0.78 Published 2001 Journal Neuroreport Section Title Doc Link 11726776 Disease Relevance 0.07 Pain Relevance 0.88
These results suggest that both C-fiber and Adelta-fiber primary sensory neurons express VRL1, and VRL1 may play an important role in nociception.
Gene_expression (express) of VRL1 in primary sensory neurons associated with nociception, c fibre and adelta
3) Confidence 0.78 Published 2001 Journal Neuroreport Section Abstract Doc Link 11726776 Disease Relevance 0.19 Pain Relevance 0.60
The F-11 parental cell line N18TG2 also expressed murine VRL-1.
Gene_expression (expressed) of VRL-1 in N18TG2
4) Confidence 0.78 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.35 Pain Relevance 0.22
Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression.
Gene_expression (expression) of VRL-1 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
5) Confidence 0.78 Published 2003 Journal Eur. J. Biochem. Section Title Doc Link 14622291 Disease Relevance 0.27 Pain Relevance 0.17
Here we describe the expression of VRL-1 in the rat dorsal root ganglion-derived cell line F-11, a hybridoma of mouse neuroblastoma (N18TG2) and rat dorsal root ganglion cells.
Gene_expression (expression) of VRL-1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and neuroblastoma
6) Confidence 0.78 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.37 Pain Relevance 0.23
Immunofluorescence analysis of the endogenous VRL-1 in F-11 cells gives only weak signals in the cytoplasm whereas the overexpressed rat VRL-1 appears mainly at the plasma membrane.
Gene_expression (overexpressed) of VRL-1 in plasma
7) Confidence 0.78 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.27 Pain Relevance 0.16
We found by RT-PCR that F-11 cells express not only the rat VRL-1, but also its mouse orthologue in a single cell.
Gene_expression (express) of VRL-1
8) Confidence 0.78 Published 2003 Journal Eur. J. Biochem. Section Abstract Doc Link 14622291 Disease Relevance 0.36 Pain Relevance 0.22
Consistent with previous reports, we found that VRL-1 and VR1 are expressed in different dorsal root ganglion (DRG) cell bodies.
Gene_expression (expressed) of VRL-1 in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
9) Confidence 0.78 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.36 Pain Relevance 0.67
This is consistent with the expression of VRL-1 by myelinated nociceptors that target laminae I and IIi and in nonnociceptive Abeta fibers that target laminae III/IV.
Gene_expression (expression) of VRL-1 in nociceptors associated with nociceptor and abeta
10) Confidence 0.78 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.39 Pain Relevance 0.91
Unlike VR1, however, VRL-1 is primarily expressed by medium- and large-diameter primary afferents, which suggests that nociceptive processing is but one of the functions to which VRL-1 contributes.
Gene_expression (expressed) of VRL-1 associated with nociception
11) Confidence 0.78 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.20 Pain Relevance 0.39
Almost all VRL-1-expressing cells labeled for N52 (a marker of myelinated afferents), consistent with VRL-1 expression in Adelta and Abeta fibers.
Gene_expression (expression) of VRL-1 associated with adelta and abeta
12) Confidence 0.78 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.41 Pain Relevance 0.76
Dorsal rhizotomy reduced, but did not eliminate, the immunostaining in all dorsal horn laminae, which indicates that VRL-1 expression derives from both DRG cells and from neurons intrinsic to the brain or spinal cord.
Gene_expression (expression) of VRL-1 in spinal cord associated with dorsal root ganglion, dorsal rhizotomy, dorsal horn and spinal cord
13) Confidence 0.78 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14961565 Disease Relevance 0.37 Pain Relevance 0.86
Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG.
Gene_expression (expression) of TRPV2 associated with inflammation
14) Confidence 0.78 Published 2005 Journal Pain Section Title Doc Link 16298071 Disease Relevance 0.69 Pain Relevance 0.88
Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1.
Gene_expression (expression) of TRPV2 in nerve associated with nerve growth factor
15) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.75 Pain Relevance 0.61
TRPV2 expression is concentrated in a subset of medium-sized dorsal root ganglion neurons, independent of transient receptor potential vanilloid subfamily member 1 (TRPV1) expression.
Gene_expression (expression) of TRPV2 in neurons associated with ganglion cysts and root ganglion neuron
16) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.66 Pain Relevance 0.45
To analyze the contribution of TRPV2 to the development of inflammation-induced hyperalgesia, the expression of TRPV2 in primary sensory neurons was analyzed after intraplantar injection of complete Freund's adjuvant (CFA).
Spec (analyzed) Gene_expression (expression) of TRPV2 in primary sensory neurons associated with hyperalgesia and inflammation
17) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.50 Pain Relevance 0.33
Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1.
Gene_expression (expression) of TRPV2 in nerve associated with nerve growth factor
18) Confidence 0.78 Published 2005 Journal Pain Section Abstract Doc Link 16298071 Disease Relevance 0.75 Pain Relevance 0.62
However, although TRPV2 is expressed in a distinct population of thinly myelinated primary afferents, a widespread expression in a variety of neuronal and non-neuronal tissues suggests a more diverse physiological role of TRPV2.
Gene_expression (expressed) of TRPV2 in neuronal
19) Confidence 0.78 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17596195 Disease Relevance 0.22 Pain Relevance 0.13
In the present study, we demonstrate that the features of heterologously expressed rat TRPV2 closely resemble those of high-threshold heat-evoked currents in medium- and large-sized capsaicin-insensitive rat dorsal root ganglion (DRG) neurons.
Gene_expression (expressed) of TRPV2 in neurons associated with ganglion cysts, dorsal root ganglion and qutenza
20) Confidence 0.78 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17596195 Disease Relevance 0.25 Pain Relevance 0.22

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