INT81264

Context Info Confidence 0.58 First Reported 1999 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 13 Total Number 16 Disease Relevance 9.82 Pain Relevance 9.53

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf)

Anatomy Link Frequency nerve 14 blood 2 primary sensory neurons 2 respiratory tract 2 keratinocytes 2 Ngf (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 115 100.00 Serotonin 16 100.00 chemokine 11 100.00 Inflammation 189 99.90 substance P 91 99.38 unmyelinated 9 99.16 dorsal root ganglion 55 99.12 bradykinin 6 98.62 Pain 183 98.52 Kinase C 15 98.16

Disease Link Frequency Relevance Heat Cancer 78 100.00 Melanoma 51 100.00 Respiratory Syncytial Virus 27 99.98 INFLAMMATION 187 99.90 Death 70 99.76 Targeted Disruption 54 99.70 Neuroblastoma 2 99.52 Ganglion Cysts 66 99.12 Pain 190 98.52 Nociception 67 98.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results of these studies indicated that substance P and neurokinin A can directly induce nerve growth factor mRNA expression and the secretion of bioactive nerve growth factor protein in both human and murine keratinocytes.

Positive_regulation (induce) of Localization (secretion) of nerve growth factor in keratinocytes associated with nerve growth factor and substance p

1) Confidence 0.58 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710915 Disease Relevance 0 Pain Relevance 0.94

Neutralization of nerve growth factor induces plasticity of ATP-sensitive P2X3 receptors of nociceptive trigeminal ganglion neurons.

Positive_regulation (induces) of Localization (Neutralization) of nerve growth factor in nerve associated with ganglion cysts, nociception, nerve growth factor and trigeminal ganglion neurons

2) Confidence 0.50 Published 2007 Journal J. Neurosci. Section Title Doc Link 17670966 Disease Relevance 0.65 Pain Relevance 0.69

In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?

Spec (find) Positive_regulation (find) of Localization (application) of NGF in microglia

3) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.63

The secretion of glia cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and transforming growth factor-beta (TGF-beta) contributes to the maintenance of epithelial integrity and the secretion of endothelins might be involved in vasoregulation.

Positive_regulation (contributes) of Spec (might) Localization (secretion) of NGF in nerve associated with nerve growth factor

4) Confidence 0.46 Published 2006 Journal Z Gastroenterol Section Abstract Doc Link 16981072 Disease Relevance 0.26 Pain Relevance 0.17

Therefore, it is reasonable to propose that NGF secreted by melanoma tumor was transferred through blood and bound to its cognate receptors in the salivary gland, ultimately resulting in the stimulation of multiple TFs expression including Egr-1 (Fig. 6).

Positive_regulation (transferred) of Localization (secreted) of NGF in blood associated with nerve growth factor, cancer and melanoma

5) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 1.32 Pain Relevance 0.40

Prior studies showed that DRG explants from Runx3-knockout mouse embryos extended short neurites in the presence of NT3, a ligand for TrkC, but not in the presence of NGF, a ligand for TrkA [16].

Neg (not) Positive_regulation (extended) of Localization (presence) of NGF in neurites associated with targeted disruption and dorsal root ganglion

6) Confidence 0.41 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.89 Pain Relevance 0.36

Inflammation can lead to an enhanced production and release of NGF.

Positive_regulation (lead) of Localization (release) of NGF associated with nerve growth factor and inflammation

7) Confidence 0.28 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.34 Pain Relevance 0.81

Inflammation can lead to an enhanced production and release of NGF.

Positive_regulation (enhanced) of Localization (release) of NGF associated with nerve growth factor and inflammation

8) Confidence 0.28 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877069 Disease Relevance 0.34 Pain Relevance 0.81

RSV-induced release of NGF may lead to short- and long-term changes in the distribution and reactivity of sensory nerves across the respiratory tract, thus participating in exaggerated inflammatory reactions during and after the infection.

Positive_regulation (induced) of Localization (release) of NGF in respiratory tract associated with inflammation, nerve growth factor, infection and respiratory syncytial virus

9) Confidence 0.22 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440791 Disease Relevance 0.88 Pain Relevance 0.62

The experimental model was the mouse PC12 neuroblastoma cell line which can be induced to differentiate into neurons in the presence of NGF (nerve growth factor).

Positive_regulation (induced) of Localization (presence) of nerve growth factor in nerve associated with neuroblastoma and nerve growth factor

10) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.24 Pain Relevance 0.08

The experimental model was the mouse PC12 neuroblastoma cell line which can be induced to differentiate into neurons in the presence of NGF (nerve growth factor).

Positive_regulation (induced) of Localization (presence) of NGF in nerve associated with neuroblastoma and nerve growth factor

11) Confidence 0.17 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.24 Pain Relevance 0.08

Pro-inflammatory agents such as nerve growth factor (NGF), ATP, bradykinins, serotonin, histamine, proteases and chemokines lead to TRPV1 sensitization through phospholipase C activation.

Positive_regulation (activation) of Localization (sensitization) of NGF in nerve associated with chemokine, nerve growth factor, inflammation and serotonin

12) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.63 Pain Relevance 0.97

Pro-inflammatory agents such as nerve growth factor (NGF), ATP, bradykinins, serotonin, histamine, proteases and chemokines lead to TRPV1 sensitization through phospholipase C activation.

Positive_regulation (activation) of Localization (sensitization) of nerve growth factor in nerve associated with chemokine, nerve growth factor, inflammation and serotonin

13) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.64 Pain Relevance 0.97

After local tissue injury, the release of chemical mediators such as potassium ions, ATP, bradykinin and prostaglandin E2 directly activate nerve endings and indirectly trigger the release of algesic mediators such as histamine, 5-hydroxytryptamine and nerve growth factor from other cells, which, in turn, stimulate proximal afferent nerve endings and silent nociceptors.

Positive_regulation (trigger) of Localization (release) of nerve growth factor in nerve associated with nerve growth factor, nociceptor, injury and bradykinin

14) Confidence 0.12 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202208 Disease Relevance 0.78 Pain Relevance 0.90

The relevance of trophic support, mainly NGF and IGF-1, and other growth factor signaling through trk receptors and activation of PI3K/Akt and PKC, is also linked to the key role played by GSK-3?

Positive_regulation (through) of Localization (relevance) of NGF associated with kinase c

15) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.15 Pain Relevance 0.08

An increase in TRPV1 expression occurs in primary sensory neurons after peripheral inflammation and requires retrograde transport of nerve growth factor (NGF).

Positive_regulation (requires) of Localization (transport) of nerve growth factor in primary sensory neurons associated with nerve growth factor and inflammation

16) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 1.00 Pain Relevance 1.02

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