INT81289

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2011
Negated 11
Speculated 0
Reported most in Body
Documents 192
Total Number 192
Disease Relevance 104.50
Pain Relevance 33.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
brains 18
monocytes 16
macrophages 9
lung 8
epithelial cells 8
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2209 100.00 Very High Very High Very High
chemokine 388 100.00 Very High Very High Very High
agonist 362 100.00 Very High Very High Very High
antagonist 224 100.00 Very High Very High Very High
Inflammation 3686 99.98 Very High Very High Very High
ischemia 368 99.98 Very High Very High Very High
Hippocampus 257 99.88 Very High Very High Very High
Eae 51 99.82 Very High Very High Very High
rheumatoid arthritis 367 99.80 Very High Very High Very High
lumbar region 2 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 2126 100.00 Very High Very High Very High
Burns 1443 100.00 Very High Very High Very High
Disease 1347 100.00 Very High Very High Very High
Hemophilus Infection 534 100.00 Very High Very High Very High
Targeted Disruption 324 100.00 Very High Very High Very High
Fever 41 100.00 Very High Very High Very High
Cv General 2 Under Development 36 100.00 Very High Very High Very High
INFLAMMATION 4194 99.98 Very High Very High Very High
Cv Unclassified Under Development 313 99.98 Very High Very High Very High
Arthritis 287 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, our results show that commensal microflora in intestinal tract induce TLR4 expression of intestinal epithelial cells and enhance the bacterial killing activity of inflammatory cells in burn.
Positive_regulation (induce) of Gene_expression (expression) of TLR4 in epithelial cells associated with inflammation and burns
1) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 0.66 Pain Relevance 0.08
LPS supplement significantly increased TLR4 mRNA expression of intestinal mucosa compared with that of antibiotics + burn group.


Positive_regulation (increased) of Gene_expression (expression) of TLR4 mRNA associated with burns
2) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.25 Pain Relevance 0
LPS supplement stimulates the TLR4 expression of intestinal mucosa and significantly decreases thermal injury-induced bacterial translocation.
Positive_regulation (stimulates) of Gene_expression (expression) of TLR4 associated with injury
3) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.01 Pain Relevance 0
Oral TLR4 ligand supplement after burn increased TLR4 mRNA expression of intestinal mucosa
Positive_regulation (increased) of Gene_expression (expression) of TLR4 mRNA associated with burns
4) Confidence 0.69 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.24 Pain Relevance 0
In agreement with the concept of an increase in local TLR4 expression, immunostaining demonstrated the localization of TLR4 in infiltrating macrophages in ruptured plaque material occluding the culprit coronary artery.
Positive_regulation (increase) of Gene_expression (expression) of TLR4 in macrophages
5) Confidence 0.67 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.92 Pain Relevance 0.03
The results of the present study indicate an increase in monocytic TLR4 expression not only in the systemic circulation, but also at the site of plaque rupture.
Positive_regulation (increase) of Gene_expression (expression) of TLR4 in plaque associated with rupture
6) Confidence 0.67 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.53 Pain Relevance 0.06
Based on findings of enhanced TLR-4 expression in mice fed WD, we hypothesized that PA augments the response to bacterial toxins (lipopolysaccharide; LPS).
Positive_regulation (enhanced) of Gene_expression (expression) of TLR-4
7) Confidence 0.67 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.41 Pain Relevance 0.24
Interestingly, mechanical ventilation is reported to increase expression of TLR4 and its associated co-adapter, CD14 [39,40,45,46].
Positive_regulation (increase) of Gene_expression (expression) of TLR4
8) Confidence 0.62 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0.40 Pain Relevance 0.13
Since lipopolysaccharide (LPS) or endotoxin is a specific ligand for TLR4, and because TLR4 expression is increased on human monocytes in healthy volunteers undergoing LPS challenge [18], and in patients with sepsis [19, 20], particular attention has been made to this receptor and signalling pathway.
Positive_regulation (increased) of Gene_expression (expression) of TLR4 in monocytes associated with sepsis
9) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.39 Pain Relevance 0.08
Intracellular mechanism of action could include inhibition of protein geranylgeranylation and farnesylation leading to the hypothesis that proteins of the Ras family and the phosphoinositide 3-kinase/protein kinase Akt-pathway are of importance in mediating the TLR4 expression [73].
Positive_regulation (mediating) of Gene_expression (expression) of TLR4
10) Confidence 0.60 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.27 Pain Relevance 0.06
Indeed, real time PCR analysis detected a CCI-induced upregulation of Tlr4 and Il1b expression in the lumbar region of wt but not Cckbr KO mice.
Positive_regulation (upregulation) of Gene_expression (expression) of Tlr4 in lumbar region associated with eae and lumbar region
11) Confidence 0.50 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18054398 Disease Relevance 0.70 Pain Relevance 0.66
increased in the cerebrum of TLR4w AD mice compared to TLR4w non-AD mice (P = 0.029, 0.013, 0.031 and 0.001, respectively) (Fig. 7).
Positive_regulation (increased) of Gene_expression (non) of TLR4w in cerebrum associated with disease
12) Confidence 0.50 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2430555 Disease Relevance 0.99 Pain Relevance 0.65
Oral TLR4 ligand supplement after burn increased TLR4 mRNA expression of intestinal mucosa
Positive_regulation (burn) of Gene_expression (expression) of TLR4 mRNA associated with burns
13) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.24 Pain Relevance 0
A larger increase in the TLR4 expression was induced in the washed DEP + LPS group than in the LPS group (Fig. 1).


Positive_regulation (increase) of Gene_expression (expression) of TLR4
14) Confidence 0.49 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127221 Disease Relevance 0.30 Pain Relevance 0.07
Our data supports that ischemia stimulates cytokine expression via TLR4-independent mechanisms (such as mechanical stretch), resulting in similar myocardial levels of TNF and IL-1?
Positive_regulation (stimulates) of Gene_expression (expression) of TLR4 associated with ischemia and cytokine
15) Confidence 0.49 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.65 Pain Relevance 0.50
It is also found out that the expression level of TLR4 has a positive correlation with serum levels of TNF-?
Positive_regulation (level) of Gene_expression (expression) of TLR4
16) Confidence 0.48 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.67 Pain Relevance 0.50
The fold changes in TLR2 and TLR4 levels with HSP70 stimulation were higher in patients with AMI (both local and systemic samples) compared with patients with SA and controls (Figure 4).
Positive_regulation (stimulation) of Gene_expression (levels) of TLR4
17) Confidence 0.48 Published 2008 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2552974 Disease Relevance 0.08 Pain Relevance 0
Targeted destruction of Kupffer cells with clodronate liposomes blunted histological evidence of steatohepatitis and prevented increases in TLR4 expression, induced increases in the production of TNF-?
Positive_regulation (increases) of Gene_expression (expression) of TLR4 in Kupffer cells
18) Confidence 0.48 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.33 Pain Relevance 0.11
In a methionine choline deficiency (MCD) diet-induced model of steatohepatitis, histological evidence of liver inflammation, portal endotoxemia and enhanced TLR-4 expression occurs in wild-type mice fed the MCD diet.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR-4 in liver associated with choline deficiency, endotoxemia and inflammation
19) Confidence 0.48 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2939438 Disease Relevance 1.42 Pain Relevance 0.11
As expected, PA enhanced chemokine (IL-8) expression, TLR-4 mRNA levels and the static adhesion of monocytes to C3A hepatocytes.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR-4 mRNA in hepatocytes associated with chemokine and adhesions
20) Confidence 0.48 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2984476 Disease Relevance 0.71 Pain Relevance 0.30

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