INT81291

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 8.78
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
glial cells 2
femoral artery 2
DRG 2
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 4 99.76 Very High Very High Very High
ischemia 55 98.00 Very High Very High Very High
Inflammatory response 28 97.56 Very High Very High Very High
Inflammation 208 96.92 Very High Very High Very High
cytokine 81 91.96 High High
Inflammatory mediators 8 90.08 High High
Calcitonin gene-related peptide 10 89.52 High High
fibrosis 88 86.80 High High
cINOD 2 81.44 Quite High
antagonist 2 77.20 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 257 100.00 Very High Very High Very High
Hypertension 144 99.08 Very High Very High Very High
Stress 90 98.60 Very High Very High Very High
Cv Unclassified Under Development 38 98.00 Very High Very High Very High
Pressure Volume 2 Under Development 24 97.40 Very High Very High Very High
INFLAMMATION 245 97.20 Very High Very High Very High
Injury 62 95.64 Very High Very High Very High
Fibrosis 108 93.80 High High
Apoptosis 237 93.60 High High
Renal Disease 28 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings are approximately consistent with previous studies in that up-regulation of HO-1 mRNA expression has been revealed under oxidative stress situation.
Regulation (regulation) of Gene_expression (expression) of HO-1 mRNA associated with stress
1) Confidence 0.60 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.15 Pain Relevance 0
Effect of HO expression on the development of hypertension
Regulation (Effect) of Gene_expression (expression) of HO associated with hypertension
2) Confidence 0.50 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.96 Pain Relevance 0
Pharmacological modulation of heme oxygenase (HO) gene expression may have significant therapeutic potential in oxidant-induced disorders, such as ischemia reperfusion (I/R) injury.
Regulation (modulation) of Gene_expression (expression) of HO associated with ischemia and injury
3) Confidence 0.42 Published 2006 Journal Apoptosis Section Abstract Doc Link 16703264 Disease Relevance 0.63 Pain Relevance 0.16
Pretreatment with Znpp-9 had no effect on HO-1 expression, but capsaicin abrogated the expression of HO-1 induced by MLA in DRG.
Neg (no) Regulation (effect) of Gene_expression (expression) of HO-1 in DRG associated with qutenza
4) Confidence 0.40 Published 2002 Journal Regul. Pept. Section Abstract Doc Link 11738242 Disease Relevance 0 Pain Relevance 0.68
These results suggest that activation of PPARgamma negatively regulate iNOS expression and positively regulates HO-1 expression in glial cells.
Regulation (regulates) of Gene_expression (expression) of HO-1 in glial cells
5) Confidence 0.40 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.16 Pain Relevance 0.16
Of note, exogenous application of CORM-2 had an augmenting effect on the expression levels of HO-1, indicating that the exogenous addition of one of the reaction products of HO-1 has a positive feed forward effect on HO-1 expression.
Regulation (effect) of Gene_expression (expression) of HO-1
6) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.75 Pain Relevance 0.29
Of note, exogenous application of CORM-2 had an augmenting effect on the expression levels of HO-1, indicating that the exogenous addition of one of the reaction products of HO-1 has a positive feed forward effect on HO-1 expression.
Regulation (effect) of Gene_expression (expression) of HO-1
7) Confidence 0.29 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.81 Pain Relevance 0.31
To assess the effect of HO-1 expression on vascular response, we measured PE-induced contraction and ACh-induced relaxation in the femoral artery.
Regulation (effect) of Gene_expression (expression) of HO in femoral artery
8) Confidence 0.25 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.84 Pain Relevance 0
Effect of HO-1 expression on vascular responses to PE and Ach
Regulation (Effect) of Gene_expression (expression) of HO
9) Confidence 0.25 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.80 Pain Relevance 0
In addition, we examined the effect of diabetes on the expression of HO-1 and HO-2 in rat kidneys.
Spec (examined) Regulation (effect) of Gene_expression (expression) of HO associated with diabetes mellitus
10) Confidence 0.25 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.85 Pain Relevance 0
Of note, exogenous application of CORM-2 had an augmenting effect on the expression levels of HO-1, indicating that the exogenous addition of one of the reaction products of HO-1 has a positive feed forward effect on HO-1 expression.
Regulation (effect) of Gene_expression (expression) of HO-1
11) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.81 Pain Relevance 0.31
Therefore, we next assessed whether HO-1 expression was up-regulated by I/Ri and whether CORM-2 treatment had modulatory effects on this stress response.
Spec (whether) Regulation (regulated) of Spec (whether) Gene_expression (expression) of HO-1 associated with stress
12) Confidence 0.21 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.38 Pain Relevance 0.09
Moreover, Hemin did up regulate HO-1 expression while maintained the epithelial phenotype in TGF-?
Regulation (regulate) of Gene_expression (expression) of HO-1
13) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.78 Pain Relevance 0.20
These data corroborate our results and suggest that HO-1 expression is important to attenuate EMT.
Regulation (important) of Gene_expression (expression) of HO-1
14) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001459 Disease Relevance 0.87 Pain Relevance 0.25

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