INT81293

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 53
Total Number 59
Disease Relevance 41.54
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
blood 10
body 6
ventricles 4
plasma 4
glial cells 4
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
Rostral ventrolateral medulla 27 99.84 Very High Very High Very High
qutenza 10 99.70 Very High Very High Very High
ischemia 111 99.12 Very High Very High Very High
Inflammatory mediators 24 98.28 Very High Very High Very High
Inflammatory response 65 98.00 Very High Very High Very High
Inflammation 523 97.88 Very High Very High Very High
anesthesia 34 97.66 Very High Very High Very High
depression 9 97.28 Very High Very High Very High
cINOD 11 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Renal Disease 82 100.00 Very High Very High Very High
Fibrosis 333 99.96 Very High Very High Very High
Diabetes Mellitus 714 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 50 99.80 Very High Very High Very High
Hyperoxia 20 99.70 Very High Very High Very High
Hypertension 412 99.68 Very High Very High Very High
Nicotine Addiction 164 99.60 Very High Very High Very High
Ureteral Obstruction 270 99.50 Very High Very High Very High
Injury 192 99.40 Very High Very High Very High
Cv Unclassified Under Development 91 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates.
Positive_regulation (inducible) of Gene_expression (expression) of HO-1
1) Confidence 0.70 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024540 Disease Relevance 0.48 Pain Relevance 0.18
The results therefore suggest that HO-1 expression increases in both ischemic and pharmacological PC, and HO-1 has cellular protective effect against cell death and apoptosis in ischemia-reperfusion-induced oxidative injury.
Positive_regulation (increases) of Gene_expression (expression) of HO-1 associated with ischemia, injury, apoptosis and death
2) Confidence 0.69 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 1.08 Pain Relevance 0.33
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Positive_regulation (induces) of Gene_expression (expression) of HSP32
3) Confidence 0.69 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.61 Pain Relevance 0.03
In vivo, exogeneous management of HO-1 to rats by means of a recombinant adenovirus expressing HO-1 considerably decreased acute lung injury induced by hyperoxia.20 Similarly, increased expression levels of HO-1 in the bronchiolar epithelium via adenoviral transferred gene, the rats were protected against damage when consequently encountered to hyperoxia.18,27
Positive_regulation (increased) of Gene_expression (expression) of HO in epithelium associated with hyperoxia and adult respiratory distress syndrome
4) Confidence 0.68 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.54 Pain Relevance 0.03
For example, smoking has been proved to increase the expression of HO-1 in airway tissues.29
Positive_regulation (increase) of Gene_expression (expression) of HO associated with nicotine addiction
5) Confidence 0.68 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.25 Pain Relevance 0
Pretreatment with beraprost attenuated AGML and downregulated the expression of HNE and HO-1, while sensory denervation aggravated AGML and upregulated the expression of HNE and HO-1.
Positive_regulation (upregulated) of Gene_expression (expression) of HO-1
6) Confidence 0.64 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.18 Pain Relevance 0.08
Administration of higenamine (bolus, i.p) 1 h prior to I/R-injury significantly decreased the release of cytochrome c, caspase-3 activity, and Bax expression but up-regulated the expression of Bcl-2, HO-1, and HO enzyme activity in the left ventricles, which were inhibited by ZnPP IX, an enzyme inhibitor of HO-1.
Positive_regulation (up-regulated) of Gene_expression (expression) of HO-1 in ventricles associated with injury
7) Confidence 0.64 Published 2006 Journal Apoptosis Section Abstract Doc Link 16703264 Disease Relevance 0.88 Pain Relevance 0.16
Our results demonstrate that basal levels of the constitutively expressed HO-2 are not increased, but O2?
Neg (not) Positive_regulation (increased) of Gene_expression (expressed) of HO
8) Confidence 0.64 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.91 Pain Relevance 0.03
In the present study, overexpression of HO-1 resulted in decreased O2?
Positive_regulation (overexpression) of Gene_expression (overexpression) of HO
9) Confidence 0.64 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.74 Pain Relevance 0.04
However, PPARgamma activator alone induced HO-1 expression and further enhanced LPS/IFN-gamma-induced HO-1 expression.
Positive_regulation (enhanced) of Gene_expression (expression) of HO-1
10) Confidence 0.61 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.17 Pain Relevance 0.17
Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells.
Positive_regulation (increase) of Gene_expression (expression) of heme oxygenase-1 in glial cells
11) Confidence 0.61 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10203248 Disease Relevance 0.18 Pain Relevance 0.18
However, PPARgamma activator alone induced HO-1 expression and further enhanced LPS/IFN-gamma-induced HO-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of HO-1
12) Confidence 0.61 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.17 Pain Relevance 0.18
Immunoneutralization of HIF-1alpha also blunted the preferential increase in HO-1 expression.
Positive_regulation (blunted) of Gene_expression (expression) of HO-1
13) Confidence 0.60 Published 2009 Journal Shock Section Abstract Doc Link 19333137 Disease Relevance 0.79 Pain Relevance 0.46
Bronchoalveolar lavage (BAL) fluid and lung tissue from patients with ARDS revealed increased expression of HO-1.20,31 In addition, ischemia–reperfusion induced lung injury in murine models is a strong stimulator of HO-1, which causes protective effects and this could signify the body’s effort to return oxygenation and blood flow to tissues or to remediate the oxidative damage associated with decreased blood flow.18,32
Positive_regulation (increased) of Gene_expression (expression) of HO in body associated with lung injury, ischemia and adult respiratory distress syndrome
14) Confidence 0.59 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.47 Pain Relevance 0.05
In this situation HO-1 can be overexpressed as a compensatory antioxidant when GSH is depleted and acts as a cytoprotective component against oxidative stress.24,25 Indeed, extensive studies presently support the belief that HO-1 serves to provide effective cytoprotective role in various in vitro and in vivo models of cellular and tissue damage induced by oxidants.26–28
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of HO associated with stress
15) Confidence 0.59 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.67 Pain Relevance 0
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Positive_regulation (induces) of Gene_expression (expression) of HO-1
16) Confidence 0.50 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.61 Pain Relevance 0.03
The main reason for this result is that despite of HO-1, HO-2 is not an inducible isoform and constitutively expressed for the most part of the body.11,16,17
Neg (not) Positive_regulation (inducible) of Gene_expression (expressed) of HO in body
17) Confidence 0.49 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.09 Pain Relevance 0
Subsequent studies have clarified that HO-1 mRNA levels increased in airways of subjects with asthma than in normal cases.
Positive_regulation (increased) of Gene_expression (levels) of HO-1 mRNA associated with asthma
18) Confidence 0.49 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.25 Pain Relevance 0
The main reason for this result is that despite of HO-1, HO-2 is not an inducible isoform and constitutively expressed for the most part of the body.11,16,17
Neg (not) Positive_regulation (inducible) of Gene_expression (expressed) of HO in body
19) Confidence 0.49 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.09 Pain Relevance 0
It has also been reported in the literature that NO production upregulates heme oxygenase (Hmox-1) production [7,8].
Positive_regulation (upregulates) of Neg (NO) Gene_expression (production) of Hmox-1
20) Confidence 0.49 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2258306 Disease Relevance 0.45 Pain Relevance 0

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