INT81294

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.39
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
glial cells 6
endothelial cells 2
Pparg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 99.24 Very High Very High Very High
cINOD 15 99.18 Very High Very High Very High
agonist 3 96.92 Very High Very High Very High
Substantia nigra 2 96.92 Very High Very High Very High
Inflammation 21 93.76 High High
dopaminergic neurodegeneration 6 92.16 High High
COX-2 inhibitor 2 85.52 High High
Inflammatory mediators 2 79.00 Quite High
Inflammatory response 2 78.40 Quite High
Dopamine 4 55.92 Quite High
Disease Link Frequency Relevance Heat
Disease 14 99.32 Very High Very High Very High
INFLAMMATION 28 99.06 Very High Very High Very High
Parkinson's Disease 8 98.88 Very High Very High Very High
Cardiovascular Disease 11 97.04 Very High Very High Very High
Diabetes Mellitus 58 90.32 High High
Stress 6 89.88 High High
Disorder Of Lipid Metabolism 15 87.12 High High
Atherosclerosis 1 83.44 Quite High
Insulin Resistance 27 79.88 Quite High
Metabolic Syndrome 7 61.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of anti-inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo-oxygenase-2 (COX-2) or activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) yields neuroprotection in MPTP-induced PD.
Negative_regulation (inhibition) of Positive_regulation (activation) of PPAR-gamma associated with parkinson's disease, inflammation, cinod and disease
1) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17254027 Disease Relevance 1.35 Pain Relevance 0.54
The PPAR-gamma antagonist GW9662 (2-chloro-5-nitrobenzanilide) prevented the activation of PPAR-gamma by HCT1026.
Negative_regulation (prevented) of Positive_regulation (activation) of PPAR-gamma associated with antagonist
2) Confidence 0.42 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15686492 Disease Relevance 0.26 Pain Relevance 0.57
The use of anti-inflammatory drugs for PD treatment has been proposed, and inhibition of cyclo-oxygenase-2 (COX-2) or activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) yields neuroprotection in MPTP-induced PD.
Negative_regulation (inhibition) of Positive_regulation (activation) of peroxisome proliferator-activated receptor gamma associated with parkinson's disease, inflammation, cinod and disease
3) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17254027 Disease Relevance 1.34 Pain Relevance 0.54
These results suggest that activation of PPARgamma negatively regulate iNOS expression and positively regulates HO-1 expression in glial cells.
Negative_regulation (regulate) of Positive_regulation (activation) of PPARgamma in glial cells
4) Confidence 0.39 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.17 Pain Relevance 0.17
Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells.
Negative_regulation (inhibit) of Positive_regulation (Activators) of PPARgamma in glial cells
5) Confidence 0.39 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10203248 Disease Relevance 0.18 Pain Relevance 0.18
Activators of peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibit inducible nitric oxide synthase expression but increase heme oxygenase-1 expression in rat glial cells.
Negative_regulation (inhibit) of Positive_regulation (Activators) of peroxisome proliferator-activated receptor-gamma in glial cells
6) Confidence 0.39 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10203248 Disease Relevance 0.18 Pain Relevance 0.18
In cultured endothelial cells ligand activation of PPAR gamma has been shown to inhibit thrombin-induced endothelin-1 production (Delerive et al 1999) and plasminogen activator inhibitor type 1 expression (Kato et al 1999).
Negative_regulation (inhibit) of Positive_regulation (activation) of PPAR gamma in endothelial cells
7) Confidence 0.07 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291335 Disease Relevance 0.91 Pain Relevance 0.04

General Comments

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