INT81295

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.87
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng, Nos2) aging (Nos2) peroxisome (Nos2)
intracellular (Nos2) cytoplasm (Nos2) cytosol (Nos2)
Anatomy Link Frequency
glial cells 4
Ifng (Rattus norvegicus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 10 99.64 Very High Very High Very High
Inflammation 4 99.56 Very High Very High Very High
Analgesic 2 99.14 Very High Very High Very High
Paracetamol 9 98.74 Very High Very High Very High
cINOD 4 98.16 Very High Very High Very High
aspirin 3 88.36 High High
Tetrahydrobiopterin 1 84.72 Quite High
agonist 1 54.56 Quite High
Disease Link Frequency Relevance Heat
Glioma 3 100.00 Very High Very High Very High
INFLAMMATION 6 99.56 Very High Very High Very High
Diabetes Mellitus 2 95.08 Very High Very High Very High
Hypertension 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat glial cells, lipopolysaccharide and interferon-gamma (LPS/IFN-gamma) induced expression of both inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1).
interferon-gamma Positive_regulation (induced) of Gene_expression (expression) of iNOS in glial cells
1) Confidence 0.39 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.19 Pain Relevance 0.20
In rat glial cells, lipopolysaccharide and interferon-gamma (LPS/IFN-gamma) induced expression of both inducible nitric oxide synthase (iNOS) and heme oxygenase-1 (HO-1).
interferon-gamma Positive_regulation (induced) of Gene_expression (expression) of inducible nitric oxide synthase in glial cells
2) Confidence 0.34 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10203248 Disease Relevance 0.19 Pain Relevance 0.20
In addition, clonidine (1.0 x 10(-4) M) enhanced NOS-II mRNA expression in rat C6 glioma cells, as induced by Escherichia coli lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma).
IFN-gamma Positive_regulation (enhanced) of Gene_expression (expression) of NOS-II mRNA associated with glioma and clonidine
3) Confidence 0.11 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10874128 Disease Relevance 0.39 Pain Relevance 0.85
These findings suggest that acetaminophen may exert analgesic or anti-inflammatory effect by inhibiting iNOS expression induced by LPS plus IFN-gamma at transcriptional level by suppression of NF-kappaB binding activity, whereas salicylates exert its effect by inhibiting iNOS expression at the translational or posttranslational level.
IFN-gamma Positive_regulation (induced) of Gene_expression (expression) of iNOS associated with paracetamol, inflammation and analgesic
4) Confidence 0.03 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10860828 Disease Relevance 0.10 Pain Relevance 0.81

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