INT81311

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.46
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (FOXC1) nucleus (FOXC1) DNA binding (FOXC1)
transcription factor binding (FOXC1) cytoplasm (FOXC1)
Anatomy Link Frequency
enterocytes 1
FOXC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 204 98.94 Very High Very High Very High
cytokine 240 93.44 High High
amygdala 1 83.68 Quite High
Hippocampus 5 74.96 Quite High
Thalamus 7 72.44 Quite High
spastic colon 1 71.72 Quite High
agonist 72 70.88 Quite High
Inflammatory response 12 58.00 Quite High
anesthesia 3 54.44 Quite High
medulla 1 52.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 210 98.94 Very High Very High Very High
Colitis 7 98.00 Very High Very High Very High
Myopia 2 97.04 Very High Very High Very High
Disease 55 94.48 High High
Inflammatory Bowel Disease 198 88.20 High High
Glaucoma 3 84.52 Quite High
Death 6 81.16 Quite High
Nystagmus 10 79.08 Quite High
Cataract 16 77.68 Quite High
Microphthalmia 7 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously did not find any PITX2 nor FOXC1 mutation in these patients.
Spec (find) Gene_expression (mutation) of FOXC1
1) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2649307 Disease Relevance 0.63 Pain Relevance 0.05
CNS ARA concentrations
Gene_expression (concentrations) of CNS ARA
2) Confidence 0.39 Published 2005 Journal BMC Med Section Body Doc Link PMC1184078 Disease Relevance 0 Pain Relevance 0.14
ARA and AEM were not detected in any individuals studied.
Neg (not) Gene_expression (detected) of ARA
3) Confidence 0.15 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10204612 Disease Relevance 0.82 Pain Relevance 0.07
and GRO), while others were higher expressed after ARA (MCP-1, and angiogenin).
Gene_expression (expressed) of ARA
4) Confidence 0.13 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.71 Pain Relevance 0.25
Because EPA and OA resulted in comparable changes in the proportions of ARA in the phospholipids of the enterocytes, the reported effects may be ascribed to the increased ARA proportion in the ARA cultured cells.
Gene_expression (proportion) of ARA in enterocytes
5) Confidence 0.10 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.63 Pain Relevance 0.12
Therefore, we fully agree that in an in vivo situation pro-inflammatory effects of ARA are probably mediated by eicosanoids synthesized from ARA, however, these effects are not derived from a direct eicosanoid mediated activation of NF-?
Gene_expression (synthesized) of ARA associated with inflammation
6) Confidence 0.10 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.30 Pain Relevance 0.15
B activation and ICAM-1 expression as compared to ARA indeed showed that EPA and ARA differently affected the NF-?
Gene_expression (showed) of ARA
7) Confidence 0.10 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.22 Pain Relevance 0.24
This indicates that the increased basal PGE2 production by ARA cannot explain the different effects of ARA and EPA on NF-?
Gene_expression (production) of ARA
8) Confidence 0.10 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0 Pain Relevance 0.15
Despite these clear differences in non-stimulated and stimulated ICAM-1 expression between ARA and EPA or OA, the net stimulated ICAM-1 expression did not differ between the groups (ANOVA P = 0.134).
Gene_expression (expression) of ARA
9) Confidence 0.09 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.08 Pain Relevance 0

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