INT81326

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 18.50
Pain Relevance 5.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ang) extracellular space (Ang) extracellular region (Ang)
RNA binding (Ang) nucleus (Ang) nuclease activity (Ang)
Anatomy Link Frequency
liver 4
kidney 4
macrophage 2
acinar cells 2
Epithelium 2
Ang (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 105 100.00 Very High Very High Very High
Chronic pancreatitis 60 99.64 Very High Very High Very High
ischemia 22 99.32 Very High Very High Very High
Inflammation 146 97.76 Very High Very High Very High
Inflammatory mediators 2 97.04 Very High Very High Very High
chemokine 12 95.68 Very High Very High Very High
tolerance 1 88.44 High High
fibrosis 6 88.08 High High
metalloproteinase 4 86.08 High High
tetrodotoxin 1 85.12 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 42 100.00 Very High Very High Very High
Cancer 335 99.84 Very High Very High Very High
Metastasis 320 99.78 Very High Very High Very High
Pancreatitis 60 99.64 Very High Very High Very High
Colon Cancer 328 99.56 Very High Very High Very High
Cv Unclassified Under Development 22 99.32 Very High Very High Very High
Renal Disease 24 98.76 Very High Very High Very High
Lymphatic System Cancer 62 98.72 Very High Very High Very High
Aggression 6 98.00 Very High Very High Very High
INFLAMMATION 153 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that ANG expression is increased in pancreatic cancer surrounding tissue but is not increased in pure chronic pancreatitis, and that ANG is potentially involved in the pancreatic cancer microenvironment rather than the establishment of pure chronic pancreatitis.
Positive_regulation (increased) of Gene_expression (expression) of ANG associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.67 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.46 Pain Relevance 0.75
Increased angiogenin expression in obstructive chronic pancreatitis surrounding pancreatic cancer but not in pure chronic pancreatitis.
Positive_regulation (Increased) of Gene_expression (expression) of angiogenin associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.67 Published 1999 Journal Pancreas Section Title Doc Link 10206479 Disease Relevance 1.08 Pain Relevance 0.65
These findings suggest that ANG expression is increased in pancreatic cancer surrounding tissue but is not increased in pure chronic pancreatitis, and that ANG is potentially involved in the pancreatic cancer microenvironment rather than the establishment of pure chronic pancreatitis.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of ANG associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.67 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.47 Pain Relevance 0.76
We previously demonstrated the increased expression of angiogenin (ANG) in pancreatic cancer and its relation to cancer aggressiveness; however, the expression patterns and the roles of angiogenin in chronic pancreatitis are still unknown.
Positive_regulation (increased) of Gene_expression (expression) of ANG associated with cancer, aggression, pancreatic cancer and chronic pancreatitis
4) Confidence 0.67 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 0.83 Pain Relevance 0.46
We previously demonstrated the increased expression of angiogenin (ANG) in pancreatic cancer and its relation to cancer aggressiveness; however, the expression patterns and the roles of angiogenin in chronic pancreatitis are still unknown.
Positive_regulation (increased) of Gene_expression (expression) of angiogenin associated with cancer, aggression, pancreatic cancer and chronic pancreatitis
5) Confidence 0.49 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 0.83 Pain Relevance 0.46
By contrast, acinar cells and interstitial fibroblasts in the tissues surrounding pancreatic cancer showed increased ANG mRNA expression.
Positive_regulation (increased) of Gene_expression (expression) of ANG in acinar cells associated with pancreatic cancer
6) Confidence 0.49 Published 1999 Journal Pancreas Section Abstract Doc Link 10206479 Disease Relevance 1.32 Pain Relevance 0.76
Our data implicates that the proinflammatory properties of Ang-(1–7) and the Mas receptor in the kidney are primarily stimulated by a local activation of the NF-?
Positive_regulation (stimulated) of Gene_expression (receptor) of Ang in kidney
7) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.60 Pain Relevance 0.40
The activation of the renal renin angiotensin system (RAS), characterized by elevated ACE expression and increased local angiotensin (Ang) II production, has been found in many human kidney diseases [3].
Positive_regulation (increased) of Gene_expression (production) of Ang in kidney associated with renal disease
8) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 0.89 Pain Relevance 0.17
The pro-angiogenic effects of ANG II are mediated by the ANG II type 1 receptor (AT1R), which is overexpressed in several human cancers [7-19].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ANG associated with cancer
9) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.23 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (converted) of Gene_expression (expression) of ANG in liver associated with cancer, colon cancer and metastasis
10) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.81 Pain Relevance 0
These results also imply that much of the ANG II available to drive growth of CRC liver metastases is derived from local host production of angiotensinogen, which is then converted to ANG II via high ACE expression in tumors.
Positive_regulation (high) of Gene_expression (expression) of ANG in liver associated with cancer, colon cancer and metastasis
11) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.75 Pain Relevance 0
We show a marked up-regulation of ACE during CRC metastases development, which would presumably favor CRC metastases growth by increasing production of ANG II.
Positive_regulation (increasing) of Gene_expression (production) of ANG associated with colon cancer and metastasis
12) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2860361 Disease Relevance 1.40 Pain Relevance 0
Local tissue ischemia, due to endothelial dysfunction, increases the production of proangiogenic substances such as vascular endothelial growth factor (VEGF), angiogenin, VEGF receptor-2 (KDR), paralleled by decrease of the inhibitors of angiogenesis such as Pigment Epithelium Derived Factor (PEDF) result in retinal neovascularization as well as microangiopathy [5,6].
Positive_regulation (increases) of Gene_expression (production) of angiogenin in Epithelium associated with ischemia and retinal neovascularization
13) Confidence 0.17 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 1.82 Pain Relevance 0.21
Of interest, the ability of MSC cultures of secreting high levels of angiogenic cytokines, such as VEGF, IL-8, angiogenin and CCL2, was significantly (p<0.01) enhanced by the concomitant presence of lymphoma cells.
Positive_regulation (enhanced) of Gene_expression (cultures) of angiogenin associated with lymphatic system cancer and cytokine
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886845 Disease Relevance 0.88 Pain Relevance 0.10
Serosal addition of ANG II produced a concentration-dependent (10(-9)-10(-5) M) increase in I(sc).
Positive_regulation (increase) of Gene_expression (produced) of ANG
15) Confidence 0.08 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10762617 Disease Relevance 0 Pain Relevance 0.18
Figure 5 shows that ARA treatment particularly increased expression of monocyte chemotactic protein (MCP)-1 and angiogenin, while EPA treatment increased IL-10, IL-6, macrophage inflammatory protein (MIP)-1?
Positive_regulation (increased) of Gene_expression (expression) of angiogenin in macrophage associated with inflammation
16) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.28 Pain Relevance 0.27
and GRO), while others were higher expressed after ARA (MCP-1, and angiogenin).
Positive_regulation (higher) of Gene_expression (expressed) of angiogenin
17) Confidence 0.06 Published 2007 Journal Lipids Section Body Doc Link PMC2039812 Disease Relevance 0.78 Pain Relevance 0.28

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