INT81331

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 1999
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.09
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADRBK1, OPRK1) cytosol (ADRBK1) signal transduction (ADRBK1)
aging (ADRBK1) signal transducer activity (OPRK1) cytoplasm (ADRBK1)
ADRBK1 (Homo sapiens)
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 2 86.36 High High
antagonist 1 86.00 High High
agonist 5 81.56 Quite High
Kappa opioid receptor 4 75.00 Quite High
Immobilon 3 68.28 Quite High
Opioid 1 53.40 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 91.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While co-expression of the wild type GRK2, beta-arrestin, or dynamin I had no effect on kappa receptor internalization, co-expression of the dominant negative mutants GRK2-K220R, beta-arrestin (319-418), or dynamin I-K44A significantly inhibited receptor internalization.
GRK2 Neg (no) Regulation (effect) of kappa receptor
1) Confidence 0.03 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10207034 Disease Relevance 0.09 Pain Relevance 0.48

General Comments

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