INT81347

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.10
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Anatomy Link Frequency
follicle 1
uterine 1
olfactory 1
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 42 99.84 Very High Very High Very High
Morphine 106 99.48 Very High Very High Very High
nMDA receptor 1 99.28 Very High Very High Very High
Catecholamine 2 95.04 Very High Very High Very High
Opioid 12 94.80 High High
Lasting pain 2 87.84 High High
GABAergic 2 87.32 High High
Nerve growth factor 3 81.48 Quite High
antagonist 2 78.72 Quite High
long-term potentiation 30 78.56 Quite High
Disease Link Frequency Relevance Heat
Pain 44 99.84 Very High Very High Very High
Cognitive Disorder 21 99.40 Very High Very High Very High
Anaerobic Bacterial Infections 8 97.80 Very High Very High Very High
Reprotox - General 1 47 86.64 High High
Polycystic Ovary Syndrome 4 85.80 High High
Dizziness 1 80.48 Quite High
Vertigo 1 79.36 Quite High
Diarrhoea 2 78.64 Quite High
Xerostomia 2 68.72 Quite High
Dysmenorrhea 2 66.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus modulation of the enzymes 5-alpha reductase and aromatase has to be considered an important gateway to these functions.
Regulation (modulation) of aromatase
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.26
Another study conducted in healthy, estrogen-treated postmenopausal women treated with testosterone did not reveal any effects of aromatase inhibition on cognition [126].
Regulation (effects) of aromatase associated with cognitive disorder
2) Confidence 0.33 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 0.91 Pain Relevance 0
A stimulation protocol dependent conversion of testosterone to estradiol is indeed conceivable, since it is known that aromatase is differentially affected by activation of NMDA receptors (activated during the tetanus) and kainate and AMPA receptors (under basal conditions) (Hojo et al., 2004; Balthazart et al., 2006).
Regulation (affected) of aromatase associated with nmda receptor and anaerobic bacterial infections
3) Confidence 0.30 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3006668 Disease Relevance 0.30 Pain Relevance 0.36
Because E2 serum concentrations did not increase after left or bilateral perforation of the peritoneum, we suppose that the neural information originating from the peritoneum inhibits the mechanisms regulating aromatase activity within the follicle.
Regulation (regulating) of aromatase in follicle
4) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.29 Pain Relevance 0.16
However, such male-typical features of normal development in female rats do not extend to the regulation of preoptic aromatase activity or to the capacity of females to display olfactory behaviors in response to adult E2 exposure, functions which are sexually dimorphic even in the rat.
Regulation (regulation) of aromatase in olfactory
5) Confidence 0.26 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10207281 Disease Relevance 0 Pain Relevance 0.06
The effects of the aromatase inhibitor fadrozole hydrochloride on fetuses and uteri in late pregnant rats.
Regulation (effects) of aromatase
6) Confidence 0.26 Published 2004 Journal J. Endocrinol. Section Title Doc Link 14765986 Disease Relevance 0.13 Pain Relevance 0.09
This study examines the effects of the aromatase inhibitor, fadrozole hydrochloride (Fad), on fetuses, uterine physical properties and the mRNA expression of the uterine enzymes that are related to collagen metabolism during late pregnancy in rats.
Spec (examines) Regulation (effects) of aromatase in uterine
7) Confidence 0.26 Published 2004 Journal J. Endocrinol. Section Abstract Doc Link 14765986 Disease Relevance 0.12 Pain Relevance 0.06
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats

Background

Regulation (modulation) of Aromatase associated with pain and morphine
8) Confidence 0.17 Published 2010 Journal Mol Pain Section Title Doc Link PMC2978140 Disease Relevance 0.19 Pain Relevance 0.95

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox