INT81352

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.51
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
fibroblasts 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 99.20 Very High Very High Very High
cytokine 3 99.06 Very High Very High Very High
dexamethasone 2 97.32 Very High Very High Very High
Inflammation 4 80.68 Quite High
Analgesic 1 78.72 Quite High
cINOD 1 53.04 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 80.68 Quite High
Cancer 2 75.00 Quite High
Necrosis 2 75.00 Quite High
Pseudomonas Infection 1 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.
Negative_regulation (reduced) of Regulation (effect) of IL-1beta associated with kinase c
1) Confidence 0.41 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.28 Pain Relevance 0.36
When the cells were treated simultaneously with benzydamine and the cytokines IL-1 beta or TNF alpha, the agent benzydamine reduced (P < 0.05) the stimulatory effect of IL-1 beta and TNF alpha respectively, on PGE2 and PGI2 production in human gingival fibroblasts.
Negative_regulation (reduced) of Regulation (effect) of IL-1 beta in fibroblasts associated with cytokine
2) Confidence 0.40 Published 1999 Journal Acta Odontol. Scand. Section Abstract Doc Link 10207535 Disease Relevance 0.23 Pain Relevance 0.21

General Comments

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