INT81368

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Context Info
Confidence 0.34
First Reported 1999
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.09
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
nerve 2
fibroblast 2
spinal cord 1
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 9 100.00 Very High Very High Very High
bDMF 2 99.88 Very High Very High Very High
Spinal cord 6 96.28 Very High Very High Very High
anesthesia 1 83.80 Quite High
Dorsal horn 1 81.76 Quite High
Enkephalin 4 67.44 Quite High
neurotrophin 3 1 66.32 Quite High
Somatostatin 2 66.00 Quite High
Neuropeptide 2 64.24 Quite High
Catecholamine 2 58.80 Quite High
Disease Link Frequency Relevance Heat
Frailty 9 99.48 Very High Very High Very High
Injury 5 94.48 High High
Pressure And Volume Under Development 2 93.40 High High
Death 2 92.88 High High
Disease 8 75.00 Quite High
Neurodegenerative Disease 2 67.36 Quite High
Depression 2 57.20 Quite High
Drug Dependence 2 56.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a combination of BDNF and GDNF (but not with NT-3 or NGF) given either 60 or 90 min after SCI significantly reduced the motor dysfunction and spinal cord pathology at 5 h.
NT-3 Neg (not) Binding (combination) of in spinal cord associated with frailty and spinal cord
1) Confidence 0.34 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 18077567 Disease Relevance 1.14 Pain Relevance 0.40
NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), NT-3 (neurotrophin-3) and NT-4 (neurotrophin-4) also mediate additional higher-order activities, such as learning, memory and behaviour, in addition to their established functions for cell survival.
NT-3 Binding (mediate) of in nerve associated with nerve growth factor
2) Confidence 0.10 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16411893 Disease Relevance 0.47 Pain Relevance 0.11
NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), NT-3 (neurotrophin-3) and NT-4 (neurotrophin-4) also mediate additional higher-order activities, such as learning, memory and behaviour, in addition to their established functions for cell survival.
neurotrophin-3 Binding (mediate) of in nerve associated with nerve growth factor
3) Confidence 0.10 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16411893 Disease Relevance 0.47 Pain Relevance 0.11
The growth factors studied include: nerve growth factor (NGF), neurotrophin-3 (NT-3), brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), basic fibroblast growth factor (bFGF) and transforming growth factor beta-1 (TGF-beta1).
neurotrophin-3 Binding (include) of in fibroblast associated with nerve growth factor and bdmf
4) Confidence 0.06 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10209239 Disease Relevance 0 Pain Relevance 0.31
The growth factors studied include: nerve growth factor (NGF), neurotrophin-3 (NT-3), brain derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), basic fibroblast growth factor (bFGF) and transforming growth factor beta-1 (TGF-beta1).
NT-3 Binding (include) of in fibroblast associated with nerve growth factor and bdmf
5) Confidence 0.06 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10209239 Disease Relevance 0 Pain Relevance 0.31

General Comments

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