INT81377

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Context Info
Confidence 0.71
First Reported 1999
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 8
Total Number 17
Disease Relevance 5.15
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Dpp4) extracellular region (Dpp4) cell adhesion (Dpp4)
Golgi apparatus (Dpp4) endoplasmic reticulum (Dpp4) plasma membrane (Dpp4)
Anatomy Link Frequency
bile ducts 3
hepatocytes 3
T-cell 3
Caco-2 2
mononuclear cells 2
Dpp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 168 100.00 Very High Very High Very High
Angina 7 97.60 Very High Very High Very High
Inflammation 17 93.32 High High
Opioid 15 86.24 High High
Dynorphin 7 75.00 Quite High
Enkephalin 4 75.00 Quite High
cINOD 1 69.64 Quite High
cytokine 7 50.00 Quite Low
Kappa opioid receptor 5 32.64 Quite Low
substance P 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 1 99.44 Very High Very High Very High
Autism 21 99.06 Very High Very High Very High
Injury 91 98.92 Very High Very High Very High
Cv General 3 Under Development 7 97.60 Very High Very High Very High
Myocardial Infarction 2 96.80 Very High Very High Very High
Chronic Fatigue Syndrome 65 95.76 Very High Very High Very High
Atherosclerotic Plaque 1 95.64 Very High Very High Very High
INFLAMMATION 18 93.32 High High
Acute Coronary Syndrome 2 85.76 High High
Toxicity 28 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Children with autism had a significantly lower percentage of cells expressing CD3 and CD26, suggesting that they had lower T-cell numbers than their siblings.
Gene_expression (expressing) of CD26 in T-cell associated with autism
1) Confidence 0.71 Published 2003 Journal Dev Med Child Neurol Section Abstract Doc Link 12578238 Disease Relevance 0.44 Pain Relevance 0.35
The percentage of mononuclear cells expressing DPPIV (as CD26) was determined by flow cytometry.
Gene_expression (expressing) of CD26 in mononuclear cells
2) Confidence 0.71 Published 2003 Journal Dev Med Child Neurol Section Abstract Doc Link 12578238 Disease Relevance 0.46 Pain Relevance 0.36
Confirmation that the 110 kDa bands which were immunoreactive with the ZP and DPP IV antibodies represented the same molecule was obtained from a rat liver extract reciprocally immunodepleted of antigens reactive with these two antibodies.
Gene_expression (represented) of DPP IV in bands
3) Confidence 0.67 Published 2001 Journal Life Sci. Section Abstract Doc Link 11205870 Disease Relevance 0.14 Pain Relevance 0.11
In the DPPIV chimeric rats, bile ducts do not express DPPIV before DAPM administration; however, after repeated DAPM treatment ~20% of the biliary ductules express DPPIV, indicating that they are derived from hepatocytes.
Gene_expression (express) of DPPIV in bile ducts associated with bile
4) Confidence 0.64 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.34 Pain Relevance 0.13
DPPIV is expressed only in the hepatocytes in the chimeric rats before DAPM treatment and therefore provides strong evidence that DPPIV-positive biliary cells are originated from hepatocytes after DAPM treatment.
Gene_expression (expressed) of DPPIV in hepatocytes
5) Confidence 0.64 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.31 Pain Relevance 0.07
Neither the hepatocytes nor the BECs express DPPIV in the recipient DPPIV negative rats.
Gene_expression (express) of DPPIV in hepatocytes
6) Confidence 0.64 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.14 Pain Relevance 0.07
It is possible that the biliary cells derived from hepatocytes will suspend the expression of DPPIV as the restoration process come to an end.
Gene_expression (expression) of DPPIV in hepatocytes
7) Confidence 0.64 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.16 Pain Relevance 0.03
In the DPPIV chimeric rats, bile ducts do not express DPPIV before DAPM administration; however, after repeated DAPM treatment ~20% of the biliary ductules express DPPIV, indicating that they are derived from hepatocytes.
Neg (not) Gene_expression (express) of DPPIV in bile ducts associated with bile
8) Confidence 0.64 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.29 Pain Relevance 0.13
In this study, we determined the activities of four aminopeptidases such as aminopeptidase B (APB), M (APM), N (APN) and dipeptidylpeptidase IV (DPP IV) in Caco-2 cells and compared with those in the rat intestinal mucosae.
Spec (determined) Gene_expression (activities) of DPP IV in Caco-2
9) Confidence 0.60 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.13
In this study, we determined the activities of four aminopeptidases such as aminopeptidase B (APB), M (APM), N (APN) and dipeptidylpeptidase IV (DPP IV) in Caco-2 cells and compared with those in the rat intestinal mucosae.
Spec (determined) Gene_expression (activities) of dipeptidylpeptidase IV in Caco-2
10) Confidence 0.60 Published 1999 Journal Life Sci. Section Abstract Doc Link 10210267 Disease Relevance 0 Pain Relevance 0.13
Appearance of DPPIV-positive bile ducts after repeated administration of DAPM
Gene_expression (bile ducts) of DPPIV-positive in bile ducts associated with bile
11) Confidence 0.55 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.71 Pain Relevance 0.23
In the chimeric rats, after a thorough examination, not a single DPPIV-positive bile duct epithelial cell was observed in total 45 portal triads examined in the sections taken randomly.
Gene_expression (duct epithelial cell) of DPPIV-positive in duct epithelial cell associated with bile
12) Confidence 0.55 Published 2010 Journal Comp Hepatol Section Body Doc Link PMC3014870 Disease Relevance 0.16 Pain Relevance 0.05
The percentage of mononuclear cells expressing DPPIV (as CD26) was determined by flow cytometry.
Gene_expression (expressing) of DPPIV in mononuclear cells
13) Confidence 0.48 Published 2003 Journal Dev Med Child Neurol Section Abstract Doc Link 12578238 Disease Relevance 0.46 Pain Relevance 0.36
In this study we examined surface expression of CD26 and the corresponding enzyme activity of dipeptidyl peptidase IV (DPPIV) on the cells of immature murine T-cell line, R1.1.
Spec (examined) Gene_expression (expression) of DPPIV in T-cell
14) Confidence 0.39 Published 2003 Journal Life Sci. Section Abstract Doc Link 12738031 Disease Relevance 0 Pain Relevance 0.04
Moreover abnormal expression of CD26+ is found in autoimmune diseases [6].
Gene_expression (expression) of CD26 associated with autoimmune disease
15) Confidence 0.17 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.72 Pain Relevance 0
Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction.
Gene_expression (expression) of CD26 in T cell associated with angina and myocardial infarction
16) Confidence 0.10 Published 2003 Journal Atherosclerosis Section Title Doc Link 12732389 Disease Relevance 0.77 Pain Relevance 0.33
MAIN RESULTS: Absolute number of CD3+, CD4+, and CD8+, and expression of HLA-DR and activation marker CD25+, CD26+, and CD69+ decreased more in response to surgery after BAL.
Gene_expression (expression) of CD26
17) Confidence 0.05 Published 2005 Journal J Clin Anesth Section Body Doc Link 16297751 Disease Relevance 0.06 Pain Relevance 0

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