INT81399

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2010
Negated 7
Speculated 3
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 23.53
Pain Relevance 7.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) aging (Vcam1) cell adhesion (Vcam1)
Anatomy Link Frequency
plasma 4
knee 3
endothelial cell 2
bone marrow 1
kidney 1
Vcam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 27 99.84 Very High Very High Very High
cytokine 42 99.80 Very High Very High Very High
Osteoarthritis 16 99.64 Very High Very High Very High
tolerance 5 99.46 Very High Very High Very High
cva 20 99.24 Very High Very High Very High
chemokine 11 99.10 Very High Very High Very High
Angina 40 98.96 Very High Very High Very High
Inflammation 151 98.88 Very High Very High Very High
Chronic pancreatitis 6 98.80 Very High Very High Very High
rheumatoid arthritis 50 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 161 100.00 Very High Very High Very High
Knee Osteoarthritis 12 99.84 Very High Very High Very High
Insulin Resistance 12 99.68 Very High Very High Very High
Impaired Glucose Tolerance 7 99.46 Very High Very High Very High
Increased Venous Pressure Under Development 24 99.32 Very High Very High Very High
Alzheimer's Dementia 1 99.32 Very High Very High Very High
Cv General 3 Under Development 54 99.24 Very High Very High Very High
Disease 34 99.24 Very High Very High Very High
INFLAMMATION 196 98.88 Very High Very High Very High
Hypertension 59 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VCAM-1 is expressed on impaired endothelium and is regulated by various factors such as inflammatory cytokines (29).
Regulation (regulated) of VCAM-1 in endothelium associated with inflammation and cytokine
1) Confidence 0.46 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.35 Pain Relevance 0.64
The aim of this study was to evaluate the effects of different hyaluronic acid (HA) forms on synovial fluid levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) during the treatment of patients with knee osteoarthritis (OA).
Regulation (effects) of VCAM-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
2) Confidence 0.38 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.67 Pain Relevance 0.16
Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis.
Regulation (Effects) of vascular cell adhesion molecule-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
3) Confidence 0.34 Published 2004 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 15487709 Disease Relevance 0.85 Pain Relevance 0.29
The aim of this study was to evaluate the effects of different hyaluronic acid (HA) forms on synovial fluid levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) during the treatment of patients with knee osteoarthritis (OA).
Regulation (effects) of vascular cell adhesion molecule-1 in knee associated with knee osteoarthritis, osteoarthritis and adhesions
4) Confidence 0.34 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.67 Pain Relevance 0.16
On the other hand, the circulating levels of VCAM-1 did not differ between patients with class I unstable AP and patients with stable AP (P = 0.782).
Neg (not) Regulation (differ) of VCAM-1 associated with angina
5) Confidence 0.33 Published 2005 Journal International heart journal Section Abstract Doc Link 16157948 Disease Relevance 1.37 Pain Relevance 1.33
A Mediterranean dietary style influences TNF-alpha and VCAM-1 coronary blood levels in unstable angina patients.
Regulation (influences) of VCAM-1 in blood associated with angina
6) Confidence 0.33 Published 2005 Journal Eur J Nutr Section Title Doc Link 16151968 Disease Relevance 0.29 Pain Relevance 0.14
In patients with UAP but lower risk, the baseline values of sICAM-1 and sVCAM-1, although higher than those of the Groups II and III, were not affected by the treatment, that not includes tirofiban.
Regulation (values) of sVCAM-1
7) Confidence 0.26 Published 2004 Journal Thromb J Section Body Doc Link PMC406420 Disease Relevance 0.65 Pain Relevance 0.37
A significant increase in VCAM-1 levels was demonstrated in both groups of patients and ICAM-1 levels in acute myocardial infarction, but the concentrations of VCAM-1 and ICAM-1 in both groups of patients at admission and ten days later did not differ significantly.
Regulation (concentrations) of VCAM-1
8) Confidence 0.23 Published 2003 Journal Rev Esp Cardiol Section Body Doc Link 12605758 Disease Relevance 0.13 Pain Relevance 0
RESULTS: sICAM-1 and sVCAM-1 values in the sera of patients with chronic pancreatitis and with pancreatic carcinoma were significantly higher (p < 0.01) in comparison with the results obtained in the control group.
Regulation (values) of sVCAM-1 associated with pancreatic cancer and chronic pancreatitis
9) Confidence 0.21 Published 2003 Journal Wiad. Lek. Section Abstract Doc Link 12923961 Disease Relevance 1.38 Pain Relevance 0.49
Changes in the vascular density and, vascular endothelial growth factor, vascular cell adhesion molecule and cytokine levels in the infarcted myocardium after bone marrow cells implantation were examined.


Spec (examined) Regulation (Changes) of vascular cell adhesion molecule in bone marrow associated with adhesions and cytokine
10) Confidence 0.20 Published 2008 Journal J Cardiothorac Surg Section Abstract Doc Link PMC2414821 Disease Relevance 0.45 Pain Relevance 0.19
In contrast, sICAM-1 and sVCAM-1 levels remained unchanged or increased above baseline in Group IB at 72 h (Figure 3).
Neg (unchanged) Regulation (unchanged) of sVCAM-1
11) Confidence 0.19 Published 2004 Journal Thromb J Section Body Doc Link PMC406420 Disease Relevance 0.87 Pain Relevance 0
In contrast, the chemokine RANTES or the adhesion molecules ICAM-1 and VCAM-1 were not transcriptionally regulated in the kidney in response to hypertension or diabetes (table 2).
Neg (not) Regulation (regulated) of VCAM-1 in kidney associated with chemokine, diabetes mellitus, hypertension and adhesions
12) Confidence 0.17 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.14 Pain Relevance 0.09
The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation.
Regulation (role) of VCAM-1 in endothelial cell associated with inflammation and adhesions
13) Confidence 0.15 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17305540 Disease Relevance 0.94 Pain Relevance 0.11
Patient groups had higher values of soluble vascular cellular adhesion molecule-1 compared to the control group (734+/-97 SE pg ml(-1)).
Regulation (values) of vascular cellular adhesion molecule-1
14) Confidence 0.13 Published 1999 Journal Int. J. Cardiol. Section Body Doc Link 10213278 Disease Relevance 0.12 Pain Relevance 0
The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation.
Regulation (role) of vascular endothelial cell adhesion molecule-1 in endothelial cell associated with inflammation and adhesions
15) Confidence 0.13 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17305540 Disease Relevance 0.94 Pain Relevance 0.11
Also for sVCAM-1 exercise did not modify plasma levels of sVCAM-1 in controls but increased it in claudicants from 671+/-45 to 751+/-47 ng/ml (p<0.05).
Neg (not) Regulation (modify) of sVCAM-1 in plasma
16) Confidence 0.12 Published 2001 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 11455059 Disease Relevance 0.71 Pain Relevance 0.15
Among measured parameters, the values of carotid intima-media thickness, coronary external elastic membrane area, plaque area, plaque burden, plaque eccentric index and remodeling index, serum high-sensitivity C-reactive protein, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 were significantly higher in unstable AP than in stable AP (p <0.05 to 0.01).
Regulation (values) of vascular cell adhesion molecule-1 in plaque associated with angina and adhesions
17) Confidence 0.12 Published 2007 Journal Am. J. Cardiol. Section Abstract Doc Link 17950787 Disease Relevance 1.75 Pain Relevance 1.18
, and IL-6) as well as 3 cellular adhesion molecule (ICAM-1, VCAM, and E-selectin) mRNA levels following PBBI (Fig. 2).
Regulation (molecule) of VCAM associated with brain injury and adhesions
18) Confidence 0.12 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1933533 Disease Relevance 1.11 Pain Relevance 0.26
In this study, we investigated the effect of tirofiban on the levels of cell adhesion molecules (soluble intercellular adhesion molecule-1, sICAM-1, and vascular cell adhesion molecule-1, sVCAM-1) in patients with unstable angina pectoris (AP).


Spec (investigated) Regulation (effect) of vascular cell adhesion molecule-1 associated with cva and adhesions
19) Confidence 0.12 Published 2004 Journal Thromb J Section Abstract Doc Link PMC406420 Disease Relevance 0.98 Pain Relevance 0.18
In this study, we investigated the effect of tirofiban on the levels of cell adhesion molecules (soluble intercellular adhesion molecule-1, sICAM-1, and vascular cell adhesion molecule-1, sVCAM-1) in patients with unstable angina pectoris (AP).


Spec (investigated) Regulation (effect) of sVCAM-1 associated with cva and adhesions
20) Confidence 0.12 Published 2004 Journal Thromb J Section Abstract Doc Link PMC406420 Disease Relevance 0.98 Pain Relevance 0.18

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