INT81400

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 12.93
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RARA) signal transduction (RARA) nucleus (RARA)
enzyme binding (RARA) transcription factor binding (RARA) cytoplasm (RARA)
Anatomy Link Frequency
thyroid 1
HeLa 1
ganglion 1
RARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 99.56 Very High Very High Very High
agonist 146 99.28 Very High Very High Very High
Neurotransmitter 1 98.48 Very High Very High Very High
opioid receptor 37 88.64 High High
cva 10 86.48 High High
anesthesia 3 84.08 Quite High
Codeine 53 75.20 Quite High
addiction 4 69.68 Quite High
alcohol 1 56.96 Quite High
neuropeptide release 1 50.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 560 100.00 Very High Very High Very High
Rheumatoid Arthritis 293 99.84 Very High Very High Very High
Ganglion Cysts 2 99.84 Very High Very High Very High
Neuroblastoma 94 96.40 Very High Very High Very High
Toxicity 10 93.04 High High
Disease 32 92.76 High High
Carcinoma 81 91.92 High High
Renal Cancer 55 91.28 High High
Apoptosis 121 90.80 High High
Myocardial Infarction 15 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rar-c is also used to account for the effect of CO2 on the cerebral circulation.
Rar Binding (account) of
1) Confidence 0.36 Published 1999 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 10213432 Disease Relevance 0.52 Pain Relevance 0.43
RA, while RAR binds both 9-cis RA and all-trans RA (ATRA).
RAR Binding (binds) of associated with rheumatoid arthritis
2) Confidence 0.26 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.82 Pain Relevance 0
To analyze whether DREAM could also influence RARE-dependent transcription, HeLa cells were transfected with reporter plasmids containing different fragments of the RAR?
RAR Binding (fragments) of in HeLa
3) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.21 Pain Relevance 0
53 (Figure 3A), which binds RXR/RAR heterodimers (26).
RAR Binding (binds) of
4) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.23 Pain Relevance 0
Our results indicate that genes, such as RAR?
RAR Binding (indicate) of
5) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
In addition, RA stimulated the activity of the RAR?
RAR Binding (activity) of associated with rheumatoid arthritis
6) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.63 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
RAR Binding (heterodimer) of associated with rheumatoid arthritis
7) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
This suggests that the requirements for DREAM and RXR/RAR heterodimer binding to these sequences are different and that whereas both hemisites of the response element are required for stimulation by RA, only one hemisite is sufficient for stimulation by DREAM.
RAR Binding (binding) of associated with rheumatoid arthritis
8) Confidence 0.21 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.45 Pain Relevance 0
The active forms of vitamin A, 9-cis RA and all-trans retinoic acid (atRA), also exhibit anti-tumoral properties in many tissues mainly through RXR and retinoic acid-activated receptor (RAR) binding.
retinoic acid-activated receptor Binding (binding) of associated with rheumatoid arthritis
9) Confidence 0.21 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.71 Pain Relevance 0
The active forms of vitamin A, 9-cis RA and all-trans retinoic acid (atRA), also exhibit anti-tumoral properties in many tissues mainly through RXR and retinoic acid-activated receptor (RAR) binding.
RAR Binding (binding) of associated with rheumatoid arthritis
10) Confidence 0.21 Published 2007 Journal Nutr J Section Body Doc Link PMC2018695 Disease Relevance 0.65 Pain Relevance 0
This particular arrangement permits RAR and VDR upon ligand binding to undergo conformational changes that facilitate the recruitment of coactivator complexes.
RAR Binding (binding) of
11) Confidence 0.20 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
RAR Binding (bound) of
12) Confidence 0.20 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
ligand-dependent transcription factors that bind to the retinoic acid receptor
retinoic acid receptor Binding (bind) of
13) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.73 Pain Relevance 0
for both RXR and RAR [34, 35], can restore the function of RXR?
RAR Binding ([34) of
14) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.55 Pain Relevance 0.05
for both RXR and RAR [34, 35], can restore the function of RXR?
RAR Binding (restore) of
15) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.55 Pain Relevance 0.05
This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interactions with TFIIB.
RAR Binding (associates) of in thyroid
16) Confidence 0.19 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.24 Pain Relevance 0.03
(248 bp), and for the RAR?
RAR Binding (for) of
17) Confidence 0.19 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0.06 Pain Relevance 0
abolishes its ability to form heterodimers with RAR?
RAR Binding (form) of
18) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.69 Pain Relevance 0
RA acts on tumor growth by binding and regulating the tumor cell heterodimeric receptors RAR and RXR.
RAR Binding (binding) of associated with cancer and rheumatoid arthritis
19) Confidence 0.12 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.31 Pain Relevance 0.03
For instance, although the RXR-RAR heterodimer binds to both DR1 and DR5, the RXR monomer occupies the 3?
RAR Binding (binds) of
20) Confidence 0.11 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

General Comments

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