INT81403

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
lung 3
spleen 1
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 99.98 Very High Very High Very High
tolerance 9 99.72 Very High Very High Very High
cva 12 99.04 Very High Very High Very High
antagonist 1 98.64 Very High Very High Very High
Calcitonin gene-related peptide 7 93.28 High High
cytokine 15 92.72 High High
Inflammation 8 90.24 High High
opiate 4 88.88 High High
Antinociceptive 1 83.56 Quite High
Spinal cord 1 80.68 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 12 99.04 Very High Very High Very High
Stress 5 86.00 High High
INFLAMMATION 9 79.28 Quite High
Necrosis 2 64.72 Quite High
Cancer 2 64.36 Quite High
Pain 1 59.76 Quite High
Injury 2 48.60 Quite Low
Disease 1 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 1 5.00 Very Low Very Low Very Low
Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, central chemical sympathectomy attenuated the hemorrhage-induced increase in lung and spleen TNF-alpha, enhanced the IL-6 response in spleen and blunted the rise in circulating beta-endorphin levels.
Positive_regulation (enhanced) of Regulation (response) of IL-6 in lung associated with cva
1) Confidence 0.44 Published 1999 Journal Neuroimmunomodulation Section Abstract Doc Link 10213918 Disease Relevance 0.59 Pain Relevance 0.55
Blockade of p38 activity also inhibited the development of tolerance and morphine-induced IL-6 up-regulation.
Positive_regulation (induced) of Regulation (regulation) of IL-6 associated with tolerance and morphine
2) Confidence 0.25 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.06 Pain Relevance 1.75
However, central chemical sympathectomy attenuated the hemorrhage-induced increase in lung and spleen TNF-alpha, enhanced the IL-6 response in spleen and blunted the rise in circulating beta-endorphin levels.
Positive_regulation (enhanced) of in spleen Regulation (response) of IL-6 in lung associated with cva
3) Confidence 0.15 Published 1999 Journal Neuroimmunomodulation Section Abstract Doc Link 10213918 Disease Relevance 0.59 Pain Relevance 0.55
Whereas under BIA, the concentrations of IL-6 were found to be significantly elevated during the course of the study, the release of the soluble IL-2R alpha and the production of IL-1RA were reduced in this patient group in comparison to the TIVA group.
Positive_regulation (elevated) of Regulation (concentrations) of IL-6
4) Confidence 0.03 Published 2001 Journal Anaesthesiol Reanim Section Abstract Doc Link 11256129 Disease Relevance 0.56 Pain Relevance 0.52

General Comments

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