INT81411

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.00
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele) molecular_function (Sele)
cellular_component (Sele)
Anatomy Link Frequency
plasma 1
leukocyte 1
plaque 1
neutrophil 1
Sele (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 2 99.96 Very High Very High Very High
rheumatoid arthritis 48 98.48 Very High Very High Very High
Angina 21 98.40 Very High Very High Very High
ischemia 91 94.72 High High
Inflammation 25 92.64 High High
Osteoarthritis 1 87.68 High High
Inflammatory response 3 83.68 Quite High
Dismenorea 1 83.00 Quite High
anesthesia 5 78.52 Quite High
cytokine 11 72.64 Quite High
Disease Link Frequency Relevance Heat
Adhesions 36 100.00 Very High Very High Very High
Systemic Sclerosis 1 99.24 Very High Very High Very High
Overdose 1 99.04 Very High Very High Very High
Apoptosis 1 98.50 Very High Very High Very High
Rheumatoid Arthritis 50 98.48 Very High Very High Very High
Stable Angina Pectoris 10 98.40 Very High Very High Very High
Cv General 3 Under Development 12 97.52 Very High Very High Very High
Acute Coronary Syndrome 4 96.24 Very High Very High Very High
Myocardial Infarction 12 96.12 Very High Very High Very High
INFLAMMATION 32 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.
Negative_regulation (reversed) of E-selectin associated with antagonist and overdose
1) Confidence 0.38 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.84 Pain Relevance 0.19
NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [22,24].
Negative_regulation (decreasing) of E-selectin in leukocyte associated with adhesions
2) Confidence 0.14 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 1.05 Pain Relevance 0.34
We documented persistent elevation in the levels of soluble ICAM-1 and soluble VCAM-1 and a decrease in the levels of soluble E-selectin in the first 72 hours of acute presentation in patients with unstable angina and subendocardial myocardial infarction.
Negative_regulation (decrease) of E-selectin associated with angina and myocardial infarction
3) Confidence 0.13 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10215296 Disease Relevance 0.61 Pain Relevance 0.22
In conclusion, determination of serum VCAM-1, E-selectin and P-selectin levels seems more useful for detecting coronary plaque destabilization.
Negative_regulation (determination) of E-selectin in plaque
4) Confidence 0.04 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 1.37 Pain Relevance 0.92
RESULTS: Following 12 months' treatment, serum levels of interleukin 6 (IL-6), soluble IL-2 receptor, C-reactive protein, soluble E-selectin, and soluble intercellular adhesion molecule-1 were significantly lower in patients receiving abatacept 10 mg/kg versus placebo.
Negative_regulation (levels) of E-selectin
5) Confidence 0.02 Published 2006 Journal J. Rheumatol. Section Body Doc Link 17014006 Disease Relevance 0.10 Pain Relevance 0
In addition, neutrophil apoptosis was increased and the levels of circulating adhesion molecules ICAM-1 and ELAM-1 were decreased.
Negative_regulation (decreased) of ELAM-1 in neutrophil associated with apoptosis and adhesions
6) Confidence 0.02 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2927584 Disease Relevance 0.87 Pain Relevance 0.18
In a pilot study of a select group of patients with systemic sclerosis, aminaphtone was associated with the downregulation of sELAM-1 and sVCAM-1 concentrations [10].
Negative_regulation (downregulation) of sELAM-1 associated with systemic sclerosis
7) Confidence 0.01 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2905767 Disease Relevance 0.59 Pain Relevance 0.10
In this study, KBG did not decrease the plasma levels of sE-selectin and sICAM-1, but it reduced sVCAM-1, one of the markers of vascular endothelial activation.
Neg (not) Negative_regulation (decrease) of sE-selectin in plasma
8) Confidence 0.01 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513153 Disease Relevance 1.57 Pain Relevance 0.75

General Comments

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