INT81415

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.49
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gabrp)
Anatomy Link Frequency
neurons 1
Gabrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 2 100.00 Very High Very High Very High
Central grey 9 99.74 Very High Very High Very High
Spinal cord 3 99.48 Very High Very High Very High
Analgesic 1 99.08 Very High Very High Very High
Dorsal horn 2 99.00 Very High Very High Very High
pregabalin 4 97.72 Very High Very High Very High
Neurotransmitter 6 97.20 Very High Very High Very High
Gabapentin 3 96.12 Very High Very High Very High
gABA 3 92.88 High High
Dorsal horn neuron 3 92.36 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 9 99.74 Very High Very High Very High
Anxiety Disorder 1 98.64 Very High Very High Very High
Nociception 2 93.36 High High
Convulsion 1 89.68 High High
Epilepsy 2 89.16 High High
Hyperalgesia 1 88.64 High High
Endometriosis (extended) 1 85.68 High High
Reprotox - General 1 1 84.08 Quite High
Depressive Disorder 1 80.24 Quite High
Cancer 1 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also inactivates 3alpha,5alpha-tetrahydroprogesterone, an allosteric modulator of the gamma-aminobutyric acid receptor that has anaesthetic, analgesic, anxiolytic and anti-convulsant effects.
Gene_expression (modulator) of gamma-aminobutyric acid receptor associated with analgesic and anxiety disorder
1) Confidence 0.30 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18765269 Disease Relevance 0.50 Pain Relevance 0.18
Upregulation of gamma-aminobutyric acid transporter expression: role of alkylated gamma-aminobutyric acid derivatives.
Gene_expression (expression) of gamma-aminobutyric acid transporter
2) Confidence 0.21 Published 2001 Journal Biochem. Soc. Trans. Section Title Doc Link 11709066 Disease Relevance 0.27 Pain Relevance 0.69
The present study was designed to determine whether PAG stimulation produces the release of serotonin (5-HT), norepinephrine (NE), Gly, and gamma-aminobutyric acid in the spinal cord dorsal horn and whether the release of these neurotransmitters by PAG stimulation is associated with a long-lasting inhibition of the evoked nociceptive responses of dorsal horn neurons.
Spec (whether) Gene_expression (produces) of gamma-aminobutyric in neurons associated with nociception, neurotransmitter, dorsal horn, dorsal horn neuron, serotonin, central grey and spinal cord
3) Confidence 0.01 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.73 Pain Relevance 0.97

General Comments

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