INT81419

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Context Info
Confidence 0.64
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 11.10
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PAG1) plasma membrane (PAG1) intracellular (PAG1)
Anatomy Link Frequency
output neurons 2
hypothalamus 1
neurons 1
nucleus 1
thalamus 1
PAG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central grey 478 100.00 Very High Very High Very High
Rostral ventromedial medulla 204 100.00 Very High Very High Very High
Periaqueductal grey 43 100.00 Very High Very High Very High
Neurotransmitter 10 100.00 Very High Very High Very High
Locus ceruleus 4 99.98 Very High Very High Very High
Dorsal horn 18 99.66 Very High Very High Very High
Thalamus 10 99.50 Very High Very High Very High
Spinal cord 25 99.42 Very High Very High Very High
IPN 16 98.88 Very High Very High Very High
parabrachial 8 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 623 100.00 Very High Very High Very High
Inflammatory Pain 20 98.88 Very High Very High Very High
Stress 107 98.28 Very High Very High Very High
Nociception 13 97.56 Very High Very High Very High
Panic Disorder 132 94.64 High High
Anxiety Disorder 178 92.32 High High
Hyperalgesia 22 92.00 High High
INFLAMMATION 16 90.04 High High
Pain 137 85.00 Quite High
Cold Sores 23 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
hypothalamus, thalamus, and the periaqueductal grey matter (PAG) (for a recent
Localization (grey matter) of PAG in thalamus associated with urological neuroanatomy, thalamus and central grey
1) Confidence 0.64 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.36 Pain Relevance 0.30
ventrolateral PAG of males, but only half as many PAG-RVM output neurons were
Localization (were) of PAG in output neurons associated with central grey and rostral ventromedial medulla
2) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.62 Pain Relevance 1.55
nucleus, and locus coeruleus project more heavily to the PAG in males than
Localization (project) of PAG in locus coeruleus associated with locus ceruleus and central grey
3) Confidence 0.58 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.08 Pain Relevance 1.23
The present study was designed to determine whether PAG stimulation produces the release of serotonin (5-HT), norepinephrine (NE), Gly, and gamma-aminobutyric acid in the spinal cord dorsal horn and whether the release of these neurotransmitters by PAG stimulation is associated with a long-lasting inhibition of the evoked nociceptive responses of dorsal horn neurons.
Localization (release) of PAG in neurons associated with nociception, neurotransmitter, dorsal horn, dorsal horn neuron, serotonin, central grey and spinal cord
4) Confidence 0.57 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.74 Pain Relevance 0.97
The

high density of steroid receptors localized on PAG-RVM output neurons may contribute to our observed sex differences in morphine

Localization (localized) of PAG-RVM in output neurons associated with central grey, morphine and rostral ventromedial medulla
5) Confidence 0.54 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.18 Pain Relevance 1.29
excitability of descending control systems from the PAG may alter the level of
Localization (excitability) of PAG associated with periaqueductal grey
6) Confidence 0.34 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593562 Disease Relevance 1.67 Pain Relevance 1.07
hypothalamus, thalamus, and the periaqueductal grey matter (PAG) (for a recent
Localization (grey matter) of PAG in hypothalamus associated with urological neuroanatomy, thalamus and central grey
7) Confidence 0.22 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2654309 Disease Relevance 1.36 Pain Relevance 0.30
nucleus, and locus coeruleus project more heavily to the PAG in males than
Localization (project) of PAG in nucleus associated with locus ceruleus and central grey
8) Confidence 0.20 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2633449 Disease Relevance 1.08 Pain Relevance 1.23
Rats were PAG delivered with recombinant HSV-I amplicon vector SHPZ, SHZ or NS.
Localization (delivered) of PAG
9) Confidence 0.17 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18599994 Disease Relevance 0.32 Pain Relevance 0
effects of direct PAG manipulation
Localization (manipulation) of PAG associated with central grey
10) Confidence 0.09 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 0.70 Pain Relevance 0.08

General Comments

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