INT81433

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Context Info
Confidence 0.39
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.81
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 13 84.08 Quite High
dorsal root ganglion 44 76.84 Quite High
Dismenorea 1 67.84 Quite High
qutenza 80 60.92 Quite High
Inflammation 8 26.40 Quite Low
antagonist 10 16.64 Low Low
bradykinin 20 5.00 Very Low Very Low Very Low
nociceptor 12 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
algogenic 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 14 98.56 Very High Very High Very High
Proteinuria 1 92.24 High High
Injury 3 89.56 High High
Ganglion Cysts 46 76.84 Quite High
Dysmenorrhea 1 67.84 Quite High
Stress 8 66.00 Quite High
Cardiovascular Disorder Under Development 4 50.00 Quite Low
Hypertrophy 5 28.32 Quite Low
INFLAMMATION 8 26.40 Quite Low
Coronary Heart Disease 3 25.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence for this is that ET-1 effects were completely inhibited by the PKC inhibitor BIM X, and prevented in the PKC phosphorylation site mutant TRPV1-S800A.
Negative_regulation (inhibited) of Positive_regulation (effects) of ET-1
1) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.08 Pain Relevance 0.10
Evidence for this is that ET-1 effects were completely inhibited by the PKC inhibitor BIM X, and prevented in the PKC phosphorylation site mutant TRPV1-S800A.
Negative_regulation (prevented) of Positive_regulation (effects) of ET-1
2) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.08 Pain Relevance 0.10
The removal of extracellular Ca2+ or the addition of nifedipine inhibited (35%) InsP production due to bombesin and ET-1.
Negative_regulation (inhibited) of Positive_regulation (due) of ET-1
3) Confidence 0.32 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215683 Disease Relevance 0.07 Pain Relevance 0.18
Therefore, ARB can't be enough to block the elevated ET-1 in this model (12).
Negative_regulation (block) of Positive_regulation (elevated) of ET-1
4) Confidence 0.13 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.59 Pain Relevance 0

General Comments

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