INT81443

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 28.40
Pain Relevance 6.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
monocyte 2
vessels 2
endothelium 2
T-cell 2
aorta 1
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 678 100.00 Very High Very High Very High
Central nervous system 185 100.00 Very High Very High Very High
Bioavailability 3 99.84 Very High Very High Very High
aspirin 80 99.60 Very High Very High Very High
Multiple sclerosis 95 99.36 Very High Very High Very High
Angina 10 99.28 Very High Very High Very High
chemokine 73 98.86 Very High Very High Very High
cytokine 277 96.28 Very High Very High Very High
imagery 7 96.28 Very High Very High Very High
agonist 56 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 816 100.00 Very High Very High Very High
Adhesions 332 100.00 Very High Very High Very High
Cancer 248 100.00 Very High Very High Very High
Necrosis 42 100.00 Very High Very High Very High
Diabetes Mellitus 72 99.98 Very High Very High Very High
Stroke 165 99.72 Very High Very High Very High
Multiple Sclerosis 348 99.68 Very High Very High Very High
Endotoxemia 21 99.32 Very High Very High Very High
Atherosclerosis 124 99.30 Very High Very High Very High
Cv General 3 Under Development 23 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of soluble P-selectin, ICAM-1 and VCAM-1 are elevated in patients with angina pectoris or peripheral atherosclerotic disease.
Positive_regulation (elevated) of VCAM-1 associated with angina, atherosclerosis and disease
1) Confidence 0.63 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.24 Pain Relevance 0.18
Studies of monocyte adhesion in isolated perfused carotid arteries harvested from atherosclerotic (apoE-/-) mice show a predominant involvement of P-selectin and its ligand P-selectin glycoprotein-1 (PSGL-1) in rolling and of VLA-4 and VCAM-1 in firm adhesion.
Positive_regulation (involvement) of VCAM-1 in monocyte associated with atherosclerosis and adhesions
2) Confidence 0.46 Published 2001 Journal Acta Physiol. Scand. Section Abstract Doc Link 11678724 Disease Relevance 1.41 Pain Relevance 0.16
Previously published in vitro studies have shown that ASA is able to inhibit induction of VCAM-1 in TNF stimulated HUVECs [27].
Positive_regulation (induction) of VCAM-1 associated with aspirin
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.56 Pain Relevance 0.46
Specifically, the presence of significantly increased numbers of CD45+ leukocytes in the CVOs suggested the recruitment of inflammatory cells into the the parenchyma of the CVOs probably mediated via endothelial ICAM-1 and VCAM-1 which were both upregulated on the microvessels within the CVOs.
Positive_regulation (upregulated) of VCAM-1 in parenchyma associated with inflammation
4) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.67 Pain Relevance 0.19
The adhesion molecules ICAM-1 and VCAM-1 were upregulated on the fenestrated capillaries within the CVOs.
Positive_regulation (upregulated) of VCAM-1 associated with adhesions
5) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC1262737 Disease Relevance 0.65 Pain Relevance 0.11
The adhesion molecules, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), both members of the immunoglobulin superfamily, are upregulated on the endothelial cells of cerebral vessels during EAE and actively involved in the recruitment of inflammatory cells across the BBB (summarized in [1]).
Positive_regulation (upregulated) of vascular cell adhesion molecule in vessels associated with multiple sclerosis, inflammation and adhesions
6) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 1.17 Pain Relevance 0.43
The adhesion molecules, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), both members of the immunoglobulin superfamily, are upregulated on the endothelial cells of cerebral vessels during EAE and actively involved in the recruitment of inflammatory cells across the BBB (summarized in [1]).
Positive_regulation (upregulated) of VCAM-1 in vessels associated with multiple sclerosis, inflammation and adhesions
7) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 1.16 Pain Relevance 0.42
The adhesion molecules ICAM-1 and VCAM-1, which are required for leukocyte entry into the CNS, are expressed on the choroid plexus epithelium [6], become upregulated during EAE, and can mediate lymphocyte binding in vitro [7].
Positive_regulation (upregulated) of VCAM-1 in leukocyte associated with multiple sclerosis, central nervous system and adhesions
8) Confidence 0.37 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.32 Pain Relevance 0.19
on VCAM-1 expression
Positive_regulation (on) of VCAM-1
9) Confidence 0.36 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.07 Pain Relevance 0.12
Histopathological examination showed centrilobular hepatic necrosis with leukocyte infiltration and a large number of apoptotic hepatocytes 10 and 24 h after APAP challenge. mRNA expression of intercellular adhesion molecule 1, vascular cell adhesion molecule 1, interleukin (IL) 1alpha, IL-1beta, IL-6, tumor necrosis factor alpha, monocyte chemoattractant protein 1, macrophage inflammatory protein (MIP) 1alpha, MIP-2, KC, IP-10, Mig, Fas, and inducible nitric oxide synthase was enhanced in the liver of wild-type mice injected with APAP.
Positive_regulation (enhanced) of vascular cell adhesion molecule 1 in monocyte associated with necrosis, inflammation, cancer, apoptosis and adhesions
10) Confidence 0.36 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 0.98 Pain Relevance 0.21
The mean levels of mRNA for CD44, VCAM-1, MCP-1, and Cox-2, in fact, were elevated in 6-weeks old apoE?
Positive_regulation (elevated) of VCAM-1
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.51 Pain Relevance 0.04
Inflammatory modulators include intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-selectin, and NF-?
Positive_regulation (include) of VCAM-1 associated with inflammation and adhesions
12) Confidence 0.31 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.94 Pain Relevance 0.12
Inflammatory modulators include intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-selectin, and NF-?
Positive_regulation (include) of vascular adhesion molecule-1 associated with inflammation and adhesions
13) Confidence 0.31 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.94 Pain Relevance 0.12
Low NO bioavailability can up-regulate VCAM-1 in the endothelial cell layer via induction of NF-?
Positive_regulation (regulate) of VCAM-1 in endothelial cell associated with bioavailability
14) Confidence 0.29 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.05 Pain Relevance 0.18
In patients, VCAM-1 was increased up to 5 days after symptom onset while ICAM-2 and PECAM-1 were not increased after injury [123,124].
Positive_regulation (increased) of VCAM-1 associated with injury
15) Confidence 0.28 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 1.08 Pain Relevance 0.06
Adhesion molecules on the BBB, such as ICAM-1 and VCAM-1, play important roles and may enhance T-cell trafficking into the CNS.
Spec (may) Positive_regulation (enhance) of VCAM-1 in T-cell associated with central nervous system and adhesions
16) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.32 Pain Relevance 0.59
Calabresi et al. [33] found increased levels of soluble VCAM-1 in the sera of MS patients, which correlated with a decrease in the number of contrast-enhancing lesions on magnetic resonance imaging during IFN-?
Positive_regulation (increased) of VCAM-1 associated with multiple sclerosis and imagery
17) Confidence 0.25 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.14 Pain Relevance 0.56
Because soluble VCAM-1 results from the cleavage of its bound form, increased serum levels of soluble VCAM-1 might reflect a decrease in VCAM-1 expression on endothelium in MS patients treated with IFN-?.
Positive_regulation (increased) of VCAM-1 in endothelium associated with multiple sclerosis
18) Confidence 0.25 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.37 Pain Relevance 0.61
that induce endothelial vascular cell adhesion molecule 1 (VCAM1) [18].
Positive_regulation (induce) of VCAM1 associated with adhesions
19) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.49 Pain Relevance 0.05
that induce endothelial vascular cell adhesion molecule 1 (VCAM1) [18].
Positive_regulation (induce) of vascular cell adhesion molecule 1 associated with adhesions
20) Confidence 0.24 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.49 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox