INT81444

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 40
Total Number 42
Disease Relevance 46.38
Pain Relevance 8.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
leukocytes 11
extracellular matrix 8
endothelial cells 7
aorta 6
eosinophils 4
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 97 100.00 Very High Very High Very High
Inflammatory mediators 13 100.00 Very High Very High Very High
cytokine 302 99.98 Very High Very High Very High
aspirin 92 99.98 Very High Very High Very High
cocaine 6 99.08 Very High Very High Very High
metalloproteinase 83 98.64 Very High Very High Very High
Inflammation 767 98.08 Very High Very High Very High
Inflammatory response 89 97.16 Very High Very High Very High
ischemia 71 96.88 Very High Very High Very High
Central nervous system 135 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 861 100.00 Very High Very High Very High
Atherosclerosis 328 100.00 Very High Very High Very High
Adhesions 316 100.00 Very High Very High Very High
Disease 224 100.00 Very High Very High Very High
Burns 216 99.98 Very High Very High Very High
Diabetes Mellitus 193 99.98 Very High Very High Very High
Multiple Sclerosis 166 99.96 Very High Very High Very High
Hyperplasia 10 99.00 Very High Very High Very High
Asthma 254 98.98 Very High Very High Very High
Injury 326 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both strains of mice, the number of infiltrated eosinophils increased over time, with VCAM-1 expression on vascular endothelial cells peaking at 9 h after treatment, and decreasing gradually within 24 h after treatment.
Positive_regulation (increased) of Gene_expression (expression) of VCAM-1 in eosinophils
1) Confidence 0.70 Published 2006 Journal Jpn. J. Ophthalmol. Section Body Doc Link 16767373 Disease Relevance 0 Pain Relevance 0
Basal vascular superoxide production and NAD(P)H oxidase activity, vascular cell adhesion molecule-1 expression, and macrophage infiltration were significantly increased only in DOCA-salt +/+ mice.
Positive_regulation (increased) of Gene_expression (expression) of vascular cell adhesion molecule-1 in macrophage associated with adhesions
2) Confidence 0.55 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17142347 Disease Relevance 0.59 Pain Relevance 0.17
IL-4 plays an important role in the production of IgE, but mediates also other pathways such as the differentiation of Th-lymphocytes, the ability to induce the expression of vascular cell adhesion molecule 1 (VCAM-1) and the production of mucus in the asthmatic airway [30].
Positive_regulation (induce) of Gene_expression (expression) of VCAM-1 in lymphocytes associated with asthma and adhesions
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 0.76 Pain Relevance 0.06
Treatment with high dose ASA resulted in a decreased VCAM-1 expression below and at the bifurcation (p?
Positive_regulation (resulted) of Gene_expression (expression) of VCAM-1 associated with aspirin
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943480 Disease Relevance 0.11 Pain Relevance 0.24
Expression of VCAM-1 is induced by lysophosphatidylcholine present in Ox-LDL and by products of lipolysis (Kume et al 1992; Saxena et al 1992).
Positive_regulation (induced) of Gene_expression (Expression) of VCAM-1
5) Confidence 0.43 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.13 Pain Relevance 0.15
The upregulated expression of ICAM-1 and VCAM-1 on the microvessels of the CVOs during EAE suggests that the same molecules mediating immune cell entry across the BBB might be involved in guiding inflammatory cells into the CVOs.
Positive_regulation (upregulated) of Gene_expression (expression) of VCAM-1 in immune cell associated with multiple sclerosis and inflammation
6) Confidence 0.40 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.81 Pain Relevance 0.20
IL-4 plays an important role in the production of IgE, but mediates also other pathways such as the differentiation of Th-lymphocytes, the ability to induce the expression of vascular cell adhesion molecule 1 (VCAM-1) and the production of mucus in the asthmatic airway [30].
Positive_regulation (induce) of Gene_expression (expression) of vascular cell adhesion molecule 1 in lymphocytes associated with asthma and adhesions
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935354 Disease Relevance 0.76 Pain Relevance 0.06
levels are increased during asthma exacerbations, and this change is associated with increased expression of ICAM-1, VCAM-1, and E-selectin.37 In our present study, we found that the expression of VCAM-1 in the lung tissues was significantly decreased in the sTNFR-treatment group compared with the OVA group, suggesting that anti-inflammatory effect of sTNFR may in part be dependent on down-regulation of vascular adhesion molecules and consequent reduction of cell traffic into airway.
Positive_regulation (increased) of Gene_expression (expression) of VCAM-1 in lung associated with asthma, inflammation and adhesions
8) Confidence 0.36 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.11 Pain Relevance 0.23
There was a trend toward increased expression of VCAM-1 and cathepsin-B in aorta lysates of the apoE?
Positive_regulation (rend towa) of Gene_expression (d increase) of VCAM-1 in aorta
9) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.40 Pain Relevance 0.04
As shown in Figs. 3 and 4, an increase in the expression of VCAM-1 was observed during prolonged allergen challenge, while administration of sTNFR considerably decreased the VCAM-1 expression.


Positive_regulation (increase) of Gene_expression (expression) of VCAM-1
10) Confidence 0.33 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 0.34 Pain Relevance 0.23
and IL-1 interact synergistically with IL-4 and IL-13 to augment VCAM-1 expression as well as intercellular adhesion molecule-1 (ICAM-1, CD54) expression.94 Recent data suggest that TNF-?
Positive_regulation (augment) of Gene_expression (expression) of VCAM-1 associated with adhesions
11) Confidence 0.32 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.88 Pain Relevance 0
Recent studies have shown that cytokine-induced expression of VCAM-1, ICAM-1, and E-selectin is inhibited by HDL (Cockerill et al 1995; Ashby et al 1998; Nofer et al 2003; Barter et al 2004).
Positive_regulation (induced) of Gene_expression (expression) of VCAM-1 associated with disorder of lipid metabolism and cytokine
12) Confidence 0.31 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.00 Pain Relevance 0.15
These functions include the upregulation of VCAM1 expression, prolongation of eosinophil survival, eosinophil activation, and as a chemotactic agent.
Positive_regulation (upregulation) of Gene_expression (expression) of VCAM1 in eosinophil
13) Confidence 0.30 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.29 Pain Relevance 0.22
Our previous studies 23, 24 have showed that burn-induced overexpression of adhesion molecules (such as ICAM-1, VCAM-1) on endothelial cells and leukocytes might contribute to liver and lung tissue injury, subsequently leading the multiple organ dysfunction syndrome (MODS).
Positive_regulation (induced) of Gene_expression (overexpression) of VCAM-1 in leukocytes associated with multiple organ failure, burns, injury and adhesions
14) Confidence 0.29 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.21 Pain Relevance 0.20
Our previous studies 23, 24 have showed that burn-induced overexpression of adhesion molecules (such as ICAM-1, VCAM-1) on endothelial cells and leukocytes might contribute to liver and lung tissue injury, subsequently leading the multiple organ dysfunction syndrome (MODS).
Positive_regulation (overexpression) of Gene_expression (overexpression) of VCAM-1 in leukocytes associated with multiple organ failure, burns, injury and adhesions
15) Confidence 0.29 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.20 Pain Relevance 0.20
Our previous studies 23, 24 have showed that burn-induced overexpression of adhesion molecules (such as ICAM-1, VCAM-1) on endothelial cells and leukocytes might contribute to liver and lung tissue injury, subsequently leading the multiple organ dysfunction syndrome (MODS).
Spec (might) Positive_regulation (contribute) of Gene_expression (overexpression) of VCAM-1 in leukocytes associated with multiple organ failure, burns, injury and adhesions
16) Confidence 0.29 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.21 Pain Relevance 0.20
These activated T cells increase the expression of adhesion molecules such as intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 on blood–brain barrier (BBB) endothelial cells.
Positive_regulation (increase) of Gene_expression (expression) of vascular cell adhesion molecule in endothelial cells associated with adhesions
17) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.77 Pain Relevance 0.59
In EAE, expression of ICAM-1 and VCAM-1 correlates with disease phase, specifically upregulation during the initial phase and decreased expression during disease remission [32].
Positive_regulation (upregulation) of Gene_expression (expression) of VCAM-1 associated with multiple sclerosis and disease
18) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC153843 Disease Relevance 1.23 Pain Relevance 0.54
Expression of ICAM-1 and VCAM-1, molecules that are crucial for lymphocyte adhesion and transmigration, were induced on choroid plexus epithelium [6] and other CVO during inflammation [7].
Positive_regulation (induced) of Gene_expression (Expression) of VCAM-1 in choroid plexus epithelium associated with inflammation and adhesions
19) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.95 Pain Relevance 0.57
decreases severity of atherosclerosis through the increased expression of VCAM-1 and MCP-1 [84, 85].


Positive_regulation (increased) of Gene_expression (expression) of VCAM-1 associated with atherosclerosis
20) Confidence 0.21 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2841501 Disease Relevance 1.10 Pain Relevance 0.37

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