INT81458

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.18
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cntf) cytosol (Cntf) extracellular space (Cntf)
growth (Cntf) nucleus (Cntf) cytoplasm (Cntf)
Anatomy Link Frequency
ciliary 4
spinal cord 2
brain 1
lens 1
astrocytes 1
Cntf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 21 100.00 Very High Very High Very High
Neuropeptide 3 99.90 Very High Very High Very High
Spinal cord 261 99.56 Very High Very High Very High
Opioid 3 99.54 Very High Very High Very High
Glutamate 40 99.48 Very High Very High Very High
orphanin 12 98.96 Very High Very High Very High
Pain 28 98.16 Very High Very High Very High
chemokine 12 96.44 Very High Very High Very High
cytokine 40 95.84 Very High Very High Very High
intrathecal 1 89.24 High High
Disease Link Frequency Relevance Heat
Injury 325 100.00 Very High Very High Very High
Spinal Cord Injury 209 99.92 Very High Very High Very High
Schizophrenia 74 98.44 Very High Very High Very High
Pain 23 98.16 Very High Very High Very High
Optic Nerve Injuries 2 97.04 Very High Very High Very High
Syndrome 28 89.36 High High
Cicatrix 25 89.28 High High
Recurrence 8 88.52 High High
Middle Cerebral Artery Infarction 49 87.20 High High
Leukemia 4 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CNTF is also an injury-induced factor in the brain playing a crucial role in astrogliosis.
Positive_regulation (injury-induced) of CNTF in brain associated with injury
1) Confidence 0.47 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10217264 Disease Relevance 0.10 Pain Relevance 0.37
We have identified the gene encoding nociceptin/orphanin FQ (N/OFQ), the novel opioid-like neuropeptide, as responsive to ciliary neurotrophic factor (CNTF).
Positive_regulation (responsive) of CNTF in ciliary associated with orphanin, neuropeptide and opioid
2) Confidence 0.47 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10217264 Disease Relevance 0.07 Pain Relevance 0.40
In contrast, GRPs grown in the presence of the gp130 receptor agonist CNTF generate GFAP+ astrocytes (GDAsCNTF) with processes that are labeled by A2B5 [17].
Positive_regulation (presence) of CNTF in astrocytes associated with agonist
3) Confidence 0.46 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.55 Pain Relevance 0.40
We tested the hypothesis that an increased function of glial glutamate transporters (GTs) could underlie CNTF-mediated neuroprotection.
Positive_regulation (underlie) of CNTF associated with glutamate
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.18
We have identified the gene encoding nociceptin/orphanin FQ (N/OFQ), the novel opioid-like neuropeptide, as responsive to ciliary neurotrophic factor (CNTF).
Positive_regulation (responsive) of ciliary neurotrophic factor in ciliary associated with orphanin, neuropeptide and opioid
5) Confidence 0.41 Published 1999 Journal J. Neurochem. Section Abstract Doc Link 10217264 Disease Relevance 0.07 Pain Relevance 0.40
The presence of the null FS63TER allele of the rs18000169 polymorphism in the gene encoding the ciliary neurotropic factor (CNTF) may potentially increase the risk of schizophrenia.
Positive_regulation (ciliary) of CNTF in ciliary associated with schizophrenia
6) Confidence 0.38 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.52 Pain Relevance 0.04
The presence of the null FS63TER allele of the rs18000169 polymorphism in the gene encoding the ciliary neurotropic factor (CNTF) may potentially increase the risk of schizophrenia.
Positive_regulation (ciliary) of neurotropic factor in ciliary associated with schizophrenia
7) Confidence 0.34 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.52 Pain Relevance 0.04
Recently, it is also reported that elevation of both FGF2 and CNTF level after spinal cord injury induces development of oligodendrocytes [54].
Positive_regulation (elevation) of CNTF in spinal cord associated with spinal cord
8) Confidence 0.28 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.19 Pain Relevance 0.15
It is interesting to note that several neurotrophic factors such as GDNF, BDNF, BMP-7, CNTF and VEGF were upregulated in the transplanted HMO6 human microglial cells as compared to HMO6 cells in culture.
Positive_regulation (upregulated) of CNTF in microglial cells
9) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909196 Disease Relevance 0.37 Pain Relevance 0.37
CNTF, LIF and IL-6 are known to be upregulated at sites of spinal cord injury [60-65] and it is possible that some or all of these factors may also drive the differentiation of local endogenous glial precursors to a GDACNTF-like phenotype (Olig2+/GFAP+) that contributes to the formation of axon-growth-inhibitory scar tissue.
Positive_regulation (upregulated) of CNTF in spinal cord associated with cicatrix and spinal cord
10) Confidence 0.19 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.11 Pain Relevance 0.61
Recently, it was demonstrated that LIF and CNTF are important growth factors caused by lens damage that protect RGCs and stimulate axonal regeneration after optic nerve injury [71].
Positive_regulation (caused) of CNTF in lens associated with optic nerve injuries
11) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.66 Pain Relevance 0.21

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