INT8146

Context Info Confidence 0.14 First Reported 1992 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 7 Disease Relevance 0.89 Pain Relevance 0.75

peptidase activity (PSENEN) Golgi apparatus (PSENEN) endoplasmic reticulum (PSENEN) plasma membrane (PSENEN)

PSENEN (Homo sapiens)

Pain Link Frequency Relevance Heat opioid receptor 4 100.00 Dynorphin 1 100.00 Enkephalin 2 99.68 Opioid 6 96.32 Potency 2 89.68 antagonist 2 80.48 cocaine 1 65.20 Nicotine 1 64.48 cINOD 12 41.52 imagery 60 5.00

Disease Link Frequency Relevance Heat Disease 60 92.00 Alzheimer's Dementia 66 89.44 Toxicity 6 82.96 INFLAMMATION 6 41.28 Targeted Disruption 6 40.56 Death 6 10.32 Infection 18 5.00 Aging 6 5.00 Viral Infection 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These peptides were prototypic for opioid receptors of the following types: kappa [dynorphin(1-13)], mu (DAMGO) H-Tyr-D-Ala2-Gly-N-Me-Phe-Gly5- ol, and delta (DPDPE) H-Tyr-O-Pen-Gly-Phe-D-Pen-OH[D-Pen2,D-Pen5]enkephalin.

Gene_expression (prototypic) of D-Pen2 associated with dynorphin, enkephalin and opioid receptor

1) Confidence 0.14 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.75

-secretase components (Pen2, Aph1 and PS1) or pharmacological targeting of APP (fenofibrate) lead to a common conformational change of PS1: closer proximity of the PS1 NT and TM6-7 loop.

Gene_expression (proximity) of Pen2

2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0

-secretase complex components, Pen2, leads to an increase in the A?

Gene_expression (components) of Pen2

3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.36 Pain Relevance 0

These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?

Gene_expression (itself) of Pen2

4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0

We found a statistically significant shortening of the donor lifetime per cell in the flag-Pen2 transfected cells in both PS1 NT-CT and PS1 NT-loop assays (Table 3).

Gene_expression (transfected) of Pen2

5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0

Correspondingly, when we monitored G-PS1-R conformation in living cells by the FLIM assay we found that cells co-transfected with flag-Pen2 displayed closer PS1 NT-loop proximity compared to that in the wt Pen2 transfected cells, as reflected by the shortening of the average donor fluorophore lifetime in flag-Pen2 expressing cells (Table 3).

Gene_expression (expressing) of Pen2

6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.14 Pain Relevance 0

We found that in the conditioned media of the flag-Pen2 transfected cells the A?

Gene_expression (transfected) of Pen2

7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.23 Pain Relevance 0

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