INT8146

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Context Info
Confidence 0.14
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 0.89
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PSENEN) Golgi apparatus (PSENEN) endoplasmic reticulum (PSENEN)
plasma membrane (PSENEN)
PSENEN (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 4 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Enkephalin 2 99.68 Very High Very High Very High
Opioid 6 96.32 Very High Very High Very High
Potency 2 89.68 High High
antagonist 2 80.48 Quite High
cocaine 1 65.20 Quite High
Nicotine 1 64.48 Quite High
cINOD 12 41.52 Quite Low
imagery 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 60 92.00 High High
Alzheimer's Dementia 66 89.44 High High
Toxicity 6 82.96 Quite High
INFLAMMATION 6 41.28 Quite Low
Targeted Disruption 6 40.56 Quite Low
Death 6 10.32 Low Low
Infection 18 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Viral Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These peptides were prototypic for opioid receptors of the following types: kappa [dynorphin(1-13)], mu (DAMGO) H-Tyr-D-Ala2-Gly-N-Me-Phe-Gly5- ol, and delta (DPDPE) H-Tyr-O-Pen-Gly-Phe-D-Pen-OH[D-Pen2,D-Pen5]enkephalin.
Gene_expression (prototypic) of D-Pen2 associated with dynorphin, enkephalin and opioid receptor
1) Confidence 0.14 Published 1992 Journal Peptides Section Abstract Doc Link 1362265 Disease Relevance 0 Pain Relevance 0.75
-secretase components (Pen2, Aph1 and PS1) or pharmacological targeting of APP (fenofibrate) lead to a common conformational change of PS1: closer proximity of the PS1 NT and TM6-7 loop.
Gene_expression (proximity) of Pen2
2) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
-secretase complex components, Pen2, leads to an increase in the A?
Gene_expression (components) of Pen2
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.36 Pain Relevance 0
These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?
Gene_expression (itself) of Pen2
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0
We found a statistically significant shortening of the donor lifetime per cell in the flag-Pen2 transfected cells in both PS1 NT-CT and PS1 NT-loop assays (Table 3).
Gene_expression (transfected) of Pen2
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
Correspondingly, when we monitored G-PS1-R conformation in living cells by the FLIM assay we found that cells co-transfected with flag-Pen2 displayed closer PS1 NT-loop proximity compared to that in the wt Pen2 transfected cells, as reflected by the shortening of the average donor fluorophore lifetime in flag-Pen2 expressing cells (Table 3).
Gene_expression (expressing) of Pen2
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.14 Pain Relevance 0
We found that in the conditioned media of the flag-Pen2 transfected cells the A?
Gene_expression (transfected) of Pen2
7) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.23 Pain Relevance 0

General Comments

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