INT81485

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 8.30
Pain Relevance 4.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN) extracellular region (IL1RN) plasma membrane (IL1RN)
nucleus (IL1RN) intracellular (IL1RN) cytoplasm (IL1RN)
Anatomy Link Frequency
synovial fluid 1
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 71 100.00 Very High Very High Very High
Dismenorea 4 100.00 Very High Very High Very High
cytokine 119 99.98 Very High Very High Very High
metalloproteinase 30 99.84 Very High Very High Very High
endometriosis 2 99.28 Very High Very High Very High
Angina 12 98.04 Very High Very High Very High
Inflammation 181 96.80 Very High Very High Very High
Inflammatory marker 10 96.56 Very High Very High Very High
Myofascial pain syndrome 5 96.00 Very High Very High Very High
ischemia 4 94.88 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Disorders 15 99.64 Very High Very High Very High
Systemic Lupus Erythematosus 7 99.44 Very High Very High Very High
Disease 73 99.36 Very High Very High Very High
Endometriosis (extended) 2 99.28 Very High Very High Very High
Cv General 3 Under Development 10 98.04 Very High Very High Very High
Reprotox - General 1 2 97.92 Very High Very High Very High
Injury 17 97.32 Very High Very High Very High
INFLAMMATION 200 96.80 Very High Very High Very High
Premature Birth 53 94.88 High High
Cv Unclassified Under Development 2 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
concentration and a diminished IL-1ra:IL-1?
Negative_regulation (diminished) of IL-1ra
1) Confidence 0.57 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892066 Disease Relevance 0.55 Pain Relevance 0.19
Immunity in physical exercise is likely regulated by subtle tuning of cytokine levels; for example, a partial reduction in IL-1ra could reinforce immune defenses against exercise-associated micro-injuries.
Negative_regulation (reduction) of IL-1ra associated with injury and cytokine
2) Confidence 0.43 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.45 Pain Relevance 0.21
However, contrasting findings were obtained for the association of IL-1RN*2 with IL-1ra levels; some authors found that the IL-1RN*2 allele is associated with reduced IL-1ra [14,57,58], but other authors observed no association [29] or even increased IL-1ra [16,18,21].
Negative_regulation (reduced) of IL-1ra
3) Confidence 0.43 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.34 Pain Relevance 0.08
In the current study we have examined the evidence for the existence of this mechanism in intact human IVD tissue and the potential for MDP inhibitors and IL-1Ra to reverse the disease process.
Negative_regulation (inhibitors) of IL-1Ra associated with disease
4) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.28 Pain Relevance 0.09
Demonstrating that inhibitors of IL-1Ra almost completely eliminate matrix degrading activity places IL-1 as a key regulator of matrix degradation in DIVD.
Negative_regulation (inhibitors) of IL-1Ra
5) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.21 Pain Relevance 0.16
, IL-1Ra and enzyme inhibitors).
Negative_regulation (inhibitors) of IL-1Ra
6) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.11
A single, daily, subcutaneous 100 mg injection of IL-1ra is the standard dose of IL-1ra for all individuals with normal renal function.
Negative_regulation (injection) of IL-1ra
7) Confidence 0.36 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.75 Pain Relevance 0.44
We hypothesized that, in SLE, there might be a relative deficiency in the physiologic antagonist of IL-1, IL-1 receptor antagonist (IL-1RA).
Negative_regulation (deficiency) of antagonist associated with antagonist and systemic lupus erythematosus
8) Confidence 0.36 Published 2004 Journal Lupus Section Abstract Doc Link 15462491 Disease Relevance 0.87 Pain Relevance 0.27
The possibility of limiting and controlling the delivery of a cytokine inhibitor of high and selective activity such as IL-1ra may offer enormous advantages in terms of efficacy and safety in the treatment of certain inflammatory disorders, where the pathogenic role of IL-1 is demonstrated.
Negative_regulation (inhibitor) of IL-1ra associated with inflammation and cytokine
9) Confidence 0.31 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.21 Pain Relevance 0.12
Serial dilutions of either S. gordonii GP1300 culture supernatant (containing 0.1 mg/litre of RVFP/IL-1ra) or purified E. coli RVFP/IL-1ra were tested for their capacity to inhibit IL-1?
Negative_regulation (litre) of IL-1ra
10) Confidence 0.30 Published 2003 Journal BMC Biotechnol Section Body Doc Link PMC222906 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: The results suggest that deficiencies of IL-1ra, IL-10, and TGF-beta1 probably play an important role in the cause and pathogenesis of TMJ ID and OA.


Spec (probably) Negative_regulation (deficiencies) of IL-1ra
11) Confidence 0.15 Published 1999 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 10437719 Disease Relevance 0.06 Pain Relevance 0
In addition to increased IL-1 beta, development of TMD may also lead to decreased IL-1ra and increased sIL-1RII in response to increasing IL-1.
Negative_regulation (decreased) of IL-1ra associated with temporomandibular joint disorders
12) Confidence 0.13 Published 2004 Journal Arch. Oral Biol. Section Abstract Doc Link 15099807 Disease Relevance 1.06 Pain Relevance 0.43
Determination of interleukin-1 receptor antagonist, interleukin-10, and transforming growth factor-beta1 in synovial fluid aspirates of patients with temporomandibular disorders.
Negative_regulation (Determination) of interleukin-1 receptor antagonist in synovial fluid associated with antagonist and myofascial pain syndrome
13) Confidence 0.11 Published 1999 Journal J. Oral Maxillofac. Surg. Section Title Doc Link 10437719 Disease Relevance 0.10 Pain Relevance 0.28
Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and disease-related dysmenorrhea.
Negative_regulation (Decreased) of interleukin-1 receptor antagonist associated with endometriosis, antagonist, dismenorea and disease
14) Confidence 0.10 Published 2007 Journal Fertil. Steril. Section Title Doc Link 17292896 Disease Relevance 0.30 Pain Relevance 0.39
Six-month reduction in both IL-1Ra and CRP levels was significant in patients with unstable angina (n = 18; IL-1Ra: from 175 to 119 pg/ml, P = 0.001; CRP: from 0.52 to 0.18 mg/dl, P = 0.002) and nonsignificant in those with stable angina (n = 13) on admission (IL-1Ra: from 123 to 158 pg/ml, P = 0.22; CRP: from 0.19 to 0.10 mg/dl, P = 0.44).
Negative_regulation (reduction) of IL-1Ra associated with angina
15) Confidence 0.09 Published 2002 Journal Catheter Cardiovasc Interv Section Abstract Doc Link 12112886 Disease Relevance 0.63 Pain Relevance 0.46
In conclusion, a significant reduction of IL-1Ra and CRP levels is observed 6 months after stent implantation in patients with preprocedural unstable angina who remain free of ischemia.
Negative_regulation (reduction) of IL-1Ra associated with angina and ischemia
16) Confidence 0.09 Published 2002 Journal Catheter Cardiovasc Interv Section Abstract Doc Link 12112886 Disease Relevance 0.59 Pain Relevance 0.47
In group 1, mean IL-1Ra decreased at 48 hours by 12%, and IL-6 diminished at 48 hours by 13%.
Negative_regulation (decreased) of IL-1Ra
17) Confidence 0.08 Published 1999 Journal Circulation Section Body Doc Link 10217645 Disease Relevance 0.20 Pain Relevance 0
In a follow-up study, interleukin-1 receptor antagonist (IL-1RA), was validated and shown to decrease in concentration during the course of the pregnancy.
Negative_regulation (decrease) of antagonist associated with antagonist
18) Confidence 0.07 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.24 Pain Relevance 0.13
IL-1Ra, TNFsR, tissue inhibitor of metalloproteinases-1) controls the process of tissue destruction [3,14,15].
Negative_regulation (inhibitor) of IL-1Ra associated with metalloproteinase
19) Confidence 0.01 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.77 Pain Relevance 0.51
Prognostic value of interleukin-1 receptor antagonist in patients undergoing percutaneous coronary intervention.
Negative_regulation (value) of antagonist associated with antagonist
20) Confidence 0.00 Published 2002 Journal Am. J. Cardiol. Section Title Doc Link 11835913 Disease Relevance 0.62 Pain Relevance 0.34

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox